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Background: Prostate cancer (PC) is one of the most common cancers in men. Although the overall prognosis is favorable, the management of metastatic castration-resistant prostate cancer (mCRPC) patients is challenging. Usually, mCRPC patients with progressive disease are considered for radioligand therapy (RLT) after exhaustion of other standard treatments. The prostate-specific membrane antigen (PSMA) labeled with Lutetium-177 ([ 177 Lu]Lu-PSMA) has been widely used, showing favorable and successful results in reducing prostate-specific antigen (PSA) levels, increasing quality of life, and decreasing pain, in a multitude of studies. Nevertheless, approximately thirty percent of patients do not respond to [ 177 Lu]Lu-PSMA RLT. Here, we only reviewed and reported the evaluated factors and their impact on survival or biochemical response to treatment to have an overview of the potentialprognostic parameters in [ 177 Lu]Lu-PSMA RLT.

Methods: Studies were retrieved by searching MEDLINE/PubMed and GoogleScholar. The search keywords were as follows: {("177Lu-PSMA") AND ("radioligand") AND ("prognosis") OR ("predict")}. Studies discussing one or more factors which may be prognostic or predictive of response to [ 177 Lu]Lu-PSMA RLT, that is PSA response and survival parameters, were included.

Results: Several demographic, histological, biochemical, and imaging factors have been assessed as predictive parameters for the response to thistreatment; however, the evaluated factors were diverse, and the results mostly were divergent, except for the PSA level reduction after treatment, which unanimously predicted prolonged survival.

Conclusion: Several studies have investigated a multitude of factors to detect those predicting response to [ 177 Lu]Lu-PSMA RLT. The results wereinconsistent regarding some factors, and some were evaluated in only a few studies. Future prospective randomized trials are required to detect theindependent prognostic factors, and to further determine the clinical and survival benefits of [ 177 Lu]Lu-PSMA RLT.

Titel:	Factors predicting biochemical response and survival benefits following radioligand therapy with [ <superscript>177</superscript> Lu]Lu-PSMA in metastatic castrate-resistant prostate cancer: a review.
Autor/in / Beteiligte Person:	Manafi-Farid, R ; Harsini, S ; Saidi, B ; Ahmadzadehfar, H ; Herrmann, K ; Briganti, A ; Walz, J ; Beheshti, M
Link:	Full Text Finder (Volltext)
Zeitschrift:	European journal of nuclear medicine and molecular imaging, Jg. 48 (2021-11-01), Heft 12, S. 4028-4041
Veröffentlichung:	Berlin : Springer-Verlag Berlin, 2002-, 2021
Medientyp:	academicJournal
ISSN:	1619-7089 (electronic)
DOI:	10.1007/s00259-021-05237-y
Schlagwort:	Dipeptides Heterocyclic Compounds, 1-Ring Humans Male Prognosis Treatment Outcome Prostatic Neoplasms, Castration-Resistant radiotherapy Quality of Life
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: English Publication Type: Journal Article; Review Language: English [Eur J Nucl Med Mol Imaging] 2021 Nov; Vol. 48 (12), pp. 4028-4041. <i>Date of Electronic Publication: </i>2021 Mar 06. MeSH Terms: Prostatic Neoplasms, Castration-Resistant* / radiotherapy ; Quality of Life* ; Dipeptides ; Heterocyclic Compounds, 1-Ring ; Humans ; Male ; Prognosis ; Treatment Outcome References: Beheshti M, Manafi-Farid R, Geinitz H, Vali R, Loidl W, Mottaghy FM, et al. Multiphasic (68)Ga-PSMA PET/CT in the detection of early recurrence in prostate cancer patients with a PSA level of less than 1 ng/mL: a prospective study of 135 patients. J Nucl Med. 2020;61:1484–90. https://doi.org/10.2967/jnumed.119.238071 . (PMID: 10.2967/jnumed.119.23807132060214) ; National Cancer Institute. Surveillance E, and End Results Program. Cancer Stat Facts: Prostate Cancer. 2010–2016. Available from: https://seer.cancer.gov/statfacts/html/prost.html . 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(PMID: 10.2967/jnumed.118.20927029653975) Contributed Indexing: Keywords: Predictive factors; Prognosis; Radioligand therapy; Response to therapy; [177Lu]Lu-PSMA Substance Nomenclature: 0 (Dipeptides) ; 0 (Heterocyclic Compounds, 1-Ring) Entry Date(s): Date Created: 20210307 Date Completed: 20211019 Latest Revision: 20220315 Update Code: 20231215 PubMed Central ID: PMC8484081

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Factors predicting biochemical response and survival benefits following radioligand therapy with [ <superscript>177</superscript> Lu]Lu-PSMA in metastatic castrate-resistant prostate cancer: a review.