Einzeltreffer — DigiBib

Background: This study aimed to identify clinical and cognitive factors associated with increased risk for difficult-to-treat depression (DTD) or treatment-resistant depression (TRD).

Methods: A total of 229 adult outpatients with major depression were recruited from the mental health unit at a public hospital. Participants were subdivided into resistant and nonresistant groups according to their Maudsley Staging Model score. Sociodemographic, clinical, and cognitive (objective and subjective measures) variables were compared between groups, and a logistic regression model was used to identify the factors most associated with TRD risk.

Results: TRD group patients present higher verbal memory impairment than the nonresistant group irrespective of pharmacological treatment or depressive symptom severity. Logistic regression analysis showed that low verbal memory scores (odds ratio [OR]: 2.02; 95% confidence interval [CI]: 1.38-2.95) together with high depressive symptom severity (OR: 1.29; CI95%: 1.01-1.65) were associated with TRD risk.

Conclusions: Our findings align with neuroprogression models of depression, in which more severe patients, defined by greater verbal memory impairment and depressive symptoms, develop a more resistant profile as a result of increasingly detrimental neuronal changes. Moreover, our results support a more comprehensive approach in the evaluation and treatment of DTD in order to improve illness course. Longitudinal studies are warranted to confirm the predictive value of verbal memory and depression severity in the development of TRD.

