Einzeltreffer — DigiBib

Obesity is a serious medical condition worldwide, which needs new approaches and recognized international consensus in treating diseases leading to morbidity. The aim of this review was to examine heterogeneous links among the various phenotypes of obesity in adults. Proteins and associated genes in each group were analysed to differentiate between biomarkers. A variety of terms for classification and characterization within this pathology are currently in use; however, there is no clear consensus in terminology. The most significant groups reviewed include metabolically healthy obese, metabolically abnormal obese, metabolically abnormal, normal weight and sarcopenic obese. These phenotypes do not define particular genotypes or epigenetic gene regulation, or proteins related to inflammation. There are many other genes linked to obesity, though the value of screening all of those for diagnosis has low predictive results, as there are no significant biomarkers. It is important to establish a consensus in the terminology used and the characteristics attributed to obesity subtypes. The identification of specific molecular biomarkers is also required for better diagnosis in subtypes of obesity.

Competing Interests: None

Titel:	Obesity subtypes, related biomarkers & heterogeneity.
Autor/in / Beteiligte Person:	Mayoral, LP ; Andrade, GM ; Mayoral, EP ; Huerta, TH ; Canseco, SP ; Rodal Canales, FJ ; Cabrera-Fuentes, HA ; Cruz, MM ; Pérez Santiago, AD ; Alpuche, JJ ; Zenteno, E ; Ruíz, HM ; Cruz, RM ; Jeronimo, JH ; Perez-Campos, E
Link:	Full Text Finder (Volltext)
Zeitschrift:	The Indian journal of medical research, Jg. 151 (2020), Heft 1, S. 11-21
Veröffentlichung:	<2011- > : Mumbai : Medknow ; <i>Original Publication</i>: New Delhi : Council Of Medical Research, 2020
Medientyp:	academicJournal
ISSN:	0971-5916 (print)
DOI:	10.4103/ijmr.IJMR_1768_17
Schlagwort:	Adult Genotype Humans Obesity classification Obesity epidemiology Phenotype Biomarkers Obesity diagnosis Obesity genetics Proteins genetics
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: English Publication Type: Journal Article; Review Language: English [Indian J Med Res] 2020 Jan; Vol. 151 (1), pp. 11-21. MeSH Terms: Biomarkers* ; Obesity / diagnosis ; Obesity / genetics ; Proteins / *genetics ; Adult ; Genotype ; Humans ; Obesity / classification ; Obesity / epidemiology ; Phenotype References: PLoS One. 2016 Mar 23;11(3):e0151329. (PMID: 27008626) ; Curr Opin Clin Nutr Metab Care. 2018 Sep;21(5):366-374. (PMID: 29957677) ; Clin Sci (Lond). 2016 Jun 1;130(12):943-86. (PMID: 27154742) ; J Cachexia Sarcopenia Muscle. 2016 Jun;7(3):312-21. (PMID: 27239412) ; Cardiovasc Diabetol. 2012 Apr 26;11:43. (PMID: 22537054) ; Exp Mol Med. 2016 Mar 11;48:e215. (PMID: 26964831) ; Nutrients. 2016 Jun 01;8(6):. (PMID: 27258304) ; Eur Heart J. 2010 Mar;31(6):737-46. (PMID: 19933515) ; Circ Res. 2005 May 13;96(9):939-49. (PMID: 15890981) ; Obes Facts. 2012;5(5):734-44. (PMID: 23108472) ; Diabetes Metab Syndr. 2016 Apr-Jun;10(2 Suppl 1):S82-8. (PMID: 26960924) ; J Nutr Health Aging. 