Einzeltreffer — DigiBib

Objective: To summarize the application status of hypoxia mimetic agents in bone tissue engineering.

Methods: The related literature about the hypoxia mimetic agents in bone tissue engineering was reviewed and analyzed. And the application status and progress of hypoxia mimetic agents in bone tissue engineering were retrospectively analyzed.

Results: Hypoxia mimetic agents have the same effect as hypoxia in up-regulating the level of hypoxia inducible factor 1α (HIF-1α). The combination of hypoxia mimetic agents and scaffolds can up-regulate the level of HIF-1α in bone tissue engineering, thus promoting early vascularization and bone regeneration of the bone defect area, which provides a new idea for using bone tissue engineering to repair bone defect. At present, the commonly used hypoxia mimetic agents include iron chelating agents, oxoglutarate competitive analogues, proline hydroxylase inhibitors, etc .

Conclusion: Hypoxia mimetic agents have a wide application prospect in bone tissue engineering, but they have been used in bone tissue engineering for a short time, more attention should be paid to their possible side effects. In the future research, the hypoxia mimetic agents should be developed in the direction of higher targeting specificity and safety, and the exact mechanism of hypoxia mimetic agents in promoting bone regeneration should be further explored.

Titel:	[Application status of hypoxia mimetic agents in bone tissue engineering].
Autor/in / Beteiligte Person:	Ren, S ; Liu, Y ; Zhu, Y ; Wang, Y ; Liu, M ; Zhou, Y
Zeitschrift:	Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery, Jg. 34 (2020-09-15), Heft 9, S. 1190-1194
Veröffentlichung:	Chengdu Shi : Hua xi yi ke da xue Fu shu di 1 yi yuan ; <i>Original Publication</i>: Chengdu Shi : Hua xi yi ke da xue Fu shu di 1 yi yuan,, 2020
Medientyp:	academicJournal
ISSN:	1002-1892 (print)
DOI:	10.7507/1002-1892.201911144
Schlagwort:	Bone Regeneration Humans Hypoxia Hypoxia-Inducible Factor 1, alpha Subunit Retrospective Studies Bone and Bones Tissue Engineering
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: Chinese Publication Type: Journal Article Language: Chinese [Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi] 2020 Sep 15; Vol. 34 (9), pp. 1190-1194. MeSH Terms: Bone and Bones* ; Tissue Engineering* ; Bone Regeneration ; Humans ; Hypoxia ; Hypoxia-Inducible Factor 1, alpha Subunit ; Retrospective Studies References: Int J Cardiol. 2013 Oct 3;168(3):2474-80. (PMID: 23590933) ; J Neurotrauma. 2019 Dec 15;36(24):3394-3409. (PMID: 31232175) ; Ann Plast Surg. 2016 Nov;77(5):560-568. (PMID: 26808734) ; Acta Biomater. 2014 Aug;10(8):3641-9. (PMID: 24769115) ; Anticancer Res. 2009 Aug;29(8):3131-8. (PMID: 19661326) ; Int J Biol Sci. 2019 Aug 8;15(10):2156-2169. (PMID: 31592233) ; Biomaterials. 2013 Jan;34(2):422-33. (PMID: 23083929) ; Molecules. 2015 Nov 19;20(11):20551-68. (PMID: 26610437) ; Tissue Eng Part A. 2017 Dec;23(23-24):1372-1381. (PMID: 28562185) ; Sci Rep. 2019 Apr 15;9(1):6035. (PMID: 30988335) ; Nat Rev Rheumatol. 2012 Mar 27;8(6):358-66. (PMID: 22450551) ; Cytotherapy. 2009;11(3):261-7. (PMID: 19308769) ; J Tissue Eng Regen Med. 2007 Nov-Dec;1(6):417-24. (PMID: 18247428) ; J Gene Med. 2016 Apr;18(4-6):57-64. (PMID: 26929250) ; Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi. 2016 Apr;30(4):504-8. (PMID: 27411282) ; Acta Biomater. 2013 Nov;9(11):9159-68. (PMID: 23811216) ; J Control Release. 2018 Jun 10;279:69-78. (PMID: 29649529) ; Biomaterials. 