Titel:	Is cognitive dysfunction involved in difficult-to-treat depression? Characterizing resistance from a cognitive perspective.
Autor/in / Beteiligte Person:	López-Solà, C ; Subirà, M ; Serra-Blasco, M ; Vicent-Gil, M ; Navarra-Ventura, G ; Aguilar, E ; Acebillo, S ; Palao, DJ ; Cardoner, N
Link:	Full Text Finder (Volltext)
Zeitschrift:	European psychiatry : the journal of the Association of European Psychiatrists, Jg. 63 (2020-06-23), Heft 1, S. e74
Veröffentlichung:	2020- : Cambridge : Cambridge University Press ; <i>Original Publication</i>: Paris : Editions scientifiques Elsevier, c1991-, 2020
Medientyp:	academicJournal
ISSN:	1778-3585 (electronic)
DOI:	10.1192/j.eurpsy.2020.65
Schlagwort:	Adult Depressive Disorder, Major therapy Female Humans Male Memory Middle Aged Odds Ratio Outpatients psychology Cognition Cognitive Dysfunction physiopathology Cognitive Dysfunction psychology Depressive Disorder, Major physiopathology Depressive Disorder, Major psychology Depressive Disorder, Treatment-Resistant physiopathology Depressive Disorder, Treatment-Resistant psychology
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: English Publication Type: Journal Article; Research Support, Non-U.S. Gov't Language: English [Eur Psychiatry] 2020 Jun 23; Vol. 63 (1), pp. e74. <i>Date of Electronic Publication: </i>2020 Jun 23. MeSH Terms: Cognition* ; Cognitive Dysfunction / physiopathology ; Cognitive Dysfunction / psychology ; Depressive Disorder, Major / physiopathology ; Depressive Disorder, Major / psychology ; Depressive Disorder, Treatment-Resistant / physiopathology ; Depressive Disorder, Treatment-Resistant / psychology ; Adult ; Depressive Disorder, Major / therapy ; Female ; Humans ; Male ; Memory ; Middle Aged ; Odds Ratio ; Outpatients / psychology References: Brain Behav. 2016 Jul 21;6(10):e00527. (PMID: 27781141) ; Psychol Bull. 2015 Jan;141(1):105-140. (PMID: 25365762) ; BMC Med. 2016 Jan 22;14:9. (PMID: 26801406) ; Br J Psychiatry. 1998 Jun;172:527-32. (PMID: 9828995) ; Br J Psychiatry. 2008 Sep;193(3):254-5. (PMID: 18757989) ; Am J Geriatr Psychiatry. 2008 Sep;16(9):752-9. (PMID: 18697883) ; Early Interv Psychiatry. 2017 Oct;11(5):383-392. (PMID: 26177674) ; Aust N Z J Psychiatry. 2019 Feb;53(2):109-118. (PMID: 30378447) ; J Nerv Ment Dis. 1997 Dec;185(12):748-54. (PMID: 9442186) ; J Clin Psychiatry. 2001;62 Suppl 16:10-7. (PMID: 11480879) ; J ECT. 2018 Dec;34(4):258-265. (PMID: 29613944) ; J Affect Disord. 2000 Oct;60(1):13-23. (PMID: 10940443) ; Eur Neuropsychopharmacol. 2019 Jan;29(1):46-56. (PMID: 30503099) ; Mil Med. 2017 May;182(5):e1625-e1631. (PMID: 29087904) ; Neuropsychiatr Dis Treat. 2018 Oct 29;14:2861-2877. (PMID: 30464471) ; Eur Neuropsychopharmacol. 1999 Jan;9(1-2):83-91. (PMID: 10082232) ; J Affect Disord. 2014 Sep;166:108-14. (PMID: 25012418) ; J Consult Clin Psychol. 2009 Aug;77(4):775-87. (PMID: 19634969) ; Psychiatry Res. 2006 Nov 29;145(1):39-48. (PMID: 17045658) ; Evid Based Ment Health. 2016 Feb;19(1):1-3. (PMID: 26767390) ; J Clin Psychiatry. 2014 Aug;75(8):864-76. (PMID: 25099527) ; Nord J Psychiatry. 2004;58(1):41-7. (PMID: 14985153) ; J Psychiatry Neurosci. 2004 Nov;29(6):417-26. (PMID: 15644983) ; Ann Clin Psychiatry. 2003 Mar;15(1):17-22. (PMID: 12839429) ; Encephale. 2017 Aug;43(4):354-362. (PMID: 27623117) ; Aust N Z J Psychiatry. 2007 Jan;41(1):54-61. (PMID: 17464681) ; Arch Clin Neuropsychol. 2013 May;28(3):272-81. (PMID: 23343778) ; Acta Psychiatr Scand. 2016 Dec;134(6):511-521. (PMID: 27644707) ; Eur Neuropsychopharmacol. 2012 Jul;22(7):453-68. (PMID: 22464339) ; J Affect Disord. 2012 Mar;137(1-3):35-45. (PMID: 21435727) ; J Neurol Neurosurg Psychiatry. 1960 Feb;23:56-62. (PMID: 14399272) ; J Clin Psychiatry. 2017 Feb;78(2):215-222. (PMID: 28068461) ; J Affect Disord. 2019 Mar 1;246:763-774. (PMID: 30623822) ; J Clin Psychiatry. 2014 Dec;75(12):1359-70. (PMID: 25551235) ; Front Psychiatry. 2018 Jul 26;9:337. (PMID: 30093870) ; Neuropsychology. 2010 Jan;24(1):9-34. (PMID: 20063944) ; J ECT. 2008 Mar;24(1):81-3. (PMID: 18379339) ; Neuropsychopharmacology. 2004 Dec;29(12):2266-71. (PMID: 15340392) ; J Clin Psychiatry. 2007;68 Suppl 8:17-25. (PMID: 17640154) ; Front Psychol. 2013 Oct 08;4:652. (PMID: 24115937) ; J Neural Transm (Vienna). 2008 Aug;115(8):1213-9. (PMID: 18629432) ; Biol Psychiatry. 2015 Aug 15;78(4):270-7. (PMID: 25641635) ; Can J Psychiatry. 2007 Jan;52(1):46-54. (PMID: 17444078) ; Schizophr Res. 2002 Jan 15;53(3):229-38. (PMID: 11738536) ; Neurologia. 2013 Jan-Feb;28(1):33-40. (PMID: 22652141) ; J Affect Disord. 2018 May;232:96-102. (PMID: 29481997) ; Neuropsychol Rev. 2018 Jun;28(2):216-231. (PMID: 29680959) ; Arch Clin Neuropsychol. 2009 Jun;24(4):395-411. (PMID: 19648583) ; Sci Rep. 2017 Jun 20;7(1):3901. (PMID: 28634383) ; Psychiatry Res. 2013 Dec 15;210(2):387-95. (PMID: 23910239) ; Pharmacol Rev. 2018 Jul;70(3):475-504. (PMID: 29884653) ; J Clin Med Res. 2009 Oct;1(4):202-6. (PMID: 22461869) ; Neuropsychopharmacology. 2010 Jan;35(1):86-104. (PMID: 19776728) ; Int J MS Care. 2016 Jul-Aug;18(4):183-90. (PMID: 27551243) ; J Affect Disord. 2019 Mar 1;246:241-247. (PMID: 30590286) ; Psychol Bull. 2013 Jan;139(1):81-132. (PMID: 22642228) ; Cell Tissue Res. 2018 Sep;373(3):577-604. (PMID: 29218403) ; Mol Psychiatry. 2011 Mar;16(3):252-64. (PMID: 20661246) ; J Clin Psychiatry. 2009 Feb;70(2):177-84. (PMID: 19192471) Contributed Indexing: Keywords: Cognition; difficult-to-treat depression; treatment-resistant depression; verbal memory Entry Date(s): Date Created: 20200624 Date Completed: 20210413 Latest Revision: 20240329 Update Code: 20240329 PubMed Central ID: PMC7443785

Klicken Sie ein Format an und speichern Sie dann die Daten oder geben Sie eine Empfänger-Adresse ein und lassen Sie sich per Email zusenden.

BibTeX Citavi, JabRef, u.a.
(Literaturverwaltung)

PDF kein Volltext!
(Merkzettel, Notizen)

RIS Endnote, Citavi u.a.
(Literaturverwaltung)

MODS
(XML zur Weiterverarbeitung)

oder

Wählen Sie das für Sie passende Zitationsformat und kopieren Sie es dann in die Zwischenablage, lassen es sich per Mail zusenden oder speichern es als PDF-Datei.

Gewünschter Zitations-Stil:

oder

Bitte prüfen Sie, ob die Zitation formal korrekt ist, bevor Sie sie in einer Arbeit verwenden. Benutzen Sie gegebenenfalls den "Exportieren"-Dialog, wenn Sie ein Literaturverwaltungsprogramm verwenden und die Zitat-Angaben selbst formatieren wollen.

Is cognitive dysfunction involved in difficult-to-treat depression? Characterizing resistance from a cognitive perspective.