Accurate Noninvasive Assessment of Myocardial Iron Load in Advanced Heart Failure Patients.
In: Disease markers, Jg. 2020 (2020-11-07), S. 8885189
Online
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Zugriff:
Background: Heart failure patients presenting with iron deficiency can benefit from systemic iron supplementation; however, there is the potential for iron overload to occur, which can seriously damage the heart. Therefore, myocardial iron (M-Iron) content should be precisely balanced, especially in already failing hearts. Unfortunately, the assessment of M-Iron via repeated heart biopsies or magnetic resonance imaging is unrealistic, and alternative serum markers must be found. This study is aimed at assessing M-Iron in patients with advanced heart failure (HF) and its association with a range of serum markers of iron metabolism.
Methods: Left ventricle (LV) myocardial biopsies and serum samples were collected from 33 consecutive HF patients (25 males) with LV dysfunction (LV ejection fraction 22 (11) %; NT-proBNP 5464 (3308) pg/ml) during heart transplantation. Myocardial ferritin (M-FR) and soluble transferrin receptor (M-sTfR1) were assessed by ELISA, and M-Iron was determined by Instrumental Neutron Activation Analysis in LV biopsies. Nonfailing hearts ( n = 11) were used as control/reference tissue. Concentrations of serum iron-related proteins (FR and sTfR1) were assessed.
Results: LV M-Iron load was reduced in all HF patients and negatively associated with M-FR ( r = -0.37, p = 0.05). Of the serum markers, sTfR1/logFR correlated with ( r = -0.42; p = 0.04) and predicted (in a step-wise analysis, R 2 = 0.18; p = 0.04) LV M-Iron. LV M-Iron load ( μ g/g) can be calculated using the following formula: 210.24-22.869 × sTfR1/logFR.
Conclusions: The sTfR1/logFR ratio can be used to predict LV M-Iron levels. Therefore, serum FR and sTfR1 levels could be used to indirectly assess LV M-Iron, thereby increasing the safety of iron repletion therapy in HF patients.
Competing Interests: There are no potential conflicts of interest, including related consultancies, shareholdings, and funding grants.
(Copyright © 2020 Przemysław Leszek et al.)
| Titel: |
Accurate Noninvasive Assessment of Myocardial Iron Load in Advanced Heart Failure Patients.
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| Autor/in / Beteiligte Person: | Leszek, P ; Sochanowicz, B ; Brzóska, K ; Kraj, L ; Kuśmierczyk, M ; Śmigielski, W ; Rywik, TM ; Sobieszczańska-Małek, M ; Rozentryt, P ; Kruszewski, M |
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| Zeitschrift: | Disease markers, Jg. 2020 (2020-11-07), S. 8885189 |
| Veröffentlichung: | 2015- : New York, NY : Hindawi Pub. Corp. ; <i>Original Publication</i>: Chichester ; New York : Wiley, c1983-, 2020 |
| Medientyp: | academicJournal |
| ISSN: | 1875-8630 (electronic) |
| DOI: | 10.1155/2020/8885189 |
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