2015 Jun;52:358-66. (PMID: 25818442) ; J Biomater Appl. 2020 Feb;34(7):1028-1037. (PMID: 31648612) ; Sci Rep. 2017 Mar 13;7:44129. (PMID: 28287178) ; ACS Appl Mater Interfaces. 2016 Nov 30;8(47):32450-32459. (PMID: 27809470) ; Adv Healthc Mater. 2016 Jun;5(11):1299-309. (PMID: 26945787) ; Tissue Eng Part A. 2013 Feb;19(3-4):548-57. (PMID: 23298240) ; J Biomed Mater Res A. 2012 Sep;100(9):2392-400. (PMID: 22528604) ; Acta Biomater. 2019 Aug;94:253-267. (PMID: 31154054) ; Clin J Am Soc Nephrol. 2016 Jun 6;11(6):982-91. (PMID: 27094610) ; Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi. 2018 Sep 1;32(9):1150-1156. (PMID: 30129346) ; Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi. 2016 Jul 8;30(7):903-908. (PMID: 29786329) ; Acta Biomater. 2014 Jun;10(6):2834-42. (PMID: 24512978) ; Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi. 2018 Mar 01;32(3):264-269. (PMID: 29806273) ; Stem Cells Int. 2016;2016:9671732. (PMID: 27829841) ; J Vasc Res. 2015;52(3):172-96. (PMID: 26484858) ; Annu Rev Biomed Eng. 2013;15:177-200. (PMID: 23642245) ; Curr Top Med Chem. 2008;8(4):300-10. (PMID: 18393893) ; Free Radic Biol Med. 2004 Dec 15;37(12):1921-42. (PMID: 15544913) ; J Cell Physiol. 2019 Nov;234(11):21182-21192. (PMID: 31032948) ; Tissue Eng Part A. 2013 Aug;19(15-16):1754-63. (PMID: 23469769) ; J Mater Sci Mater Med. 2018 Dec 18;30(1):1. (PMID: 30564959) ; J Biomater Appl. 2018 Jan;32(6):738-753. (PMID: 29295641) ; Biomaterials. 2015 Jun;53:239-50. (PMID: 25890723) ; Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi. 2017 Dec 1;31(12):1462-1467. (PMID: 29806388) ; Oncotarget. 2015 Oct 27;6(33):34158-77. (PMID: 26415222) ; Mater Sci Eng C Mater Biol Appl. 2016 Jan 1;58:648-58. (PMID: 26478356) ; Biomaterials. 2012 Mar;33(7):2076-85. (PMID: 22177618) ; Nanoscale. 2012 Dec 7;4(23):7475-88. (PMID: 23100043) ; Tissue Eng. 2006 Aug;12(8):2093-104. (PMID: 16968151) Contributed Indexing: Keywords: Bone tissue engineering; bone repair; hypoxia mimetic agents; vascularization ; Local Abstract: [Publisher, Chinese] 总结缺氧模拟剂在骨组织工程中的应用现状。. [Publisher, Chinese] 广泛查阅国内外骨组织工程中缺氧模拟剂研究相关文献，对其应用现状进行总结分析。. [Publisher, Chinese] 缺氧模拟剂在上调缺氧诱导因子 1α（hypoxia inducible factor 1α，HIF-1α）水平方面具有与缺氧相同的效果，在骨组织工程研究中，将其与支架材料结合后可以促进缺损部位的早期血管化和骨形成，为利用组织工程骨修复骨缺损提供了新思路。目前研究常用的缺氧模拟剂包括铁螯合剂、氧化戊二酸竞争类似物、新型脯氨酸羟化酶抑制剂等。. [Publisher, Chinese] 缺氧模拟剂在骨组织工程中具有广泛应用前景，但用于骨组织工程时间较短，需要重点关注其可能产生的副作用。下一步研究应朝着使缺氧模拟剂靶向特异性及安全性更高的方向发展，并进一步探索其促进骨再生的确切机制。. Substance Nomenclature: 0 (Hypoxia-Inducible Factor 1, alpha Subunit) Entry Date(s): Date Created: 20200915 Date Completed: 20200916 Latest Revision: 20220416 Update Code: 20240513 PubMed Central ID: PMC8171726

Klicken Sie ein Format an und speichern Sie dann die Daten oder geben Sie eine Empfänger-Adresse ein und lassen Sie sich per Email zusenden.

BibTeX Citavi, JabRef, u.a.
(Literaturverwaltung)

PDF kein Volltext!
(Merkzettel, Notizen)

RIS Endnote, Citavi u.a.
(Literaturverwaltung)

MODS
(XML zur Weiterverarbeitung)

oder

Wählen Sie das für Sie passende Zitationsformat und kopieren Sie es dann in die Zwischenablage, lassen es sich per Mail zusenden oder speichern es als PDF-Datei.

Gewünschter Zitations-Stil:

oder

Bitte prüfen Sie, ob die Zitation formal korrekt ist, bevor Sie sie in einer Arbeit verwenden. Benutzen Sie gegebenenfalls den "Exportieren"-Dialog, wenn Sie ein Literaturverwaltungsprogramm verwenden und die Zitat-Angaben selbst formatieren wollen.

[Application status of hypoxia mimetic agents in bone tissue engineering].