Practice survey on the use of vancomycin in pediatrics in the New Aquitaine region and guidelines of learned societies.

Introduction: Vancomycin is an old antibiotic whose use is still being debated today. The objective of this work was to establish an inventory of the use of vancomycin in the various pediatric and neonatal hospital services in the New Aquitaine region.

Materials and Methods: A declaratory practice survey was conducted in 49 pediatric and neonatal hospital units. These practices were compared with the guidelines of several learned societies.

Results: A total of 36 responses could be analyzed: 12 units (33%) used vancomycin in discontinuous administration, 18 (50%) had opted for continuous infusion, and six used it in both modalities (17%). The reported dosages were highly variable. Blood tests were performed by 26 units (72%), but the target values of the trough serum concentration were also highly variable. After dosing, all units reported adjusting the dosage and re-dosing after modification (26/26). Finally, 21 units (58%) reported taking into account the MIC of the possibly isolated bacterium.

Conclusion: Our study shows that vancomycin is used in very different ways from one unit to another, within the same region, including in ways not recommended by the main learned societies. Much work remains to be done to determine the optimal dosages of vancomycin in pediatrics, to set the serum trough concentration of vancomycin values, and to determine whether continuous infusion use is comparable to discontinuous administration in terms of efficacy.

(Copyright © 2020 French Society of Pediatrics. Published by Elsevier Masson SAS. All rights reserved.)