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Aim: Obesity is a social problem due to the prevalence of the Western lifestyle. In particular, visceral fat accumulation, which is a main component of metabolic syndrome, is closely associated with the progression of atherosclerosis. This study aimed to investigate the relationships of obesity-related indices and metabolic syndrome with subclinical atherosclerosis in middle-aged untreated workers.

Methods: Employees undergoing their periodic health check-up but without previous cardiovascular events or cardiovascular medications were enrolled in this study (n=7,750). Body mass index (BMI), percent body fat, waist circumference, and visceral fat area were evaluated as obesity-related indices. Assessment of visceral fat area was performed by computed tomography (CT). Subclinical atherosclerosis was assessed by measuring arterial stiffness using cardio-ankle vascular index (CAVI) and by ultrasound examination of carotid intima-media thickness (IMT).

Results: Obesity-related indices were significantly correlated with each other and were positively associated with carotid IMT but negatively associated with CAVI in multivariate regression analysis. In a logistic regression analysis including CAVI and carotid IMT simultaneously, CAVI was negatively associated, but carotid IMT was positively associated, with obesity defined by each obesity-related index. In contrast, both CAVI and carotid IMT were positively associated with the presence of metabolic syndrome based on visceral fat accumulation.

Conclusions: Obesity-related indices were negatively associated with CAVI and positively associated with carotid IMT in middle-aged untreated workers, while both CAVI and carotid IMT were worsened in the presence of metabolic syndrome.

