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Group 2 innate lymphoid cells (ILC2s) represent the major player during hyperresponsive airway inflammation. Peroxisome proliferator-activated receptor-γ (PPARγ) was highly expressed on ILC2 and its potential role in asthma has been suggested. However, the detailed mechanism underlying the effects of PPARγ on ILC2-induced airway inflammation remains to be fully understood. Here we identified PPARγ as a positive regulator of lung ILC2. Expression of PPARγ on ILC2 was dramatically induced upon interleukin-33 (IL-33) challenge. Deficiency of PPARγ in hematopoietic system in mice (PPARγ fl/fl Vav1 Cre ) significantly impaired the function of ILC2 in lung, which led to apparent alleviation of airway inflammation in response to IL-33 or Papain challenge, when compared with those in PPARγ fl/fl littermates control. Mechanistic studies identified IL-33 receptor ST2 as a transcriptional target of PPARγ. Overexpression of ST2 rescued the functional defects of ILC2 lacking PPARγ. Collectively, these results demonstrated PPARγ as an important regulator of ILC2 during allergic airway inflammation, which sheds new lights on the importance of PPARγ in asthma.

Titel:	PPARγ enhances ILC2 function during allergic airway inflammation via transcription regulation of ST2.
Autor/in / Beteiligte Person:	Xiao, Q ; He, J ; Lei, A ; Xu, H ; Zhang, L ; Zhou, P ; Jiang, G ; Zhou, J
Link:	Full Text Finder (Volltext)
Zeitschrift:	Mucosal immunology, Jg. 14 (2021-03-01), Heft 2, S. 468-478
Veröffentlichung:	2023- : [New York, NY] : Elsevier ; <i>Original Publication</i>: New York, NY : Nature Pub. Group, c2008-, 2021
Medientyp:	academicJournal
ISSN:	1935-3456 (electronic)
DOI:	10.1038/s41385-020-00339-6
Schlagwort:	Animals Cells, Cultured Cytokines metabolism Gene Expression Regulation Humans Immunity, Innate Interleukin-1 Receptor-Like 1 Protein genetics Mice Mice, Inbred C57BL Mice, Inbred NOD Mice, Knockout PPAR gamma genetics Th2 Cells immunology Asthma immunology Hypersensitivity immunology Inflammation immunology Interleukin-1 Receptor-Like 1 Protein metabolism Lymphocytes immunology PPAR gamma metabolism Respiratory System immunology
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: English Publication Type: Journal Article; Research Support, Non-U.S. Gov't Language: English [Mucosal Immunol] 2021 Mar; Vol. 14 (2), pp. 468-478. <i>Date of Electronic Publication: </i>2020 Aug 18. MeSH Terms: Asthma / immunology ; Hypersensitivity / immunology ; Inflammation / immunology ; Interleukin-1 Receptor-Like 1 Protein / metabolism ; Lymphocytes / immunology ; PPAR gamma / metabolism ; Respiratory System / *immunology ; Animals ; Cells, Cultured ; Cytokines / metabolism ; Gene Expression Regulation ; Humans ; Immunity, Innate ; Interleukin-1 Receptor-Like 1 Protein / genetics ; Mice ; Mice, Inbred C57BL ; Mice, Inbred NOD ; Mice, Knockout ; PPAR gamma / genetics ; Th2 Cells / immunology Comments: Comment in: Mucosal Immunol. 2021 May;14(3):544-546. (PMID: 33328594) References: Papi, A., Brightling, C., Pedersen, S. E. & Reddel, H. K. Asthma. Lancet 391, 783–800 (2018). (PMID: 29273246) ; Lambrecht, B. N. & Hammad, H. 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PPARγ enhances ILC2 function during allergic airway inflammation via transcription regulation of ST2.