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Intracranial aneurysm (IA) is a complex disease caused by genetic and environmental factors. Evidence indicates that inflammation plays an important role in IA occurrence. We aimed to explore the associations between inflammatory cytokine gene polymorphisms and IA in a Chinese population. This study enrolled 768 participants of Han ethnicity, including 384 patients with IA and 384 healthy individuals. Sixteen single nucleotide polymorphisms (SNPs) of IL1 , IL6 , IL12 , and TNF-α genes were genotyped using the Sequenom MassARRAY platform. Univariate and multivariate logistic regression analyses were used to analyze the associations. We found IL12B rs3181216 was significantly associated with IA in the recessive and additive models (OR = 0.46, 95% CI = 0.23-0.89, P = 0.022; OR = 0.74, 95% CI = 0.56-0.98, P = 0.034, respectively). TNF-α rs1799964 was associated with IA in dominant and additive models (OR = 0.67, 95% CI = 0.46-0.98, P = 0.041; OR = 0.71, 95% CI = 0.51-0.98, P = 0.034, respectively). IL1A rs17561 was associated with single IA susceptibility (dominant model: OR = 0.52, 95% CI = 0.31-0.85, P = 0.040). The IL12B rs3181216 polymorphism was associated with single IA susceptibility in the recessive model (OR = 0.41, 95% CI = 0.18-0.93, P = 0.033). The IL12B rs2195940 polymorphism was associated with multiple IAs susceptibility (dominant model: OR = 0.28, 95% CI = 0.09-0.89, P = 0.031; additive model: OR = 0.28, 95% CI = 0.09-0.90, P = 0.032). TNF-α rs1799964 was associated with multiple IAs susceptibility in the dominant model (OR = 0.54, 95% CI = 0.30-0.97, P = 0.040). No associations were found between other polymorphisms and IA susceptibility. Therefore, IL1A , IL12B , and TNF-α gene polymorphisms are associated with IA susceptibility in a Chinese population.

Competing Interests: The authors declare that there is no conflict of interest regarding the publication of this study.