Titel:	Relationships of Obesity-Related Indices and Metabolic Syndrome with Subclinical Atherosclerosis in Middle-Aged Untreated Japanese Workers.
Autor/in / Beteiligte Person:	Sugiura, T ; Dohi, Y ; Takagi, Y ; Yoshikane, N ; Ito, M ; Suzuki, K ; Nagami, T ; Iwase, M ; Seo, Y ; Ohte, N
Link:	Full Text Finder (Volltext)
Zeitschrift:	Journal of atherosclerosis and thrombosis, Jg. 27 (2020-04-01), Heft 4, S. 342-352
Veröffentlichung:	Tokyo : Japan Atherosclerosis Society, 2020
Medientyp:	academicJournal
ISSN:	1880-3873 (electronic)
DOI:	10.5551/jat.50633
Schlagwort:	Atherosclerosis etiology Atherosclerosis pathology Carotid Intima-Media Thickness Cross-Sectional Studies Female Follow-Up Studies Humans Incidence Japan epidemiology Male Middle Aged Prognosis Atherosclerosis epidemiology Biomarkers analysis Metabolic Syndrome complications Obesity complications
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: English Publication Type: Journal Article Language: English [J Atheroscler Thromb] 2020 Apr 01; Vol. 27 (4), pp. 342-352. <i>Date of Electronic Publication: </i>2019 Aug 28. MeSH Terms: Atherosclerosis / epidemiology ; Biomarkers / analysis ; Metabolic Syndrome / complications ; Obesity / complications ; Atherosclerosis / etiology ; Atherosclerosis / pathology ; Carotid Intima-Media Thickness ; Cross-Sectional Studies ; Female ; Follow-Up Studies ; Humans ; Incidence ; Japan / epidemiology ; Male ; Middle Aged ; Prognosis References: Circ J. 2014;78(12):2807-18. (PMID: 25391910) ; Hypertension. 2003 Oct;42(4):468-73. (PMID: 12953016) ; Am J Public Health. 2000 Aug;90(8):1260-8. (PMID: 10937007) ; BMJ Open. 2017 Sep 27;7(9):e016422. (PMID: 28963288) ; Physiol Rev. 2013 Jan;93(1):359-404. (PMID: 23303913) ; Hypertens Res. 2008 Oct;31(10):1921-30. (PMID: 19015600) ; Obes Res Clin Pract. 2013 Mar-Apr;7(2):e139-e145. (PMID: 24331775) ; J Hypertens. 2005 Oct;23(10):1839-46. (PMID: 16148607) ; J Atheroscler Thromb. 2012;19(6):570-6. (PMID: 22472214) ; Arterioscler Thromb Vasc Biol. 2008 Jun;28(6):1039-49. (PMID: 18356555) ; J Atheroscler Thromb. 2018 Sep 1;25(9):790-791. (PMID: 29769454) ; JAMA. 2005 Apr 20;293(15):1861-7. (PMID: 15840860) ; J Atheroscler Thromb. 2006 Apr;13(2):101-7. (PMID: 16733298) ; Atherosclerosis. 2015 Oct;242(2):461-8. (PMID: 26295798) ; Atherosclerosis. 2007 Dec;195(2):e190-4. (PMID: 17678931) ; Nihon Naika Gakkai Zasshi. 2005 Apr 10;94(4):794-809. (PMID: 15865013) ; Ann Nutr Metab. 2015;66 Suppl 2:7-12. (PMID: 26045323) ; Cardiovasc Diabetol. 2016 Oct 24;15(1):148. (PMID: 27776526) ; Metabolism. 2009 Jul;58(7):1023-9. (PMID: 19376553) ; JAMA. 2002 Jan 16;287(3):356-9. (PMID: 11790215) ; Hypertension. 2013 Jun;61(6):1322-7. (PMID: 23608657) ; J Am Coll Cardiol. 2012 Feb 14;59(7):635-43. (PMID: 22322078) ; PLoS One. 2017 Oct 26;12(10):e0186863. (PMID: 29073198) ; Am J Clin Nutr. 2005 Jan;81(1):74-8. (PMID: 15640463) ; BMJ Open. 2018 Jan 5;8(1):e019370. (PMID: 29306892) ; Medicine (Baltimore). 2017 Aug;96(31):e7710. (PMID: 28767608) ; J Pediatr. 2015 Aug;167(2):361-365.e1. (PMID: 26003881) ; Hypertens Res. 2014 Apr;37(4):253-390. (PMID: 24705419) ; Circulation. 2009 Oct 20;120(16):1640-5. (PMID: 19805654) ; Am J Med. 2007 Feb;120(2 Suppl 1):S3-8; discussion S29-32. (PMID: 17296343) ; Obes Rev. 2007 May;8(3):191-6. (PMID: 17444961) ; N Engl J Med. 1998 Nov 12;339(20):1415-25. (PMID: 9811916) ; J Diabetes Investig. 2010 Oct 19;1(5):212-28. (PMID: 24843435) ; J Atheroscler Thromb. 2016;23(1):18-31. (PMID: 26460381) ; Clin Chim Acta. 2013 Mar 15;418:63-71. (PMID: 23318564) ; J Atheroscler Thromb. 2016;23(2):155-68. (PMID: 26607350) ; Lancet. 2014 Aug 30;384(9945):766-81. (PMID: 24880830) ; Arterioscler Thromb Vasc Biol. 2015 Apr;35(4):1038-44. (PMID: 25633314) ; Braz J Med Biol Res. 2012 Jul;45(7):591-600. (PMID: 22510779) ; J Atheroscler Thromb. 2019 May 1;26(5):476-487. (PMID: 30344204) ; J Atheroscler Thromb. 2017 Nov 1;24(11):1186-1198. (PMID: 28674322) ; Vasc Health Risk Manag. 2016 Dec 21;13:1-9. (PMID: 28053538) ; Int J Obes (Lond). 2010 May;34(5):791-9. (PMID: 20125098) ; Circ J. 2002 Nov;66(11):987-92. (PMID: 12419927) ; J Atheroscler Thromb. 2007 Aug;14(4):155-8. (PMID: 17827859) ; Clin Nutr. 2010 Oct;29(5):560-6. (PMID: 20359792) ; Circulation. 2005 Oct 25;112(17):2735-52. (PMID: 16157765) ; Int J Obes (Lond). 2008 Jun;32(6):959-66. (PMID: 18283284) ; Int J Obes (Lond). 2012 Feb;36(2):286-94. (PMID: 21587201) ; Public Health Nutr. 2009 Apr;12(4):497-506. (PMID: 18547457) ; Can J Public Health. 2017 Mar 01;107(6):e520-e525. (PMID: 28252369) ; Postgrad Med. 2017 Mar;129(2):224-230. (PMID: 27915493) Contributed Indexing: Keywords: Atherosclerosis; Cardio-ankle vascular index; Carotid intima-media thickness; Metabolic syndrome; Obesity Substance Nomenclature: 0 (Biomarkers) Entry Date(s): Date Created: 20190830 Date Completed: 20210126 Latest Revision: 20210126 Update Code: 20231215 PubMed Central ID: PMC7192820

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Relationships of Obesity-Related Indices and Metabolic Syndrome with Subclinical Atherosclerosis in Middle-Aged Untreated Japanese Workers.