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Background: Osteoarthritis (OA) is thought to be the most prevalent chronic joint disease, especially in Tibet of China. Here, we aimed to explore the integrative lncRNA and mRNA landscape between the OA patients of Tibet and Han.

Methods: The lncRNA and mRNA expression microarray profiling was performed by SurePrint G3 Human Gene Expression 8x60K v2 Microarray in articular cartilage samples from OA patients of Han nationality and Tibetans, followed by GO, KEGG, and trans-regulation and cis-regulation analysis of lncRNA and mRNA.

Results: We found a total of 117 lncRNAs and 297 mRNAs differently expressed in the cartilage tissues of Tibetans (n = 5) comparing with those of Chinese Han (n = 3), in which 49 lncRNAs and 158 mRNAs were upregulated, and 68 lncRNAs and 139 mRNAs were downregulated. GO and KEGG analysis showed that several unreported biological processes and signaling pathways were particularly identified. LncRNA-mRNA co-expression analysis revealed a remarkable lncRNA-mRNA relationship, in which OTOA may play a critical role in the different mechanisms of the OA progression between Tibetans and Chinese Han.

Conclusion: This study identified different lncRNA/mRNA expression profiling between OA patients of Tibetans and Han, which were involved in many characteristic biological processes and signaling pathways.

Titel:	Comprehensive analysis of lncRNA and mRNA based on expression microarray profiling reveals different characteristics of osteoarthritis between Tibetan and Han patients.
Autor/in / Beteiligte Person:	Luo, J ; Luo, X ; Duan, Z ; Bai, W ; Che, X ; Shan, Z ; Li, X ; Peng, J
Link:	Full Text Finder (Volltext)
Zeitschrift:	Journal of orthopaedic surgery and research, Jg. 16 (2021-02-12), Heft 1, S. 133
Veröffentlichung:	London : BioMed Central, 2006-, 2021
Medientyp:	academicJournal
ISSN:	1749-799X (electronic)
DOI:	10.1186/s13018-021-02213-y
Schlagwort:	Asian People genetics Cartilage, Articular metabolism China Humans Tibet Gene Expression genetics Gene Expression Profiling methods Genetics, Population Osteoarthritis genetics RNA, Long Noncoding genetics RNA, Long Noncoding metabolism RNA, Messenger genetics RNA, Messenger metabolism Tissue Array Analysis methods
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: English Publication Type: Journal Article Language: English [J Orthop Surg Res] 2021 Feb 12; Vol. 16 (1), pp. 133. <i>Date of Electronic Publication: </i>2021 Feb 12. MeSH Terms: Genetics, Population* ; Gene Expression / genetics ; Gene Expression Profiling / methods ; Osteoarthritis / genetics ; RNA, Long Noncoding / genetics ; RNA, Long Noncoding / metabolism ; RNA, Messenger / genetics ; RNA, Messenger / metabolism ; Tissue Array Analysis / methods ; Asian People / genetics ; Cartilage, Articular / metabolism ; China ; Humans ; Tibet References: Invest New Drugs. 2018 Apr;36(2):187-194. (PMID: 29082457) ; Int Orthop. 2001;25(3):191-3. (PMID: 11482539) ; J Cell Physiol. 2019 Aug;234(8):12309-12324. (PMID: 30659623) ; Lancet. 2018 May 19;391(10134):1985. (PMID: 29864015) ; Osteoarthritis Cartilage. 2019 Mar;27(3):371-377. (PMID: 30808485) ; Curr Opin Genet Dev. 2017 Oct;46:170-178. (PMID: 28843809) ; N Engl J Med. 1998 Oct 15;339(16):1112-20. (PMID: 9770558) ; Ann Rheum Dis. 2020 May;79(5):646-656. (PMID: 32205337) ; Osteoarthritis Cartilage. 2015 Apr;23(4):601-6. (PMID: 25596323) ; Br Med Bull. 2019 Jun 19;130(1):137-147. (PMID: 31066454) ; FASEB J. 2020 May;34(5):6466-6478. (PMID: 32175635) ; Osteoarthritis Cartilage. 