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The 'Immunogenetics of Aging' project is a component introduced in the 14th International HLA and Immunogenetics Workshop (IHIW) and developed further within subsequent workshops. The aim was to determine the relevance of immunogenetic markers, focusing on HLA, cytokine genes, and some innate immunity genes, for successful aging and an increased capacity to reach the extreme limits of life-span. Within the 17th IHIW we applied Next Generation Sequencing methods to refine further HLA associations at allele level in longevity, and to extend our knowledge to additional loci such as HLA-DQA1, HLA-DPB1 and HLA-DPA1. Analysis of relatively small number of healthy elderly and young controls from four populations showed that some HLA class I and class II alleles were significantly positively associated with healthy aging. Additionally we observed statistically significant differences in HLA allele distribution when the analysis was performed separately in elderly females and males compared to sex-matched young controls. Haplotypes, probably associated with better control of viral and malignant diseases were increased in the elderly sample. These preliminary NGS data could confirm our hypotheses that survival and longevity might be associated with selection of HLA alleles and haplotypes conferring disease resistance or susceptibility. Therefore HLA alleles and haplotypes could be informative immunogenetic markers for successful ageing.

Titel:	17th IHIW component "Immunogenetics of Ageing" - New NGS data.
Autor/in / Beteiligte Person:	Ivanova, M ; Creary, LE ; Al Hadra, B ; Lukanov, T ; Mazzocco, M ; Sacchi, N ; Ameen, R ; Al-Shemmari, S ; Moise, A ; Ursu, LD ; Constantinescu, I ; Vayntrub, T ; Fernández-Viňa, MA ; Shivarov, V ; Naumova, E
Zeitschrift:	Human immunology, Jg. 80 (2019-09-01), Heft 9, S. 703-713
Veröffentlichung:	[New York] Elsevier/North-Holland., 2019
Medientyp:	academicJournal
ISSN:	1879-1166 (electronic)
DOI:	10.1016/j.humimm.2019.07.287
Schlagwort:	Adult Aged Aged, 80 and over Alleles Biomarkers Female Gene Frequency genetics Genetic Loci HLA Antigens genetics Haplotypes genetics Humans Male Polymorphism, Genetic Population genetics Young Adult Aging genetics Aging immunology Education High-Throughput Nucleotide Sequencing Immunogenetics methods
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: English Publication Type: Journal Article Language: English [Hum Immunol] 2019 Sep; Vol. 80 (9), pp. 703-713. <i>Date of Electronic Publication: </i>2019 Jul 20. MeSH Terms: Education* ; High-Throughput Nucleotide Sequencing* ; Aging / genetics ; Aging / immunology ; Immunogenetics / *methods ; Adult ; Aged ; Aged, 80 and over ; Alleles ; Biomarkers ; Female ; Gene Frequency / genetics ; Genetic Loci ; HLA Antigens / genetics ; Haplotypes / genetics ; Humans ; Male ; Polymorphism, Genetic ; Population / genetics ; Young Adult References: Trends Immunol. 2004 Jan;25(1):4-7. (PMID: 14698276) ; Am J Med Genet. 2001 Sep 1;102(4):346-52. (PMID: 11503162) ; J Am Geriatr Soc. 1999 Sep;47(9):1136-44. (PMID: 10484259) ; J Gerontol. 1993 Nov;48(6):B237-44. (PMID: 8227991) ; Hum Genet. 1999 Oct;105(4):337-42. (PMID: 10543402) ; Tissue Antigens. 2007 Apr;69 Suppl 1:192-7. (PMID: 17445199) ; Immun Ageing. 2005 Nov 03;2:13. (PMID: 16269080) ; J Pediatr Endocrinol Metab. 2000;13 Suppl 6:1477-81. (PMID: 11202224) ; Mech Ageing Dev. 2003 Apr;124(4):533-8. (PMID: 12714264) ; Hum Mol Genet. 1998 Feb;7(2):187-94. (PMID: 9425225) ; Lancet. 1987 Oct 10;2(8563):824-6. (PMID: 2889033) ; Hum Genet. 1996 Mar;97(3):319-23. (PMID: 8786073) ; Ann N Y Acad Sci. 1991;621:78-89. (PMID: 1859103) ; Mech Ageing Dev. 1984 Nov;28(1):47-55. (PMID: 6513613) ; Front Oncol. 2013 Dec 12;3:300. (PMID: 24377085) ; Tissue Antigens. 2011 Mar;77(3):187-92. (PMID: 21299522) ; World J Gastroenterol. 2007 Mar 28;13(12):1770-87. (PMID: 17465466) ; Cerebrovasc Dis. 2004;17 Suppl 3:1-5. (PMID: 14730251) ; Leuk Lymphoma. 2010 Jul;51(7):1288-92. (PMID: 20388056) ; Biomed Res Int. 2013;2013:705862. (PMID: 24364037) ; Ann N Y Acad Sci. 2006 Nov;1089:516-37. (PMID: 17261795) ; Tissue Antigens. 2007 Apr;69 Suppl 1:304-10. (PMID: 17445222) ; Int J Immunogenet. 2011 Oct;38(5):373-81. (PMID: 21726414) ; Aging (Albany NY). 2018 Mar 15;10(3):515. (PMID: 29615541) ; Int J Immunogenet. 2013 Feb;40(1):77-81. (PMID: 23302099) ; Nat Med. 1995 Dec;1(12):1279-83. (PMID: 7489409) ; J Gerontol A Biol Sci Med Sci. 1995 Nov;50(6):B378-82. (PMID: 7583794) ; Ann N Y Acad Sci. 2000 Jun;908:244-54. (PMID: 10911963) ; Mech Ageing Dev. 1997 Mar;94(1-3):191-8. (PMID: 9147371) ; Proc Natl Acad Sci U S A. 2002 Jun 11;99(12):8442-7. (PMID: 12060785) ; J Am Geriatr Soc. 1994 Sep;42(9):978-83. (PMID: 8064108) ; C R Seances Soc Biol Fil. 1997;191(4):553-62. (PMID: 9404458) ; Genet Epidemiol. 1995;12(5):529-38. (PMID: 8557185) Grant Information: U19 NS095774 United States NS NINDS NIH HHS Contributed Indexing: Keywords: Ageing; HLA; Longevity; NGS Substance Nomenclature: 0 (Biomarkers) ; 0 (HLA Antigens) Entry Date(s): Date Created: 20190724 Date Completed: 20200226 Latest Revision: 20200901 Update Code: 20231215 PubMed Central ID: PMC6773488

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17th IHIW component "Immunogenetics of Ageing" - New NGS data.