Sex-specific impact of patterns of imageable tumor growth on survival of primary glioblastoma patients.
In: BMC cancer, Jg. 20 (2020-05-19), Heft 1, S. 447
Online
academicJournal
Zugriff:
Background: Sex is recognized as a significant determinant of outcome among glioblastoma patients, but the relative prognostic importance of glioblastoma features has not been thoroughly explored for sex differences.
Methods: Combining multi-modal MR images, biomathematical models, and patient clinical information, this investigation assesses which pretreatment variables have a sex-specific impact on the survival of glioblastoma patients (299 males and 195 females).
Results: Among males, tumor (T1Gd) radius was a predictor of overall survival (HR = 1.027, p = 0.044). Among females, higher tumor cell net invasion rate was a significant detriment to overall survival (HR = 1.011, p < 0.001). Female extreme survivors had significantly smaller tumors (T1Gd) (p = 0.010 t-test), but tumor size was not correlated with female overall survival (p = 0.955 CPH). Both male and female extreme survivors had significantly lower tumor cell net proliferation rates than other patients (M p = 0.004, F p = 0.001, t-test).
Conclusion: Despite similar distributions of the MR imaging parameters between males and females, there was a sex-specific difference in how these parameters related to outcomes.
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Sex-specific impact of patterns of imageable tumor growth on survival of primary glioblastoma patients.
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Autor/in / Beteiligte Person: | Whitmire, P ; Rickertsen, CR ; Hawkins-Daarud, A ; Carrasco E Jr ; Lorence, J ; De Leon, G ; Curtin, L ; Bayless, S ; Clark-Swanson, K ; Peeri, NC ; Corpuz, C ; Lewis-de Los Angeles, CP ; Bendok, BR ; Gonzalez-Cuyar, L ; Vora, S ; Mrugala, MM ; Hu, LS ; Wang, L ; Porter, A ; Kumthekar, P ; Johnston, SK ; Egan, KM ; Gatenby, R ; Canoll, P ; Rubin, JB ; Swanson, KR |
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Zeitschrift: | BMC cancer, Jg. 20 (2020-05-19), Heft 1, S. 447 |
Veröffentlichung: | London : BioMed Central, [2001-, 2020 |
Medientyp: | academicJournal |
ISSN: | 1471-2407 (electronic) |
DOI: | 10.1186/s12885-020-06816-2 |
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