Contrasting effects of B cell depletion on CD4 <superscript>+</superscript> and CD8 <superscript>+</superscript> memory T cell responses generated after transplantation.
In: American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, Jg. 20 (2020-09-01), Heft 9, S. 2551-2558
Online
academicJournal
Zugriff:
Alloreactive memory T cells play a key role in transplantation by accelerating allograft rejection and preventing tolerance induction. Some studies using µMT mice, which are constitutionally devoid of B cells, showed that B cells were required for the generation of memory T cells after allotransplantation. However, whether B cell depletion in normal adult mice has the same effect on memory responses by CD4 + and CD8 + T cells activated after transplantation has not been thoroughly investigated. In this study, we tested the effect of anti-CD20 antibody-mediated B cell depletion on CD4 + and CD8 + memory T cell alloresponses after skin transplantation in wild-type mice. We found that B cell depletion prevented the development of memory alloresponses by CD4 + T cells but enhanced that of CD8 + memory T cells. Next, we tested the influence of B cell depletion on hematopoietic chimerism. In OT-II CD4 + anti-OVA TCR transgenic mice sensitized to ovalbumin antigen, B cell depletion also impaired allospecific memory T cell responses and thereby enhanced donor hematopoietic chimerism and T cell deletion after bone marrow transplantation. This study underscores the complexity of the relationships between B and T cells in the generation and reactivation of different memory T cell subsets after transplantation.
(© 2020 The American Society of Transplantation and the American Society of Transplant Surgeons.)
Titel: |
Contrasting effects of B cell depletion on CD4 <superscript>+</superscript> and CD8 <superscript>+</superscript> memory T cell responses generated after transplantation.
|
---|---|
Autor/in / Beteiligte Person: | Marino, J ; Gonzalez-Nolasco, B ; Wang, X ; Orent, W ; Benichou, G |
Link: | |
Zeitschrift: | American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, Jg. 20 (2020-09-01), Heft 9, S. 2551-2558 |
Veröffentlichung: | 2023- : [New York] : Elsevier ; <i>Original Publication</i>: Copenhagen : Munksgaard International Publishers, 2001-, 2020 |
Medientyp: | academicJournal |
ISSN: | 1600-6143 (electronic) |
DOI: | 10.1111/ajt.15858 |
Schlagwort: |
|
Sonstiges: |
|