Early-phase [ <superscript>18</superscript> F]PI-2620 tau-PET imaging as a surrogate marker of neuronal injury.
In: European journal of nuclear medicine and molecular imaging, Jg. 47 (2020-11-01), Heft 12, S. 2911-2922
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Zugriff:
Purpose: Second-generation tau radiotracers for use with positron emission tomography (PET) have been developed for visualization of tau deposits in vivo. For several β-amyloid and first-generation tau-PET radiotracers, it has been shown that early-phase images can be used as a surrogate of neuronal injury. Therefore, we investigated the performance of early acquisitions of the novel tau-PET radiotracer [ 18 F]PI-2620 as a potential substitute for [ 18 F]fluorodeoxyglucose ([ 18 F]FDG).
Methods: Twenty-six subjects were referred with suspected tauopathies or overlapping parkinsonian syndromes (Alzheimer's disease, progressive supranuclear palsy, corticobasal syndrome, multi-system atrophy, Parkinson's disease, multi-system atrophy, Parkinson's disease, frontotemporal dementia) and received a dynamic [ 18 F]PI-2620 tau-PET (0-60 min p.i.) and static [ 18 F]FDG-PET (30-50 min p.i.). Regional standardized uptake value ratios of early-phase images (single frame SUVr) and the blood flow estimate (R 1 ) of [ 18 F]PI-2620-PET were correlated with corresponding quantification of [ 18 F]FDG-PET (global mean/cerebellar normalization). Reduced tracer uptake in cortical target regions was also interpreted visually using 3-dimensional stereotactic surface projections by three more and three less experienced readers. Spearman rank correlation coefficients were calculated between early-phase [ 18 F]PI-2620 tau-PET and [ 18 F]FDG-PET images for all cortical regions and frequencies of disagreement between images were compared for both more and less experienced readers.
Results: Highest agreement with [ 18 F]FDG-PET quantification was reached for [ 18 F]PI-2620-PET acquisition from 0.5 to 2.5 min p.i. for global mean (lowest R = 0.69) and cerebellar scaling (lowest R = 0.63). Correlation coefficients (summed 0.5-2.5 min SUVr & R 1 ) displayed strong agreement in all cortical target regions for global mean (R SUVr 0.76, R R1 = 0.77) and cerebellar normalization (R SUVr 0.68, R R1 = 0.68). Visual interpretation revealed high regional correlations between early-phase tau-PET and [ 18 F]FDG-PET. There were no relevant differences between more and less experienced readers.
Conclusion: Early-phase imaging of [ 18 F]PI-2620 can serve as a surrogate biomarker for neuronal injury. Dynamic imaging or a dual time-point protocol for tau-PET imaging could supersede additional [ 18 F]FDG-PET imaging by indexing both the distribution of tau and the extent of neuronal injury.
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Early-phase [ <superscript>18</superscript> F]PI-2620 tau-PET imaging as a surrogate marker of neuronal injury.
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Autor/in / Beteiligte Person: | Beyer, L ; Nitschmann, A ; Barthel, H ; van Eimeren T ; Unterrainer, M ; Sauerbeck, J ; Marek, K ; Song, M ; Palleis, C ; Respondek, G ; Hammes, J ; Barbe, MT ; Onur, Ö ; Jessen, F ; Saur, D ; Schroeter, ML ; Rumpf, JJ ; Rullmann, M ; Schildan, A ; Patt, M ; Neumaier, B ; Barret, O ; Madonia, J ; Russell, DS ; Stephens, AW ; Roeber, S ; Herms, J ; Bötzel, K ; Levin, J ; Classen, J ; Höglinger, GU ; Bartenstein, P ; Villemagne, V ; Drzezga, A ; Seibyl, J ; Sabri, O ; Brendel, M |
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Zeitschrift: | European journal of nuclear medicine and molecular imaging, Jg. 47 (2020-11-01), Heft 12, S. 2911-2922 |
Veröffentlichung: | Berlin : Springer-Verlag Berlin, 2002-, 2020 |
Medientyp: | academicJournal |
ISSN: | 1619-7089 (electronic) |
DOI: | 10.1007/s00259-020-04788-w |
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