2014;18(6):586-90. (PMID: 24950148) ; PLoS Genet. 2007 Jul;3(7):e115. (PMID: 17658951) ; J Clin Epidemiol. 2008 Jul;61(7):646-53. (PMID: 18359190) ; Vitam Horm. 2013;91:49-75. (PMID: 23374712) ; Genes Dev. 2008 May 15;22(10):1269-75. (PMID: 18483216) ; Science. 2007 May 11;316(5826):889-94. (PMID: 17434869) ; Arq Gastroenterol. 2010 Apr-Jun;47(2):165-9. (PMID: 20721461) ; J Cardiol. 2007 Sep;50(3):175-82. (PMID: 17941193) ; J Lipid Res. 2017 Jan;58(1):289-298. (PMID: 27845688) ; Int J Obes (Lond). 2016 Apr;40(4):654-61. (PMID: 26499446) ; Endocrinol Nutr. 2011 Oct;58(8):422-32. (PMID: 21824829) ; Arch Intern Med. 2008 Aug 11;168(15):1617-24. (PMID: 18695075) ; Proc Natl Acad Sci U S A. 2006 Apr 25;103(17):6676-81. (PMID: 16617105) ; Dis Markers. 2013;35(6):615-23. (PMID: 24285913) ; Can J Cardiol. 2007 Oct;23 Suppl B:23B-31B. (PMID: 17932584) ; Prog Mol Biol Transl Sci. 2016;140:185-231. (PMID: 27288830) ; Diabetes Metab Syndr Obes. 2015 Mar 06;8:147-56. (PMID: 25834460) ; Nutrients. 2015 Sep 11;7(9):7676-90. (PMID: 26378572) ; EMBO Rep. 2004 Jul;5(7):650-3. (PMID: 15229637) ; Dis Markers. 2014;2014:743634. (PMID: 25371596) ; Nat Genet. 2010 Nov;42(11):937-48. (PMID: 20935630) ; PLoS One. 2013;8(3):e60673. (PMID: 23556000) ; Circ Heart Fail. 2015 Sep;8(5):897-904. (PMID: 26175540) ; Ann Intern Med. 2015 Dec 1;163(11):827-35. (PMID: 26551006) ; PLoS One. 2012;7(4):e33308. (PMID: 22485140) ; Circulation. 2009 Oct 20;120(16):1640-5. (PMID: 19805654) ; J Am Coll Cardiol. 2014 Jun 24;63(24):2679-86. (PMID: 24794119) ; Clin Interv Aging. 2015 Mar 25;10:605-9. (PMID: 25848236) ; BMC Med Genomics. 2015;8 Suppl 1:S2. (PMID: 25951849) ; J Clin Hypertens (Greenwich). 2010 Apr;12(4):301-8. (PMID: 20433554) ; J Magn Reson Imaging. 2011 Oct;34(4):729-749. (PMID: 22025886) ; Obes Surg. 2015 Aug;25(8):1380-91. (PMID: 25515498) ; Nutr Metab Cardiovasc Dis. 2015 Jan;25(1):100-7. (PMID: 25159728) ; Korean J Pediatr. 2016 Nov;59(11):425-431. (PMID: 27895689) ; Diabetologia. 2013 Nov;56(11):2487-97. (PMID: 24013717) ; Br J Nutr. 2016 Jan 14;115(1):185-92. (PMID: 26489926) ; Am J Clin Nutr. 2005 Jul;82(1):49-52. (PMID: 16002799) ; PLoS One. 2014 Feb 10;9(2):e88539. (PMID: 24520395) ; PLoS One. 2008;3(12):e3875. (PMID: 19060953) ; J Clin Endocrinol Metab. 2013 Oct;98(10):E1610-9. (PMID: 23979951) ; PLoS One. 2015 Jul 15;10(7):e0132908. (PMID: 26177029) ; Int J Environ Res Public Health. 2017 Apr 07;14(4):. (PMID: 28387701) ; J Am Acad Nurse Pract. 2007 May;19(5):235-41. (PMID: 17489956) ; Diabetes. 2014 Dec;63(12):4369-77. (PMID: 25048195) ; Am J Clin Nutr. 2007 Jan;85(1):40-5. (PMID: 17209175) ; Mol Aspects Med. 2013 Feb;34(1):1-11. (PMID: 23068073) ; Appl Physiol Nutr Metab. 2007 Feb;32(1):4-12. (PMID: 17332780) ; Diabetes. 1998 May;47(5):699-713. (PMID: 9588440) ; Clin Obes. 2015 Aug;5(4):211-8. (PMID: 26153357) ; Metab Syndr Relat Disord. 2016 Dec;14(10):492-499. (PMID: 27740885) ; Front Cardiovasc Med. 2014 Dec 16;1:12. (PMID: 26664862) ; N Engl J Med. 2009 Apr 9;360(15):1500-8. (PMID: 19357405) ; Int J Endocrinol. 