Sonstiges: |
- Nachgewiesen in: MEDLINE
- Sprachen: English
- Publication Type: Journal Article; Research Support, Non-U.S. Gov't
- Language: English
- [Angiogenesis] 2021 Aug; Vol. 24 (3), pp. 471-482. <i>Date of Electronic Publication: </i>2021 Mar 17.
- MeSH Terms: Apoptosis* ; Carcinoma, Lewis Lung* / enzymology ; Carcinoma, Lewis Lung* / genetics ; Focal Adhesion Kinase 1* / genetics ; Focal Adhesion Kinase 1* / metabolism ; Mutation, Missense* ; Neoplasm Proteins* / genetics ; Neoplasm Proteins* / metabolism ; Neovascularization, Pathologic* / enzymology ; Neovascularization, Pathologic* / genetics ; Pericytes / *enzymology ; Amino Acid Substitution ; Animals ; Mice ; Mice, Transgenic ; Phosphorylation
- Comments: Erratum in: Angiogenesis. 2021 Jul 4;:. (PMID: 34218398)
- References: Armulik A, Genove G, Betsholtz C (2011) Pericytes: developmental, physiological, and pathological perspectives, problems, and promises. Dev Cell 21(2):193–215. (PMID: 10.1016/j.devcel.2011.07.00121839917) ; Bergers G, Song S (2005) The role of pericytes in blood-vessel formation and maintenance. Neuro Oncol 7(4):452–464. (PMID: 16212810187172710.1215/S1152851705000232) ; Geevarghese A, Herman IM (2014) Pericyte-endothelial crosstalk: implications and opportunities for advanced cellular therapies. Transl Res 163(4):296–306. (PMID: 24530608397671810.1016/j.trsl.2014.01.011) ; von Tell D, Armulik A, Betsholtz C (2006) Pericytes and vascular stability. Exp Cell Res 312(5):623–629. (PMID: 10.1016/j.yexcr.2005.10.019) ; Stratman AN, Davis GE (2012) Endothelial cell-pericyte interactions stimulate basement membrane matrix assembly: influence on vascular tube remodeling, maturation, and stabilization. Microsc Microanal 18(1):68–80. (PMID: 2216661710.1017/S1431927611012402) ; Hellstrom M, Gerhardt H, Kalen M et al (2001) Lack of pericytes leads to endothelial hyperplasia and abnormal vascular morphogenesis. J Cell Biol 153(3):543–553. (PMID: 11331305219057310.1083/jcb.153.3.543) ; Chen M, Lei X, Shi C et al (2017) Pericyte-targeting prodrug overcomes tumor resistance to vascular disrupting agents. J Clin Invest 127(10):3689–3701. (PMID: 28846068561766310.1172/JCI94258) ; Ruan J, Luo M, Wang C et al (2013) Imatinib disrupts lymphoma angiogenesis by targeting vascular pericytes. Blood 121(26):5192–5202. (PMID: 23632889369536310.1182/blood-2013-03-490763) ; Owens LV, Xu L, Craven RJ et al (1995) Overexpression of the focal adhesion kinase (p125FAK) in invasive human tumors. Cancer Res 55(13):2752–2755. (PMID: 7796399) ; Schmitz KJ, Grabellus F, Callies R et al (2005) High expression of focal adhesion kinase (p125FAK) in node-negative breast cancer is related to overexpression of HER-2/neu and activated Akt kinase but does not predict outcome. Breast Cancer Res 7(2):R194-203. (PMID: 15743500106413110.1186/bcr977) ; Ji HF, Pang D, Fu SB et al (2013) Overexpression of focal adhesion kinase correlates with increased lymph node metastasis and poor prognosis in non-small-cell lung cancer. J Cancer Res Clin Oncol 139(3):429–435. (PMID: 2314364610.1007/s00432-012-1342-8) ; Tavora B, Batista S, Reynolds LE et al (2010) Endothelial FAK is required for tumour angiogenesis. EMBO Mol Med 2(12):516–528. (PMID: 21154724337734410.1002/emmm.201000106) ; Sulzmaier FJ, Jean C, Schlaepfer DD (2014) FAK in cancer: mechanistic findings and clinical applications. Nat Rev Cancer 14(9):598–610. (PMID: 25098269436586210.1038/nrc3792) ; Lechertier T, Hodivala-Dilke K (2012) Focal adhesion kinase and tumour angiogenesis. J Pathol 226(2):404–412. (PMID: 2198445010.1002/path.3018) ; Lee J, Borboa AK, Chun HB et al (2010) Conditional deletion of the focal adhesion kinase FAK alters remodeling of the blood-brain barrier in glioma. Cancer Res 70(24):10131–10140. (PMID: 21159635305922010.1158/0008-5472.CAN-10-2740) ; Corsi JM, Houbron C, Billuart P et al (2009) Autophosphorylation-independent and -dependent functions of focal adhesion kinase during development. J Biol Chem 284(50):34769–34776. (PMID: 19776009278733910.1074/jbc.M109.067280) ; Pedrosa AR, Bodrug N, Gomez-Escudero J et al (2019) Tumor angiogenesis is differentially regulated by phosphorylation of endothelial cell focal adhesion kinase