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The causal and functional connection between inflammation and cancer has become a subject of much research interest. Modulation of cell signaling pathways, such as those involving mitogen activated protein kinases (MAPKs), nuclear factor kappa β (NF-κB), phosphatidylinositol 3-kinase and protein kinase B (PI3K/Akt), and Wnt, and their outcomes play a fundamental role in inflammation and cancer. Activation of these cell signaling pathways can lead to various aspects of cancer-related inflammation. Hence, compounds able to modulate inflammation-related molecular targets are sought after in anticancer drug development programs. In recent years, plant extracts and their metabolites have been documented with potential in the prevention and treatment of cancer and inflammatory ailments. Plants possessing anticancer and anti-inflammatory properties due to their bioactive constituents have been reported to modulate the molecular and cellular pathways which are related to inflammation and cancer. In this review we focus on the flavonoids (astragalin, kaempferol, quercetin, rutin), lignans (phyllanthin, hypophyllanthin, and niranthin), tannins (corilagin, geraniin, ellagic acid, gallic acid), and triterpenes (lupeol, oleanolic acid, ursolic acid) of Phyllanthus amarus, which exert various anticancer and anti-inflammatory activities via perturbation of the NF-κB, MAPKs, PI3K/Akt, and Wnt signaling networks. Understanding the underlying mechanisms involved may help future research to develop drug candidates for prevention and new treatment for cancer and inflammatory diseases.

Titel:	Modulation of cell signaling pathways by Phyllanthus amarus and its major constituents: potential role in the prevention and treatment of inflammation and cancer.
Autor/in / Beteiligte Person:	Harikrishnan, H ; Jantan, I ; Alagan, A ; Haque, MA
Link:	Full Text Finder (Volltext)
Zeitschrift:	Inflammopharmacology, Jg. 28 (2020-02-01), Heft 1, S. 1-18
Veröffentlichung:	Basel ; Boston : Birkhäuser ; <i>Original Publication</i>: Dordrecht, The Netherlands ; Norwell, MA, USA : Kluwer Academic Publishers, c1991-, 2020
Medientyp:	academicJournal
ISSN:	1568-5608 (electronic)
DOI:	10.1007/s10787-019-00671-9
Schlagwort:	Animals Anti-Inflammatory Agents pharmacology Anti-Inflammatory Agents therapeutic use Humans Inflammation drug therapy Neoplasms drug therapy Phyllanthus chemistry Plant Extracts pharmacology Plant Extracts therapeutic use Signal Transduction drug effects
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: English Publication Type: Journal Article; Review Language: English [Inflammopharmacology] 2020 Feb; Vol. 28 (1), pp. 1-18. <i>Date of Electronic Publication: </i>2019 Dec 02. MeSH Terms: Inflammation / drug therapy ; Neoplasms / drug therapy ; Phyllanthus / chemistry ; Plant Extracts / pharmacology ; Plant Extracts / therapeutic use ; Signal Transduction / drug effects ; Animals ; Anti-Inflammatory Agents / pharmacology ; Anti-Inflammatory Agents / therapeutic use ; Humans References: Biomed Pharmacother. 2018 Mar;99:319-324. (PMID: 29353207) ; J Biol Chem. 2002 Jul 12;277(28):24889-95. (PMID: 11978785) ; J Med Food. 2004 Fall;7(3):274-83. (PMID: 15383219) ; Biochem Pharmacol. 2010 Dec 15;80(12):2042-9. (PMID: 20599768) ; Bioorg Med Chem. 2005 Dec 1;13(23):6470-6. (PMID: 16143535) ; Phytother Res. 2018 Dec;32(12):2510-2519. (PMID: 30238535) ; Int Immunopharmacol. 2013 Oct;17(2):478-82. 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(PMID: 19557821) Grant Information: NH1015D075 Kementerian Pertanian dan Industri Asas Tani Malaysia Contributed Indexing: Keywords: Anti-inflammation; Anticancer; Phyllanthus amarus; Secondary metabolites; Signaling pathways Substance Nomenclature: 0 (Anti-Inflammatory Agents) ; 0 (Plant Extracts) Entry Date(s): Date Created: 20191204 Date Completed: 20201117 Latest Revision: 20201117 Update Code: 20231215

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Modulation of cell signaling pathways by Phyllanthus amarus and its major constituents: potential role in the prevention and treatment of inflammation and cancer.