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Background: High-sensitivity C-reactive protein (hs-CRP) is a common risk factor for developing cardiovascular disease. However, there has been no study reporting the relationship between hs-CRP and blood pressure in Yi adults. The aim of this study is to investigate the association between hs-CRP and blood pressure in Yi adults.

Methods: In this cross-sectional study, included subjects were 2916 Yi migrants or farmers aged 20-80 years, recruited by using a stratified cluster sampling method from Liangshan Yi Autonomous Prefecture of Sichuan Province in 2014. The directed acyclic graphs(DAG) was used to select a minimal sufficient adjustment sets of variables which would identification the unconfounded effect of hs-CRP and hypertension. Multiple linear and multinomial logit analysis were used to estimate the effect of hs-CRP on SBP/DBP/MAP/PP and the prevalence of prehypertension/hypertension after adjustment for the relevant confounders.

Results: The median level of hs-CRP was 1.20 (0.50-3.06)mg/L in Yi migrants, and 0.84(0.36-2.52) mg/L in Yi farmers, and the prevalence of high hs-CRP was 23.25%. For hs-CRP > 3 mg/L group, the adjusted PP tended to have lower values (β = - 1.49, 95%CI: - 2.49--0.49, P = 0.0034) compared with < 1 mg/L group. After adjusting for confounders, there were no significant association between hs-CRP and prehypertension/hypertension (P > 0.05).

Conclusions: Our results suggest that high hs-CRP is prevalent in Yi people, and this study does not support hs-CRP as a risk factor of prehypertension or hypertension.

Titel:	The association between high-sensitivity C-reactive protein and blood pressure in Yi people.
Autor/in / Beteiligte Person:	Pan, L ; Li, G ; Wan, S ; Yihuo, W ; Yang, F ; Li, Z ; Shan, G
Link:	Full Text Finder (Volltext)
Zeitschrift:	BMC public health, Jg. 19 (2019-07-24), Heft 1, S. 991
Veröffentlichung:	London : BioMed Central, [2001-, 2019
Medientyp:	academicJournal
ISSN:	1471-2458 (electronic)
DOI:	10.1186/s12889-019-7324-x
Schlagwort:	Adult Aged Aged, 80 and over Asian People ethnology China epidemiology Cross-Sectional Studies Female Humans Hypertension ethnology Male Middle Aged Prehypertension ethnology Prevalence Risk Factors Young Adult Blood Pressure C-Reactive Protein analysis Ethnicity statistics & numerical data Hypertension epidemiology Prehypertension epidemiology Transients and Migrants statistics & numerical data
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: English Publication Type: Evaluation Study; Journal Article Language: English [BMC Public Health] 2019 Jul 24; Vol. 19 (1), pp. 991. <i>Date of Electronic Publication: </i>2019 Jul 24. MeSH Terms: Blood Pressure* ; C-Reactive Protein / analysis ; Ethnicity / statistics & numerical data ; Hypertension / epidemiology ; Prehypertension / epidemiology ; Transients and Migrants / *statistics & numerical data ; Adult ; Aged ; Aged, 80 and over ; Asian People / ethnology ; China / epidemiology ; Cross-Sectional Studies ; Female ; Humans ; Hypertension / ethnology ; Male ; Middle Aged ; Prehypertension / ethnology ; Prevalence ; Risk Factors ; Young Adult References: Stat Med. 1999 Mar 30;18(6):681-94. (PMID: 10204197) ; J Hypertens. 2001 May;19(5):857-61. (PMID: 11393667) ; Circulation. 2002 Aug 20;106(8):913-9. (PMID: 12186793) ; Circulation. 2002 Sep 17;106(12):1439-41. (PMID: 12234944) ; Lancet. 2002 Dec 14;360(9349):1903-13. (PMID: 12493255) ; Circulation. 2003 Jan 28;107(3):398-404. (PMID: 12551862) ; Circulation. 2003 Jan 28;107(3):499-511. (PMID: 12551878) ; JAMA. 2003 May 21;289(19):2560-72. (PMID: 12748199) ; JAMA. 2003 Dec 10;290(22):2945-51. (PMID: 14665655) ; Hypertension. 2004 Dec;44(6):859-65. (PMID: 15492131) ; Circulation. 2005 Feb 8;111(5):697-716. (PMID: 15699287) ; J Hum Hypertens. 2006 Nov;20(11):850-9. (PMID: 16855625) ; Hypertension. 2007 Mar;49(3):432-8. (PMID: 17242302) ; Clin Chem. 2008 Jun;54(6):1027-37. (PMID: 18403563) ; Clin Exp Hypertens. 2008 Jul;30(5):367-74. (PMID: 18633759) ; BMC Med Res Methodol. 2008 Oct 30;8:70. (PMID: 18973665) ; Clin Chem. 2009 Feb;55(2):305-12. (PMID: 19095726) ; Ethn Dis. 2008 Autumn;18(4):427-33. (PMID: 19157246) ; Asia Pac J Clin Nutr. 2010;19(2):266-73. (PMID: 20460243) ; JAMA. 2010 May 26;303(20):2043-50. (PMID: 20501926) ; J Inflamm (Lond). 2010 Jul 26;7:36. (PMID: 20659335) ; Circ Cardiovasc Genet. 2010 Oct;3(5):436-44. (PMID: 20876875) ; Biomed Environ Sci. 2011 Oct;24(5):467-74. (PMID: 22108411) ; Clin Chem. 2012 Jan;58(1):72-82. (PMID: 22125305) ; Int J Cardiol. 2013 Jun 20;166(2):487-93. (PMID: 22240756) ; Cardiovasc Diabetol. 2012 Mar 14;11:25. (PMID: 22417460) ; Vasc Health Risk Manag. 2012;8:437-42. (PMID: 22870036) ; Cardiovasc Diabetol. 2014 Apr 09;13:76. (PMID: 24716628) ; Lancet. 2014 May 31;383(9932):1899-911. (PMID: 24881994) ; Curr Atheroscler Rep. 2015 Apr;17(4):494. (PMID: 25690588) ; Hypertens Res. 2015 Jun;38(6):426-32. (PMID: 25787035) ; Hypertension. 2016 Jan;67(1):63-9. (PMID: 26553236) ; J Am Coll Cardiol. 2016 Feb 16;67(6):712-723. (PMID: 26868696) ; Menopause. 2016 Jun;23(6):662-8. (PMID: 27093616) ; Int J Environ Res Public Health. 2016 Aug 31;13(9):. (PMID: 27589783) ; Indian J Clin Biochem. 2016 Oct;31(4):446-51. (PMID: 27605742) ; Circulation. 2018 May 29;137(22):2344-2356. (PMID: 29449338) ; BMJ Open. 2018 Oct 3;8(10):e022714. (PMID: 30287672) ; Heart. 2019 May;105(9):686-692. (PMID: 30700522) Grant Information: 81273158 National Natural Science Foundation of China Contributed Indexing: Keywords: Blood pressure; High-sensitivity C-reactive protein (hs-CRP); Yi people Substance Nomenclature: 9007-41-4 (C-Reactive Protein) Entry Date(s): Date Created: 20190726 Date Completed: 20191010 Latest Revision: 20221207 Update Code: 20240513 PubMed Central ID: PMC6657064

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The association between high-sensitivity C-reactive protein and blood pressure in Yi people.