| Sonstiges: |
- Nachgewiesen in: MEDLINE
- Sprachen: English
- Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
- Language: English
- [Nature] 2019 Dec; Vol. 576 (7785), pp. 143-148. <i>Date of Electronic Publication: </i>2019 Nov 27.
- MeSH Terms: Cell Differentiation / *drug effects ; Lithocholic Acid / *pharmacology ; T-Lymphocytes, Regulatory / *drug effects ; Th17 Cells / *drug effects ; Animals ; Forkhead Transcription Factors / genetics ; Forkhead Transcription Factors / immunology ; Lithocholic Acid / chemistry ; Mice ; Mice, Inbred C57BL ; Reactive Oxygen Species / metabolism ; T-Lymphocytes, Regulatory / cytology ; T-Lymphocytes, Regulatory / immunology ; T-Lymphocytes, Regulatory / metabolism ; Th17 Cells / cytology ; Th17 Cells / immunology ; Th17 Cells / metabolism
- Comments: Erratum in: Nature. 2020 Mar;579(7798):E7. (PMID: 32094662)
- References: Shapiro, H., Kolodziejczyk, A. A., Halstuch, D. & Elinav, E. Bile acids in glucose metabolism in health and disease. J. Exp. Med. 215, 383–396 (2018). (PMID: 293394455789421) ; Ridlon, J. M., Kang, D. J. & Hylemon, P. B. Bile salt biotransformations by human intestinal bacteria. J. Lipid Res. 47, 241–259 (2006). (PMID: 16299351) ; Devlin, A. S. & Fischbach, M. A. A biosynthetic pathway for a prominent class of microbiota-derived bile acids. Nat. Chem. Biol. 11, 685–690 (2015). (PMID: 261925994543561) ; Hamilton, J. P. et al. Human cecal bile acids: concentration and spectrum. Am. J. Physiol. Gastrointest. Liver Physiol. 293, G256–G263 (2007). (PMID: 17412828) ; Bernstein, H., Bernstein, C., Payne, C. M. & Dvorak, K. Bile acids as endogenous etiologic agents in gastrointestinal cancer. World J. Gastroenterol. 15, 3329–3340 (2009). (PMID: 196101332712893) ; Barrasa, J. I., Olmo, N., Lizarbe, M. A. & Turnay, J. Bile acids in the colon, from healthy to cytotoxic molecules. Toxicol. In Vitro 27, 964–977 (2013). (PMID: 23274766) ; Buffie, C. G. et al. Precision microbiome reconstitution restores bile acid mediated resistance to Clostridium difficile. Nature 517, 205–208 (2015). (PMID: 25337874) ; Duboc, H. et al. Connecting dysbiosis, bile-acid dysmetabolism and gut inflammation in inflammatory bowel diseases. Gut 62, 531–539 (2013). (PMID: 22993202) ; Martínez-Moya, P. et al. Dose-dependent antiinflammatory effect of ursodeoxycholic acid in experimental colitis. Int. Immunopharmacol. 15, 372–380 (2013). (PMID: 23246254) ; Schaap, F. G., Trauner, M. & Jansen, P. L. Bile acid receptors as targets for drug development. Nat. Rev. Gastroenterol. Hepatol. 11, 55–67 (2014). (PMID: 23982684) ; Guo, C. et al. Bile acids control inflammation and metabolic disorder through inhibition of NLRP3 inflammasome. Immunity 45, 944 (2016). (PMID: 27760343) ; Ma, C. et al. Gut microbiome-mediated bile acid metabolism regulates liver cancer via NKT cells. Science 360, eaan5931 (2018). (PMID: 297988566407885) ; Cao, W. et al. The xenobiotic transporter Mdr1 enforces T cell homeostasis in the presence of intestinal bile acids. Immunity 47, 1182–1196 (2017). (PMID: 292623515741099) ; Huh, J. R. et al. Digoxin and its derivatives suppress T H 17 cell differentiation by antagonizing RORγt activity. Nature 472, 486–490 (2011). (PMID: 214419093172133) ; Jin, L. et al. Structural basis for hydroxycholesterols as natural ligands of orphan nuclear receptor RORγ. Mol. Endocrinol. 24, 923–929 (2010). (PMID: 202031002870936) ; Santori, F. R. et al. Identification of natural RORγ ligands that regulate the development of lymphoid cells. Cell Metab. 21, 286–298 (2015). (PMID: 256511814317570) ; Soroosh, P. et al. Oxysterols are agonist ligands of RORγt and drive Th17 cell differentiation. Proc. Natl Acad. Sci. USA 111, 12163–12168 (2014). (PMID: 250923234143045) ; Esplugues, E. et al. Control of T H 17 cells occurs in the small intestine. Nature 475, 514–518 (2011). (PMID: 217654303148838) ; Huh, J. R. & Littman, D. R. Small molecule inhibitors of RORγt: targeting Th17 cells and other applications. Eur. J. Immunol. 