2013;2013:204164. (PMID: 23690769) ; N C Med J. 2013 Nov-Dec;74(6):530-3. (PMID: 24316784) ; Biomed Res Int. 2015;2015:548734. (PMID: 26504811) ; Am J Epidemiol. 2010 Dec 15;172(12):1442-54. (PMID: 20952596) ; Invest Radiol. 2012 Apr;47(4):209-16. (PMID: 22233757) ; Hormones (Athens). 2017 Apr;16(2):181-193. (PMID: 28742506) ; PLoS One. 2012;7(11):e49919. (PMID: 23209618) ; Stem Cell Rev Rep. 2013 Aug;9(4):385-7. (PMID: 23892888) ; Transl Res. 2016 Dec;178:13-24.e5. (PMID: 27477082) ; Obesity (Silver Spring). 2013 Jan;21(1):203-9. (PMID: 23505187) ; Biochem J. 2009 Dec 14;425(1):71-83. (PMID: 19883376) ; Nutrition. 2001 Mar;17(3):248-53. (PMID: 11312069) ; Clin Epigenetics. 2016 Jan 20;8:6. (PMID: 26798409) ; J Korean Med Sci. 2015 Mar;30(3):264-71. (PMID: 25729248) ; Postgrad Med. 2003 Dec;114(6):19-27, 38. (PMID: 14689721) ; Obesity (Silver Spring). 2016 Mar;24(3):556-67. (PMID: 26868960) ; Basic Res Cardiol. 2016 Nov;111(6):69. (PMID: 27743118) ; PLoS One. 2014 Apr 09;9(4):e94433. (PMID: 24718033) ; Basic Res Cardiol. 2016 Jan;111(1):7. (PMID: 26667317) ; Iran J Basic Med Sci. 2012 Nov;15(6):1180-4. (PMID: 23653848) ; Obesity (Silver Spring). 2016 Jun;24(6):1257-65. (PMID: 27106679) ; Obes Rev. 2012 Mar;13(3):275-86. (PMID: 22106927) ; Br J Nutr. 2016 Aug;116(3):567-8. (PMID: 27264990) ; Epigenetics. 2015;10(11):995-1005. (PMID: 26646899) ; Int J Obes (Lond). 2008 Jun;32(6):959-66. (PMID: 18283284) ; Acta Diabetol. 2015 Oct;52(5):855-63. (PMID: 25690647) ; Nutr Metab Cardiovasc Dis. 2016 Jan;26(1):67-76. (PMID: 26631437) ; Curr Opin Clin Nutr Metab Care. 2012 Sep;15(5):436-41. (PMID: 22797572) ; Future Sci OA. 2016 Jul 14;2(3):FSO127. (PMID: 28031974) ; PLoS Med. 2011 Nov;8(11):e1001114. (PMID: 22069377) ; Clin Endocrinol (Oxf). 2015 Feb;82(2):213-20. (PMID: 24841432) ; J Lipid Res. 2007 Jun;48(6):1253-62. (PMID: 17374880) ; Stem Cells Int. 2016;2016:6067349. (PMID: 27073398) Contributed Indexing: Keywords: Adipose tissue; HOMA; biomarkers; body fat; genome-wide association studies; heterogeneity; obesity; subtypes Substance Nomenclature: 0 (Biomarkers) ; 0 (Proteins) Entry Date(s): Date Created: 20200306 Date Completed: 20210118 Latest Revision: 20210118 Update Code: 20240513 PubMed Central ID: PMC7055173

Klicken Sie ein Format an und speichern Sie dann die Daten oder geben Sie eine Empfänger-Adresse ein und lassen Sie sich per Email zusenden.

BibTeX Citavi, JabRef, u.a.
(Literaturverwaltung)

PDF kein Volltext!
(Merkzettel, Notizen)

RIS Endnote, Citavi u.a.
(Literaturverwaltung)

MODS
(XML zur Weiterverarbeitung)

oder

Wählen Sie das für Sie passende Zitationsformat und kopieren Sie es dann in die Zwischenablage, lassen es sich per Mail zusenden oder speichern es als PDF-Datei.

Gewünschter Zitations-Stil:

oder

Bitte prüfen Sie, ob die Zitation formal korrekt ist, bevor Sie sie in einer Arbeit verwenden. Benutzen Sie gegebenenfalls den "Exportieren"-Dialog, wenn Sie ein Literaturverwaltungsprogramm verwenden und die Zitat-Angaben selbst formatieren wollen.

Obesity subtypes, related biomarkers & heterogeneity.