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Background: Novel coronavirus disease 2019 (COVID-19) is an emerging infectious disease caused by SARS-CoV-2. At the peak of the outbreak in Wuhan (January and February), there are two types of COVID-19 patients: laboratory confirmation and clinical diagnosis. This study aims to compare and analyze the clinical outcomes and characteristics of confirmed and clinically diagnosed COVID-19 patients to determine whether they are of the same type and require equal treatment. More importantly, the prognostic factors of COVID-19 patients are explored.

Methods: A total of 194 hospitalized patients with COVID-19 pneumonia were retrospectively studied. Demographic data, clinical characteristcs, laboratory results and prognostic information were collected by electronic medical record system and analyzed.

Results: Among 194 subjects included, 173 were confirmed and 21 were clinically diagnosed. There were no significant differences in clinical outcomes (mortality rate 39[22.54%] vs 7[33.33%], P=0.272) and hospital stay (19.00 vs 16.90 days, P=0.411) between the confirmed and clinically diagnosed group, and prognostic factors were similar between them. Older age, lower albumin levels, higher serum Lactate dehydrogenase (LDH) levels, higher D-D levels, longer prothrombin time (PT), higher IL-6 levels, lower T cells indicated poor prognosis in patients with COVID-19 pneumonia. NK cell has the highest AUC among all measured indicators (NK AUC=0.926, P<0.001).

Conclusion: Laboratory-confirmed and clinically diagnosed COVID-19 patients are similar in clinical outcomes and most clinical characteristics. They are of the same type and require equal treatment. Age, AST, LDH, BUN, PT, D-D, IL6, white blood cell and neutrophil counts, T cell and T cell subset counts can efficiently predict clinical outcomes.

Titel:	Clinical characteristics of confirmed and clinically diagnosed patients with 2019 novel coronavirus pneumonia: a single-center, retrospective, case-control study.
Autor/in / Beteiligte Person:	Ke, C ; Yu, C ; Yue, D ; Zeng, X ; Hu, Z ; Yang, C
Zeitschrift:	Medicina clinica, Jg. 155 (2020-10-23), Heft 8, S. 327-334
Veröffentlichung:	<2009- > : Madrid : Elsevier España ; <i>Original Publication</i>: Barcelona : Ediciones Doyma, S.A., 2020
Medientyp:	academicJournal
ISSN:	1578-8989 (electronic)
DOI:	10.1016/j.medcli.2020.06.055
Schlagwort:	Adult Aged Biomarkers blood COVID-19 COVID-19 Testing Case-Control Studies China epidemiology Coronavirus Infections blood Coronavirus Infections epidemiology Coronavirus Infections therapy Female Hospitalization Humans Male Middle Aged Pandemics Pneumonia, Viral blood Pneumonia, Viral epidemiology Pneumonia, Viral therapy Predictive Value of Tests Prognosis Retrospective Studies SARS-CoV-2 Betacoronavirus isolation & purification Clinical Laboratory Techniques methods Coronavirus Infections diagnosis Pneumonia, Viral diagnosis
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: English Publication Type: Journal Article; Research Support, Non-U.S. Gov't Language: English; Spanish; Castilian [Med Clin (Barc)] 2020 Oct 23; Vol. 155 (8), pp. 327-334. <i>Date of Electronic Publication: </i>2020 Jul 28. MeSH Terms: Betacoronavirus* / isolation & purification ; Clinical Laboratory Techniques / methods ; Coronavirus Infections / diagnosis ; Pneumonia, Viral / *diagnosis ; Adult ; Aged ; Biomarkers / blood ; COVID-19 ; COVID-19 Testing ; Case-Control Studies ; China / epidemiology ; Coronavirus Infections / blood ; Coronavirus Infections / epidemiology ; Coronavirus Infections / therapy ; Female ; Hospitalization ; Humans ; Male ; Middle Aged ; Pandemics ; Pneumonia, Viral / blood ; Pneumonia, Viral / epidemiology ; Pneumonia, Viral / therapy ; Predictive Value of Tests ; Prognosis ; Retrospective Studies ; SARS-CoV-2 References: N Engl J Med. 2020 Feb 20;382(8):727-733. (PMID: 31978945) ; JAMA. 2020 Mar 17;323(11):1061-1069. (PMID: 32031570) ; Lancet. 2020 Mar 28;395(10229):1054-1062. (PMID: 32171076) ; Clin Infect Dis. 2020 Jul 28;71(15):762-768. (PMID: 32161940) ; Lancet Infect Dis. 2020 Apr;20(4):425-434. (PMID: 32105637) ; Fa Yi Xue Za Zhi. 2020 Feb;36(1):21-23. (PMID: 32198987) ; Semin Immunopathol. 2017 Jul;39(5):529-539. (PMID: 28466096) ; Nat Rev Immunol. 2020 May;20(5):269-270. (PMID: 32273594) ; Lancet. 2020 Feb 15;395(10223):497-506. (PMID: 31986264) ; Radiology. 2020 Aug;296(2):E32-E40. (PMID: 32101510) ; JAMA Intern Med. 2020 Jul 1;180(7):934-943. (PMID: 32167524) ; Lancet. 2020 Feb 15;395(10223):507-513. (PMID: 32007143) ; J Med Virol. 2020 Oct;92(10):2249. (PMID: 32881013) ; Lancet Respir Med. 2020 Apr;8(4):420-422. (PMID: 32085846) ; Int J Antimicrob Agents. 2020 May;55(5):105954. (PMID: 32234467) ; Mediators Inflamm. 2016;2016:8191254. (PMID: 27110067) ; Cell Host Microbe. 2020 Jun 10;27(6):992-1000.e3. (PMID: 32320677) Contributed Indexing: Keywords: COVID-19; Características clínicas; Citocina; Clinical Characteristics; Clinically diagnose; Confirmado; Confirmed; Coronavirus; Cytokine; Diagnóstico clínico; Leucocito; Leucocyte; Prognosis; Pronóstico; SARS-CoV-2 Substance Nomenclature: 0 (Biomarkers) Entry Date(s): Date Created: 20200813 Date Completed: 20201102 Latest Revision: 20231111 Update Code: 20231215 PubMed Central ID: PMC7386390

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Clinical characteristics of confirmed and clinically diagnosed patients with 2019 novel coronavirus pneumonia: a single-center, retrospective, case-control study.