Usefulness of staging chest-CT in patients with operable breast cancer.
In: PloS one, Jg. 16 (2021-02-11), Heft 2, S. e0246563
Online
academicJournal
Zugriff:
Objective: The aim of this study was to investigate the usefulness of staging chest-CT in terms of diagnostic yield and false-referral rate in patients with operable breast cancer.
Materials and Methods: This study was approved by the institutional review border. In this retrospective study, we reviewed patients who underwent staging chest-CT between January 2014 and June 2016. Reference standard was defined as a combination of pathology and radiologic tumor changes in accordance with primary tumor or metastatic lesions and stability during the 12-month follow-up period. We calculated diagnostic yield and false-referral rates stratified by pathologic stage. The important ancillary findings of staging chest-CT were also recorded.
Results: A total of 1,342 patients were included in this study. Of these, four patients (0.3%; 4/1342) had true pulmonary metastasis. Diagnostic yields of stage I, II, III disease were 0.0% (0/521), 0.3% (2/693), and 1.6% (2/128), respectively. The overall false-referral rate was 4.6% (62/1342); false-referral rates of stage I, II, and III disease were 5.0% (26/521), 3.8% (26/693), and 7.8% (10/128), respectively. No occult thoracic metastasis occurred within 12 months of staging chest-CT. Nineteen patients showed significant ancillary findings besides lung metastasis, including primary lung cancer (n = 9). The overall diagnostic yield of ancillary findings was 1.7% (23 of 1342).
Conclusions: The incidence of pulmonary metastasis was near zero for pathologic stages I/II and slightly higher (although still low; 1.6%). for stage III. Considering its low diagnostic yield and substantial false-referral rates, staging chest-CT might not be useful in patients with operable breast cancer.
Competing Interests: The authors have declared that no competing interests exist.
Titel: |
Usefulness of staging chest-CT in patients with operable breast cancer.
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Autor/in / Beteiligte Person: | Hong, JH ; Goo, JM ; Moon, HG ; Chang, JM ; Lee, JH ; Park, CM |
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Zeitschrift: | PloS one, Jg. 16 (2021-02-11), Heft 2, S. e0246563 |
Veröffentlichung: | San Francisco, CA : Public Library of Science, 2021 |
Medientyp: | academicJournal |
ISSN: | 1932-6203 (electronic) |
DOI: | 10.1371/journal.pone.0246563 |
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