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Genipin is one of the major component in Gardenis fruit, which has long been used in the treatment of many chronic diseases, such as colitis. In the present study, we investigated the protective effects and mechanism of genipin on dextran sodium sulfate (DSS)-induced colitis in mice. Colitis was induced by giving 2.5% (wt/vol) DSS for 7 days. As the results show, DSS-induced body weight loss and colonic histological changes were inhibited by the treatment of genipin. DSS-induced MPO activity, MDA level, TNF-α, and IL-1β production in colonic tissues were also suppressed by genipin. To investigate the mechanism of genipin on DSS-induced colitis, the NF-κB and Nrf2 signaling pathways were detected. The results showed genipin significantly attenuated DSS-induced NF-κB activation and increased the expression of Nrf2 and HO-1 in a dose-dependent manner. The results of the present study indicated that genipin protected mice against colitis through inhibiting inflammatory and oxidative effects.

Titel:	Genipin attenuates dextran sulfate sodium-induced colitis via suppressing inflammatory and oxidative responses.
Autor/in / Beteiligte Person:	Li, Z ; Ma, T ; Zhang, W ; Shang, Y ; Zhang, Y ; Ma, Y
Link:	Full Text Finder (Volltext)
Zeitschrift:	Inflammopharmacology, Jg. 28 (2020-02-01), Heft 1, S. 333-339
Veröffentlichung:	Basel ; Boston : Birkhäuser ; <i>Original Publication</i>: Dordrecht, The Netherlands ; Norwell, MA, USA : Kluwer Academic Publishers, c1991-, 2020
Medientyp:	academicJournal
ISSN:	1568-5608 (electronic)
DOI:	10.1007/s10787-019-00639-9
Schlagwort:	Animals Colitis chemically induced Colitis metabolism Colon drug effects Colon metabolism Cytokines metabolism Dextran Sulfate pharmacology Inflammation metabolism Inflammation Mediators metabolism Interleukin-1beta metabolism Male Mice Mice, Inbred C57BL NF-E2-Related Factor 2 metabolism NF-kappa B metabolism Signal Transduction drug effects Tumor Necrosis Factor-alpha metabolism Colitis drug therapy Inflammation drug therapy Iridoids pharmacology Oxidative Stress drug effects
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: English Publication Type: Journal Article Language: English [Inflammopharmacology] 2020 Feb; Vol. 28 (1), pp. 333-339. <i>Date of Electronic Publication: </i>2019 Oct 23. MeSH Terms: Colitis / drug therapy ; Inflammation / drug therapy ; Iridoids / pharmacology ; Oxidative Stress / drug effects ; Animals ; Colitis / chemically induced ; Colitis / metabolism ; Colon / drug effects ; Colon / metabolism ; Cytokines / metabolism ; Dextran Sulfate / pharmacology ; Inflammation / metabolism ; Inflammation Mediators / metabolism ; Interleukin-1beta / metabolism ; Male ; Mice ; Mice, Inbred C57BL ; NF-E2-Related Factor 2 / metabolism ; NF-kappa B / metabolism ; Signal Transduction / drug effects ; Tumor Necrosis Factor-alpha / metabolism References: Gut. 1996 Aug;39(2):234-41. (PMID: 8991862) ; Front Immunol. 2015 Nov 02;6:551. (PMID: 26579126) ; Food Chem Toxicol. 2012 Sep;50(9):2978-86. (PMID: 22687549) ; Gastroenterology. 1999 Nov;117(5):1089-97. (PMID: 10535871) ; PLoS One. 2012;7(3):e34122. (PMID: 22479539) ; Biopharm Drug Dispos. 2009 Oct;30(7):345-55. (PMID: 19725016) ; Gastroenterology. 2008 Mar;134(3):680-7. (PMID: 18242604) ; J Immunol. 2004 Sep 15;173(6):4197-206. (PMID: 15356171) ; Eur J Pharmacol. 2010 Jun 10;635(1-3):188-93. (PMID: 20303938) ; Cells. 2019 Apr 30;8(5):. (PMID: 31052214) ; Physiol Rev. 2014 Apr;94(2):329-54. (PMID: 24692350) ; N Engl J Med. 1997 Apr 10;336(15):1066-71. (PMID: 9091804) ; Inflamm Bowel Dis. 2009 Mar;15(3):341-52. (PMID: 18942757) ; Int Immunopharmacol. 2016 Sep;38:115-9. (PMID: 27262946) ; Sci Rep. 2016 May 24;6:26585. (PMID: 27215610) ; Cancer Res. 2006 Dec 15;66(24):11580-4. (PMID: 17178849) ; Inflamm Bowel Dis. 2000 Aug;6(3):206-13. (PMID: 10961593) ; J Clin Invest. 2008 Feb;118(2):560-70. (PMID: 18219394) ; Neurochem Res. 2017 Oct;42(10):2769-2776. (PMID: 28497344) ; Carcinogenesis. 2003 Mar;24(3):353-62. (PMID: 12663492) ; Nat Rev Immunol. 2008 Jun;8(6):458-66. (PMID: 18500230) ; Biofactors. 2015 Jan-Feb;41(1):1-14. (PMID: 25545372) ; Exp Biol Med (Maywood). 2012 May;237(5):474-80. (PMID: 22442342) ; Nutr Cancer. 2009;61(6):847-54. (PMID: 20155626) ; Saudi J Gastroenterol. 2012 Jan-Feb;18(1):3-10. (PMID: 22249085) ; J Dairy Sci. 2016 Apr;99(4):3016-3022. (PMID: 26851851) ; PLoS One. 2012;7(3):e32084. (PMID: 22427817) ; Am J Respir Cell Mol Biol. 1997 Jul;17(1):3-9. (PMID: 9224203) Contributed Indexing: Keywords: Colitis; DSS; Genipin; NF-κB Substance Nomenclature: 0 (Cytokines) ; 0 (Inflammation Mediators) ; 0 (Interleukin-1beta) ; 0 (Iridoids) ; 0 (NF-E2-Related Factor 2) ; 0 (NF-kappa B) ; 0 (Tumor Necrosis Factor-alpha) ; 9042-14-2 (Dextran Sulfate) ; A3V2NE52YG (genipin) Entry Date(s): Date Created: 20191025 Date Completed: 20201117 Latest Revision: 20201117 Update Code: 20240513

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Genipin attenuates dextran sulfate sodium-induced colitis via suppressing inflammatory and oxidative responses.