Titel:	Associations between Inflammatory Cytokine Gene Polymorphisms and Susceptibilities to Intracranial Aneurysm in Chinese Population.
Autor/in / Beteiligte Person:	Xu, L ; Hu, L ; Hu, C ; Liu, J ; Li, B ; Liao, X ; Zhou, J ; Liu, S ; Li, Y ; Yuan, D ; Jiang, W ; Yan, J
Link:	Full Text Finder (Volltext)
Zeitschrift:	BioMed research international, Jg. 2021 (2021-01-16), S. 8865601
Veröffentlichung:	New York, NY : Hindawi Pub. Co., 2021
Medientyp:	academicJournal
ISSN:	2314-6141 (electronic)
DOI:	10.1155/2021/8865601
Schlagwort:	Aged Asian People genetics Case-Control Studies Female Genetic Predisposition to Disease Humans Interleukin-12 Subunit p40 genetics Interleukin-1alpha genetics Interleukin-6 genetics Linkage Disequilibrium Male Middle Aged Tumor Necrosis Factor-alpha genetics Cytokines genetics Inflammation genetics Intracranial Aneurysm genetics Polymorphism, Single Nucleotide
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: English Publication Type: Journal Article Language: English [Biomed Res Int] 2021 Jan 16; Vol. 2021, pp. 8865601. <i>Date of Electronic Publication: </i>2021 Jan 16 (<i>Print Publication: </i>2021). MeSH Terms: Polymorphism, Single Nucleotide* ; Cytokines / genetics ; Inflammation / genetics ; Intracranial Aneurysm / *genetics ; Aged ; Asian People / genetics ; Case-Control Studies ; Female ; Genetic Predisposition to Disease ; Humans ; Interleukin-12 Subunit p40 / genetics ; Interleukin-1alpha / genetics ; Interleukin-6 / genetics ; Linkage Disequilibrium ; Male ; Middle Aged ; Tumor Necrosis Factor-alpha / genetics References: Stroke. 2014 Aug;45(8):2239-45. (PMID: 24938844) ; Crit Care Med. 2005 Dec;33(12 Suppl):S463-5. (PMID: 16340422) ; Arterioscler Thromb Vasc Biol. 2018 Apr;38(4):843-853. (PMID: 29472233) ; J Neurol Neurosurg Psychiatry. 2006 Aug;77(8):915-7. (PMID: 16648144) ; J Neurol Sci. 2011 Jul 15;306(1-2):94-7. (PMID: 21497830) ; Mol Biol Rep. 2012 Dec;39(12):11217-23. (PMID: 23065210) ; J Neuroinflammation. 2015 Jul 22;12:135. (PMID: 26198819) ; Stroke. 2011 Jan;42(1):173-8. (PMID: 21106959) ; Genet Test Mol Biomarkers. 2012 Jul;16(7):822-6. (PMID: 22686131) ; Acta Neuropathol. 2012 Jun;123(6):773-86. (PMID: 22249619) ; Inflamm Res. 2013 Jul;62(7):641-51. (PMID: 23685857) ; J Mol Neurosci. 2018 Sep;66(1):135-145. (PMID: 30121816) ; Neurosurgery. 2005 Sep;57(3):558-64; discussion 558-64. (PMID: 16145536) ; AJNR Am J Neuroradiol. 2017 Jan;38(1):119-126. (PMID: 27686488) ; Rev Neurol (Paris). 2017 Nov;173(9):542-551. (PMID: 28583271) ; Neurosurgery. 2010 Jun;66(6):1058-62; discussion 1062-3. (PMID: 20495422) ; J Dermatol Sci. 2014 Sep;75(3):167-72. (PMID: 24957500) ; Stroke. 2018 Mar;49(3):780-787. (PMID: 29437983) ; Transl Stroke Res. 2014 Apr;5(2):269-77. (PMID: 24323710) ; Acta Neuropathol Commun. 2014 Mar 31;2:34. (PMID: 24685329) ; Trends Neurosci. 2000 Dec;23(12):618-25. (PMID: 11137152) ; Lancet. 2007 Jan 27;369(9558):306-18. (PMID: 17258671) ; J Mol Neurosci. 2017 Dec;63(3-4):349-354. (PMID: 29027627) ; Circulation. 2009 Apr 28;119(16):2202-8. (PMID: 19364978) ; Hum Immunol. 2013 Dec;74(12):1679-83. (PMID: 23993981) ; Lab Invest. 1989 Dec;61(6):588-602. (PMID: 2481148) ; BMC Neurol. 2017 Dec 11;17(1):214. (PMID: 29228923) ; Microbes Infect. 2001 Feb;3(2):121-9. (PMID: 11251298) ; Trends Cell Biol. 2001 Sep;11(9):372-7. (PMID: 11514191) ; Neurosci Lett. 2008 Jul 25;440(1):1-3. (PMID: 18487018) ; Cancer Immunol Immunother. 2014 May;63(5):419-35. (PMID: 24514955) ; Surg Neurol Int. 2018 Jul 26;9:150. (PMID: 30105144) ; J Neurol Neurosurg Psychiatry. 2006 Feb;77(2):279-80. (PMID: 16421145) ; Acta Neurol Scand. 2012 Feb;125(2):111-5. (PMID: 21410438) ; Yonsei Med J. 2019 Jul;60(7):651-658. (PMID: 31250579) ; Eur J Radiol. 2013 Oct;82(10):1598-605. (PMID: 23399038) ; J Neuroinflammation. 2014 Apr 16;11:77. (PMID: 24739142) ; J Dermatol Sci. 2002 Nov;30(2):161-6. (PMID: 12413772) ; Arthritis Rheum. 2004 Jun;50(6):1976-83. (PMID: 15188375) Substance Nomenclature: 0 (Cytokines) ; 0 (IL12B protein, human) ; 0 (IL1A protein, human) ; 0 (IL6 protein, human) ; 0 (Interleukin-12 Subunit p40) ; 0 (Interleukin-1alpha) ; 0 (Interleukin-6) ; 0 (TNF protein, human) ; 0 (Tumor Necrosis Factor-alpha) Entry Date(s): Date Created: 20210129 Date Completed: 20210607 Latest Revision: 20221207 Update Code: 20231215 PubMed Central ID: PMC7826207

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Associations between Inflammatory Cytokine Gene Polymorphisms and Susceptibilities to Intracranial Aneurysm in Chinese Population.