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Objective: To evaluate the clinical characteristics and prognosis of gallbladder cancer (GBC) patients in China. Methods: This retrospective multicenter cohort study enrolled 3 528 consecutive GBC patients diagnosed between January 2010 to December 2017 in 15 hospitals from 10 provinces. There were 1 345 (38.12%) males and 2 183 (61.88%) females.The age of diagnosis was (63.7±10.8) years old (range: 26 to 99 years old) .There were 213 patients (6.04%) in stage 0 to Ⅰ, whereas 1 059 (30.02%) in stage Ⅱ to Ⅲ, 1 874 (53.12%) in stage Ⅳ, and 382 (10.83%) unavailable. Surgery was performed on 2 255 patients (63.92%) . Three hundred and thirty-six patients received chemotherapy or radiotherapy (9.52%; of which 172 were palliative); 1 101 (31.21%) received only supportive treatment.The patient source, treatment and surgery, pathology, concomitant gallstone, and prognosis were analyzed. Results: Among the 3 528 GBC patients, 959 (27.18%) were from East China, 603 (17.09%) from East-North China, 1 533 (43.45%) from Central China, and 433(12.27%) from West China. Among the 1 578 resectable tumor, 665 (42.14%) underwent radical surgery, 913 (57.86%) underwent surgery that failed to follow the guidelines.Eight hundred and ninety-one (56.46%) patients were diagnosed before surgery, 254 (16.10%) during surgery, and 381 (24.14%) after surgery (time point of diagnosis couldn't be determined in 52 patients) .Among the 1 578 patients with resectable tumor, 759 (48.10%) had concomitant gallstone.Among the 665 patients underwent radical surgery, 69 (10.4%) showed positive resection margin, 510 (76.7%) showed negative resection margin, and 86 (12.9%) unreported margin status.The 5-year overall survival rate (5yOS) for the 3 528-patient cohort was 23.0%.The 5yOS for patients with resectable tumor was 39.6%, for patients with stage ⅣB tumor without surgery was 5.4%, and for patients with stage ⅣB tumor underwent palliative surgery was 4.7%. Conclusions: More than half GBC patients in China are diagnosed in stage Ⅳ.Curative intent surgery is valuable in improving prognosis of resectable GBC.The treatment of GBC needs further standardization.Effective comprehensive treatment for GBC is in urgent need.

Titel:	[Analysis of treatment modalities and prognosis of patients with gallbladder cancer in China from 2010 to 2017].
Autor/in / Beteiligte Person:	Ren, T ; Li, YS ; Geng, YJ ; Li, ML ; Wu, XS ; Wu, WW ; Wang, XA ; Shu, YJ ; Bao, RF ; Dong, P ; Gong, W ; Gu, J ; Wang, XF ; Lu, JH ; Mu, JS ; Pan, WH ; Zhang, X ; Zhang, XL ; Fei, ZW ; Zhang, ZY ; Wang, Y ; Cao, H ; Sun, B ; Cui, YF ; Zhu, CF ; Li, B ; Zheng, LH ; Qian, YB ; Liu, J ; Dang, XY ; Liu, C ; Peng, SY ; Quan, ZW ; Liu, YB
Zeitschrift:	Zhonghua wai ke za zhi [Chinese journal of surgery], Jg. 58 (2020-09-01), Heft 9, S. 697-706
Veröffentlichung:	Beijing : Zhonghua yi xue hui, Wai ke xue hui, 2020
Medientyp:	academicJournal
ISSN:	0529-5815 (print)
DOI:	10.3760/cma.j.cn112139-20200403-00279
Schlagwort:	Adult Aged Aged, 80 and over China Female Gallbladder Neoplasms pathology Humans Male Middle Aged Neoplasm Staging Prognosis Retrospective Studies Gallbladder Neoplasms therapy
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: Chinese Publication Type: Journal Article Language: Chinese [Zhonghua Wai Ke Za Zhi] 2020 Sep 01; Vol. 58 (9), pp. 697-706. MeSH Terms: Gallbladder Neoplasms / *therapy ; Adult ; Aged ; Aged, 80 and over ; China ; Female ; Gallbladder Neoplasms / pathology ; Humans ; Male ; Middle Aged ; Neoplasm Staging ; Prognosis ; Retrospective Studies Grant Information: 31620103910, 81874181 National Natural Science Foundation of China; 2019ZX09301158 The National Science and Technology Major Projects for "Major New Drugs Innovation and Development"; 2019-RGZN-01096 The Shanghai Artificial Intelligence Innovation and Development Project; SHDC12018107 The Emerging Frontier Program of Hospital Development Center; DLY201507, 15ZH4003 The Multicenter Clinical Research Project of Shanghai Jiao Tong University School of Medicine Contributed Indexing: Keywords: Disease attributes; Gallbladder neoplasms; Prognosis; Surgery ; Local Abstract: [Publisher, Chinese] 目的：探讨我国胆囊癌患者的临床特征和预后情况。方法：多中心回顾性队列研究。回顾性收集中国10个省市15家医院2010年1月至2017年12月收治的3 528例胆囊癌患者资料。男性1 345例（38.12%），女性2 183例（61.88%）；初诊年龄（63.7±10.8）岁（范围：26~99岁）。其中0~Ⅰ期213例（6.04%），Ⅱ~Ⅲ期1 059例（30.02%），Ⅳ期1 874例（53.12%），382例（10.83%）无法判断分期；行手术治疗2 255例（63.92%），行放疗或化疗336例（9.52%，其中172例为姑息性治疗)，仅支持治疗1 101例（31.21%）。总结和分析3 528例胆囊癌患者的地区分布、治疗方式、手术情况、病理学检查结果、合并胆囊结石情况、预后情况。结果：在3 528例诊断为胆囊癌的患者中，959例（27.18%）来自东部地区，603例（17.09%）来自东北地区，1 533例（43.45%）来自中部地区，433例（12.27%）来自西部地区。在1 578例可切除的患者中，759例（48.10%）合并胆囊结石。在1 578例可切除的患者中，665例（42.14%）行根治性切除，913例手术未达根治标准（57.86%）；891例（56.46%）患者在术前得到恶性肿瘤诊断，254例（16.10%）为术中诊断，381例（24.14%）为术后诊断，52例无法判断（3.30%）。在665例根治性切除患者中，切缘阳性69例（10.4%），切缘阴性510例（76.7%），86例（12.9%）切缘情况不详。3 528例胆囊癌患者的5年总体生存率为23.0%，其中可切除肿瘤患者的5年生存率为39.6%，晚期未手术患者为5.4%，姑息性手术患者为4.7%。结论：我国胆囊癌患者初诊超过半数为Ⅳ期；手术切除是提高可切除患者生存期的有效方式。胆囊癌的治疗尚不规范，亟需有效的综合治疗手段。. Entry Date(s): Date Created: 20200904 Date Completed: 20200921 Latest Revision: 20200921 Update Code: 20231215

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[Analysis of treatment modalities and prognosis of patients with gallbladder cancer in China from 2010 to 2017].