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Propofol and dexmedetomidine are popular used for sedation in ICU, however, inadequate attention has been paid to their effect on gastrointestinal tract (GIT) motility. Present study aimed to compare the effect of propofol and dexmedetomidine on GIT motility at parallel level of sedation and explore the possible mechanism. Male C57BL/6 mice (8-10 weeks) were randomly divided into control, propofol and dexmedetomidine group. After intraperitoneal injection of propofol or dexmedetomidine, comparable sedative level was confirmed by sedative score, physiological parameters and electroencephalogram (EEG). Different segments of GIT motility in vivo (gastric emptying, small intestine transit, distal colon bead expulsion, stool weight and number of fecal pellets, gastrointestinal transit and whole gut transit time) and colonic migrating motor complexes (CMMCs) pattern in vitro were evaluated. The Ca 2+ response of primary enteric glia was examined under the treatment of propofol or dexmedetomidine. There is little difference in physiological parameters and composite permutation entropy index (CPEI) between administration of 50 mg/kg propofol and 40 μg/kg dexmedetomidine, indicated that parallel level of sedation was reached. Data showed that propofol and dexmedetomidine had significantly inhibitory effect on GIT motility while dexmedetomidine was stronger. Also, the amplitude (ΔF/F0) of Ca 2+ response in primary enteric glia was attenuated after treated with the sedatives while the effect of dexmedetomidine was greater than propofol. These findings demonstrated that dexmedetomidine caused stronger inhibitory effects on GIT motility in sedative mice, which may involve impaired Ca 2+ response in enteric glia. Hence, dexmedetomidine should be carefully applied especially for potential GIT dysmotility patient.

Titel:	Inhibitory Effects of Dexmedetomidine and Propofol on Gastrointestinal Tract Motility Involving Impaired Enteric Glia Ca <superscript>2+</superscript> Response in Mice.
Autor/in / Beteiligte Person:	Li, Y ; Wang, Y ; Chang, H ; Cheng, B ; Miao, J ; Li, S ; Hu, H ; Huang, L ; Wang, Q
Link:	Full Text Finder (Volltext)
Zeitschrift:	Neurochemical research, Jg. 46 (2021-06-01), Heft 6, S. 1410-1422
Veröffentlichung:	1999- : New York, NY : Kluwer Academic/Plenum Publishers ; <i>Original Publication</i>: New York, Plenum Press, 2021
Medientyp:	academicJournal
ISSN:	1573-6903 (electronic)
DOI:	10.1007/s11064-021-03280-7
Schlagwort:	Animals Cells, Cultured Colon drug effects Defecation drug effects Gastric Emptying drug effects Gastrointestinal Transit drug effects Intestine, Small cytology Intestine, Small drug effects Male Mice, Inbred C57BL Mice Calcium metabolism Dexmedetomidine pharmacology Gastrointestinal Motility drug effects Hypnotics and Sedatives pharmacology Neuroglia drug effects Propofol pharmacology
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: English Publication Type: Journal Article Language: English [Neurochem Res] 2021 Jun; Vol. 46 (6), pp. 1410-1422. <i>Date of Electronic Publication: </i>2021 Mar 03. MeSH Terms: Calcium / metabolism ; Dexmedetomidine / pharmacology ; Gastrointestinal Motility / drug effects ; Hypnotics and Sedatives / pharmacology ; Neuroglia / drug effects ; Propofol / pharmacology ; Animals ; Cells, Cultured ; Colon / drug effects ; Defecation / drug effects ; Gastric Emptying / drug effects ; Gastrointestinal Transit / drug effects ; Intestine, Small / cytology ; Intestine, Small / drug effects ; Male ; Mice, Inbred C57BL ; Mice References: Jerath A, Ferguson ND, Steel A, Wijeysundera D, Macdonald J, Wasowicz M (2015) The use of volatile anesthetic agents for long-term critical care sedation (VALTS): study protocol for a pilot randomized controlled trial. Trials 16:560. https://doi.org/10.1186/s13063-015-1083-5. 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Glia 65(5):699–711. https://doi.org/10.1002/glia.23121. (PMID: 10.1002/glia.23121281687325357187) Contributed Indexing: Keywords: Ca2+ response; Dexmedetomidine; Enteric glia; Gastrointestinal tract motility; Propofol Substance Nomenclature: 0 (Hypnotics and Sedatives) ; 67VB76HONO (Dexmedetomidine) ; SY7Q814VUP (Calcium) ; YI7VU623SF (Propofol) Entry Date(s): Date Created: 20210303 Date Completed: 20211012 Latest Revision: 20240226 Update Code: 20240226

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Inhibitory Effects of Dexmedetomidine and Propofol on Gastrointestinal Tract Motility Involving Impaired Enteric Glia Ca <superscript>2+</superscript> Response in Mice.