[Progress of Immunotherapy Mechanisms and Current Evidence of PD-1/PD-L1 Checkpoint Inhibitors for Non-small Cell Lung Cancer with Brain Metastasis].
In: Zhongguo fei ai za zhi = Chinese journal of lung cancer, Jg. 23 (2020-11-20), Heft 11, S. 976-982
Online
academicJournal
Zugriff:
Brain metastasis (BM) is a common complication in non-small cell lung cancer (NSCLC), which associates with poor prognosis. Recently, immune checkpoint inhibitors (ICIs) has revolutionized the treatment of tumors. Programmed death-1 (PD-1)/programmed death ligand 1 (PD-L1) inhibitors could produce antitumor effect by activating the autoimmune system. The immunotherapy has already show to have a promising outcome for NSCLC patients with BM, while its specific curative effect and the most ideal mode of the treatment remain to be explored. Here we reviewed the tumor microenvironment (TME) in BM lesions and summarized the role of PD-1/PD-L1 inhibitors in cerebral and its current status in clinical studies.
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| Titel: |
[Progress of Immunotherapy Mechanisms and Current Evidence of PD-1/PD-L1
Checkpoint Inhibitors for Non-small Cell Lung Cancer with Brain Metastasis].
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| Autor/in / Beteiligte Person: | Sheng, J ; Yu, X ; Li, H ; Fan, Y |
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| Zeitschrift: | Zhongguo fei ai za zhi = Chinese journal of lung cancer, Jg. 23 (2020-11-20), Heft 11, S. 976-982 |
| Veröffentlichung: | 2008- : Tianjin Shi : Zhongguo fei ai za zhi bian ji wei yuan hui ; <i>Original Publication</i>: Chendu Shi : Zhongguo fei ai za zhi bian ji wei yuan hui, 2020 |
| Medientyp: | academicJournal |
| ISSN: | 1999-6187 (electronic) |
| DOI: | 10.3779/j.issn.1009-3419.2020.102.31 |
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