2018 Mar;26(3):312-318. (PMID: 29107060) ; Joint Bone Spine. 2017 Oct;84(5):553-556. (PMID: 27919571) ; Acta Med Port. 2015 Jan-Feb;28(1):99-106. (PMID: 25817486) ; Osteoarthritis Cartilage. 2015 Apr;23(4):571-80. (PMID: 25575966) ; Expert Rev Mol Diagn. 2018 Jan;18(1):55-74. (PMID: 29235389) ; Eur Rev Med Pharmacol Sci. 2014 Oct;18(20):3056-62. (PMID: 25392105) ; Neuro Oncol. 2019 Nov 4;21(11):1436-1446. (PMID: 31276594) ; Arch Toxicol. 2018 Jul;92(7):2217-2225. (PMID: 29785637) ; BMC Genomics. 2018 Oct 11;19(1):735. (PMID: 30305026) ; Osteoarthritis Cartilage. 2018 Mar;26(3):296-303. (PMID: 29061493) ; Lancet. 1997 Oct 11;350(9084):1074. (PMID: 10213552) ; Chemosphere. 2019 Feb;216:396-403. (PMID: 30384309) ; Int Orthop. 2011 May;35(5):767-76. (PMID: 20544197) ; Int J Mol Med. 2019 Aug;44(2):617-629. (PMID: 31173158) ; Am J Clin Nutr. 2003 Jul;78(1):137-44. (PMID: 12816783) ; Gene. 2018 Mar 20;647:164-173. (PMID: 29331478) ; Front Microbiol. 2018 Jun 27;9:1409. (PMID: 30013528) ; Neuroreport. 2018 Dec 12;29(18):1578-1585. (PMID: 30371540) ; Int Orthop. 2009 Aug;33(4):1085-8. (PMID: 19301003) ; Ann Rheum Dis. 2017 Oct;76(10):1764-1773. (PMID: 28705915) ; Med Sci Monit. 2019 Mar 20;25:2058-2065. (PMID: 30890688) ; Curr Gene Ther. 2019;19(4):255-263. (PMID: 31333128) ; J Cell Physiol. 2019 Aug;234(10):17433-17443. (PMID: 30820958) ; Arthritis Rheumatol. 2016 Nov;68(11):2575-2583. (PMID: 27214788) ; Cell Biosci. 2017 Dec 13;7:69. (PMID: 29255591) ; Analyst. 2016 Feb 7;141(3):740-55. (PMID: 26583164) ; Ann Rheum Dis. 2015 Jun;74(6):1145-9. (PMID: 25416720) ; Biol Trace Elem Res. 2013 Jun;153(1-3):1-4. (PMID: 23649369) ; Lancet. 2011 Jun 18;377(9783):2115-26. (PMID: 21684382) ; World J Pediatr. 2012 May;8(2):140-4. (PMID: 22573424) ; Cell Biosci. 2019 Jul 1;9:54. (PMID: 31304004) ; Biol Trace Elem Res. 2017 Nov;180(1):15-22. (PMID: 28283952) ; Am J Transl Res. 2017 Nov 15;9(11):4747-4755. (PMID: 29218077) ; Cell. 2018 Jan 25;172(3):393-407. (PMID: 29373828) ; J Diabetes Complications. 2017 Mar;31(3):569-576. (PMID: 28007334) ; Bone Joint Res. 2018 May 5;7(4):298-307. (PMID: 29922448) ; Cell Prolif. 2017 Feb;50(1):. (PMID: 27859817) ; Int Orthop. 2001;25(3):164-6. (PMID: 11482533) ; Osteoarthritis Cartilage. 2012 Sep;20(9):1029-38. (PMID: 22659600) ; Bone. 2018 Nov;116:67-77. (PMID: 30010080) ; Cell Biochem Funct. 2020 Jun;38(4):460-471. (PMID: 31960487) ; BMJ. 2011 Nov 24;343:d7122. (PMID: 22115902) ; BMC Med Genet. 2017 Jun 26;18(1):69. (PMID: 28651521) ; J Cell Biochem. 2019 Sep;120(9):16019-16024. (PMID: 31069838) ; Science. 2017 Jan 6;355(6320):. (PMID: 27980086) ; DNA Cell Biol. 2019 Aug;38(8):796-807. (PMID: 31295012) ; Genome Biol. 2014 Dec 03;15(12):523. (PMID: 25633159) ; Int J Mol Sci. 2016 Jul 14;17(7):. (PMID: 27428952) ; J Cell Biochem. 2019 Mar;120(3):4620-4633. (PMID: 30302799) ; Gene. 2019 Feb 15;685:55-61. (PMID: 30393192) Grant Information: 81460022 Chinese Natural Scientific Grant; 81760396 Chinese Natural Scientific Grant; 2016-ZJ-747 Qinghai Natural Scientific Grant; S2017SFYLJS0070 Hunan Provincial Innovation Fund Contributed Indexing: Keywords: Microarray profiling; OTOA; Osteoarthritis; Tibetan; lncRNA-mRNA Substance Nomenclature: 0 (RNA, Long Noncoding) ; 0 (RNA, Messenger) Entry Date(s): Date Created: 20210213 Date Completed: 20210804 Latest Revision: 20221207 Update Code: 20240513 PubMed Central ID: PMC7879695

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Comprehensive analysis of lncRNA and mRNA based on expression microarray profiling reveals different characteristics of osteoarthritis between Tibetan and Han patients.