42, 2232–2237 (2012). (PMID: 229493213609417) ; Roda, A., Minutello, A., Angellotti, M. A. & Fini, A. Bile acid structure-activity relationship: evaluation of bile acid lipophilicity using 1-octanol/water partition coefficient and reverse phase HPLC. J. Lipid Res. 31, 1433–1443 (1990). (PMID: 2280184) ; Pellicciari, R. et al. Discovery of 3α,7α,11β-trihydroxy-6α-ethyl-5β-cholan-24-oic acid (TC-100), a novel bile acid as potent and highly selective FXR agonist for enterohepatic disorders. J. Med. Chem. 59, 9201–9214 (2016). (PMID: 27652492) ; Feng, Y. et al. Control of the inheritance of regulatory T cell identity by a cis element in the Foxp3 locus. Cell 158, 749–763 (2014). (PMID: 251267834151558) ; Feng, Y. et al. A mechanism for expansion of regulatory T-cell repertoire and its role in self-tolerance. Nature 528, 132–136 (2015). (PMID: 266055294862833) ; Zheng, Y. et al. Role of conserved non-coding DNA elements in the Foxp3 gene in regulatory T-cell fate. Nature 463, 808–812 (2010). (PMID: 200721262884187) ; Arpaia, N. et al. Metabolites produced by commensal bacteria promote peripheral regulatory T-cell generation. Nature 504, 451–455 (2013). (PMID: 242267733869884) ; Josefowicz, S. Z. et al. Extrathymically generated regulatory T cells control mucosal T H 2 inflammation. Nature 482, 395–399 (2012). (PMID: 223185203485072) ; Schlenner, S. M., Weigmann, B., Ruan, Q., Chen, Y. & von Boehmer, H. Smad3 binding to the foxp3 enhancer is dispensable for the development of regulatory T cells with the exception of the gut. J. Exp. Med. 209, 1529–1535 (2012). (PMID: 229083223428940) ; Makishima, M. et al. Vitamin D receptor as an intestinal bile acid sensor. Science 296, 1313–1316 (2002). (PMID: 12016314) ; Yu, J. et al. Lithocholic acid decreases expression of bile salt export pump through farnesoid X receptor antagonist activity. J. Biol. Chem. 277, 31441–31447 (2002). (PMID: 12052824) ; Nanduri, R. et al. The active form of vitamin D transcriptionally represses Smad7 Signaling and activates extracellular signal-regulated kinase (ERK) to inhibit the differentiation of a inflammatory T helper cell subset and suppress experimental autoimmune encephalomyelitis. J. Biol. Chem. 290, 12222–12236 (2015). (PMID: 258094844424354) ; Jeffery, L. E. et al. 1,25-Dihydroxyvitamin D3 and IL-2 combine to inhibit T cell production of inflammatory cytokines and promote development of regulatory T cells expressing CTLA-4 and FoxP3. J. Immunol. 183, 5458–5467 (2009). (PMID: 19843932) ; Gorman, S. et al. Topically applied 1,25-dihydroxyvitamin D3 enhances the suppressive activity of CD4 + CD25 + cells in the draining lymph nodes. J. Immunol. 179, 6273–6283 (2007). (PMID: 17947703) ; Kang, S. W. et al. 1,25-Dihyroxyvitamin D3 promotes FOXP3 expression via binding to vitamin D response elements in its conserved noncoding sequence region. J. Immunol. 188, 5276–5282 (2012). (PMID: 22529297) ; Etchegaray, J. P. & Mostoslavsky, R. Interplay between metabolism and epigenetics: a nuclear adaptation to environmental changes. Mol. Cell 62, 695–711 (2016). (PMID: 272592024893201) ; Gerriets, V. A. & Rathmell, J. C. Metabolic pathways in T cell fate and function. Trends Immunol. 33, 168–173 (2012). (PMID: 223427413319512) ; Buck, M. D., O’Sullivan, D. & Pearce, E. L. T cell metabolism drives immunity. J. Exp. Med. 212, 1345–1360 (2015). (PMID: 262612664548052) ; Gerriets, V. A. et al. Metabolic programming and PDHK1 control CD4 + T cell subsets and inflammation. J. Clin. Invest. 125, 194–207 (2015). (PMID: 25437876) ; Xu, T. et al. Metabolic control of T H 17 and induced T reg cell balance by an epigenetic mechanism. Nature 548, 228–233 (2017). (PMID: 287837316701955) ; Zhang, D. et al. d-mannose induces regulatory T cells and suppresses immunopathology. Nat. Med. 23, 1036–1045 (2017). (PMID: 28759052) ; Sena, L. A. et al. Mitochondria are required for antigen-specific T cell activation through reactive oxygen species signaling. Immunity 38, 225–236 (2013). (PMID: 234159113582741) ; Angelin, A. et al. Foxp3 reprograms T cell metabolism to function in low-glucose, high-lactate environments. Cell Metab. 25, 1282–1293 (2017). (PMID: 284161945462872) ; Robb, E. L. et al. Selective superoxide generation within mitochondria by the targeted redox cycler MitoParaquat. Free Radic. Biol. Med. 89, 883–894 (2015). (PMID: 26454075) ; Ivanov, I. I. et al. Induction of intestinal Th17 cells by segmented filamentous bacteria. Cell 139, 485–498 (2009). (PMID: 198360682796826) ; Gagliani, N. et al. T H 17 cells transdifferentiate into regulatory T cells during resolution of inflammation. Nature 523, 221–225 (2015). (PMID: 259240644498984) ; Trauner, M., Meier, P. J. & Boyer, J. L. Molecular pathogenesis of cholestasis. N. Engl. J. Med. 339, 1217–1227 (1998). (PMID: 9780343) ; Vavassori, P., Mencarelli, A., Renga, B., Distrutti, E. & Fiorucci, S. The bile acid receptor FXR is a modulator of intestinal innate immunity. J. Immunol. 183, 6251–6261 (2009). (PMID: 19864602) ; Pols, T. W. et al. TGR5 activation inhibits atherosclerosis by reducing macrophage inflammation and lipid loading. Cell Metab. 14, 747–757 (2011). (PMID: 221523033627293) ; Kakiyama, G. et al. A simple and accurate HPLC method for fecal bile acid profile in healthy and cirrhotic subjects: validation by GC-MS and LC-MS. J. Lipid Res. 55, 978–990 (2014). (PMID: 246271293995475) ; Sakai, K., Makino, T., Kawai, Y. & Mutai, M. Intestinal microflora and bile acids. Effect of bile acids on the distribution of microflora and bile acid in the digestive tract of the rat. Microbiol. Immunol. 24, 187–196 (1980). (PMID: 6447830) ; Robben, J., Caenepeel, P., Van Eldere, J. & Eyssen, H. Effects of intestinal microbial bile salt sulfatase activity on bile salt kinetics in gnotobiotic rats. Gastroenterology 94, 494–502 (1988). (PMID: 3335321) ; Yao, L. et al. A selective gut bacterial bile salt hydrolase alters host metabolism. eLife 7, e37182 (2018). (PMID: 300148526078496) ; van der Windt, G. J., Chang, C. H. & Pearce, E. L. Measuring bioenergetics in T cells using a seahorse extracellular flux analyzer. Curr. Protoc. Immunol. 113, 3.16B.1–13.16B.14 (2016). ; Powrie, F. et al. Inhibition of Th1 responses prevents inflammatory bowel disease in scid mice reconstituted with CD45RB hi CD4 + T cells. Immunity 1, 553–562 (1994). (PMID: 7600284) ; Bokulich, N. A. et al. Optimizing taxonomic classification of marker-gene amplicon sequences with QIIME 2’s q2-feature-classifier plugin. Microbiome 6, 90 (2018). (PMID: 297730785956843) ; Bolyen, E. et al. An introduction to applied bioinformatics: a free, open, and interactive text. J Open Source Educ 1, 27 (2018). (PMID: 306878456343836) ; Callahan, B. J. et al. DADA2: high-resolution sample inference from Illumina amplicon data. Nat. Methods 13, 581–583 (2016). (PMID: 272140474927377)
- Grant Information: R01 DK110559 United States DK NIDDK NIH HHS; United States HHMI Howard Hughes Medical Institute; P30 DK034854 United States DK NIDDK NIH HHS; R01 AI107027 United States AI NIAID NIH HHS; 210664/Z/18/Z United Kingdom WT_ Wellcome Trust; R01 DK114252 United States DK NIDDK NIH HHS; R01 DK103358 United States DK NIDDK NIH HHS; R01 AI080885 United States AI NIAID NIH HHS
- Substance Nomenclature: 0 (Forkhead Transcription Factors) ; 0 (Foxp3 protein, mouse) ; 0 (Reactive Oxygen Species) ; 5QU0I8393U (Lithocholic Acid)
- Entry Date(s): Date Created: 20191129 Date Completed: 20200326 Latest Revision: 20230315
- Update Code: 20231215
- PubMed Central ID: PMC6949019
|