tyrosines-397 and -861. Can Res 79(17):4371–4386. (PMID: 10.1158/0008-5472.CAN-18-3934) ; Tavora B, Reynolds LE, Batista S et al (2014) Endothelial-cell FAK targeting sensitizes tumours to DNA-damaging therapy. Nature 514(7520):112–116. (PMID: 25079333453391610.1038/nature13541) ; Lechertier T, Reynolds LE, Kim H et al (2020) Pericyte FAK negatively regulates Gas6/Axl signalling to suppress tumour angiogenesis and tumour growth. Nat Commun 11(1):2810. (PMID: 32499572727265110.1038/s41467-020-16618-6) ; Wong PP, Munoz-Felix JM, Hijazi M et al (2020) Cancer burden is controlled by Mural cell-beta3-integrin regulated crosstalk with tumor cells. Cell 181(6):1346–1363. (PMID: 3247312610.1016/j.cell.2020.02.003) ; Viski C, Konig C, Kijewska M et al (2016) Endosialin-expressing pericytes promote metastatic dissemination. Can Res 76(18):5313–5325. (PMID: 10.1158/0008-5472.CAN-16-0932) ; Murgai M, Ju W, Eason M et al (2017) KLF4-dependent perivascular cell plasticity mediates pre-metastatic niche formation and metastasis. Nat Med 23(10):1176–1190. (PMID: 28920957572439010.1038/nm.4400) ; Baluk P, Lee CG, Link H et al (2004) Regulated angiogenesis and vascular regression in mice overexpressing vascular endothelial growth factor in airways. Am J Pathol 165(4):1071–1085. (PMID: 15466375161864610.1016/S0002-9440(10)63369-X) ; Inai T, Mancuso M, Hashizume H et al (2004) Inhibition of vascular endothelial growth factor (VEGF) signaling in cancer causes loss of endothelial fenestrations, regression of tumor vessels, and appearance of basement membrane ghosts. Am J Pathol 165(1):35–52. (PMID: 15215160161854010.1016/S0002-9440(10)63273-7) ; Gilbert LA, Hemann MT (2010) DNA damage-mediated induction of a chemoresistant niche. Cell 143(3):355–366. (PMID: 21029859297235310.1016/j.cell.2010.09.043) ; Cao Z, Ding BS, Guo P et al (2014) Angiocrine factors deployed by tumor vascular niche induce B cell lymphoma invasiveness and chemoresistance. Cancer Cell 25(3):350–365. (PMID: 24651014401792110.1016/j.ccr.2014.02.005) ; Armulik A, Genove G, Mae M et al (2010) Pericytes regulate the blood-brain barrier. Nature 468(7323):557–561. (PMID: 2094462710.1038/nature09522) ; Chen J, Luo Y, Hui H et al (2017) CD146 coordinates brain endothelial cell-pericyte communication for blood-brain barrier development. Proc Natl Acad Sci USA 114(36):E7622–E7631. (PMID: 28827364559469610.1073/pnas.1710848114) ; Aplin AC, Fogel E, Nicosia RF (2010) MCP-1 promotes mural cell recruitment during angiogenesis in the aortic ring model. Angiogenesis 13(3):219–226. (PMID: 20571857296728110.1007/s10456-010-9179-8) ; Gazzaniga S, Bravo AI, Guglielmotti A et al (2007) Targeting tumor-associated macrophages and inhibition of MCP-1 reduce angiogenesis and tumor growth in a human melanoma xenograft. J Invest Dermatol 127(8):2031–2041. (PMID: 1746073610.1038/sj.jid.5700827) ; Cranford TL, Velazquez KT, Enos RT et al (2017) Loss of monocyte chemoattractant protein-1 expression delays mammary tumorigenesis and reduces localized inflammation in the C3(1)/SV40Tag triple negative breast cancer model. Cancer Biol Ther 18(2):85–93. (PMID: 28075192536299710.1080/15384047.2016.1276135) ; Roberts WG, Ung E, Whalen P et al (2008) Antitumor activity and pharmacology of a selective focal adhesion kinase inhibitor, PF-562,271. Can Res 68(6):1935–1944. (PMID: 10.1158/0008-5472.CAN-07-5155) ; Duxbury MS, Ito H, Zinner MJ et al (2004) Focal adhesion kinase gene silencing promotes anoikis and suppresses metastasis of human pancreatic adenocarcinoma cells. Surgery 135(5):555–562. (PMID: 1511859310.1016/j.surg.2003.10.017) ; Stokes JB, Adair SJ, Slack-Davis JK et al (2011) Inhibition of focal adhesion kinase by PF-562,271 inhibits the growth and metastasis of pancreatic cancer concomitant with altering the tumor microenvironment. Mol Cancer Ther 10(11):2135–2145. (PMID: 21903606321327310.1158/1535-7163.MCT-11-0261) ; Alexopoulou AN, Lees DM, Bodrug N et al (2017) Focal Adhesion Kinase (FAK) tyrosine 397E mutation restores the vascular leakage defect in endothelium-specific FAK-kinase dead mice. J Pathol 242(3):358–370. (PMID: 28444899551844410.1002/path.4911) ; Huang FJ, You WK, Bonaldo P et al (2010) Pericyte deficiencies lead to aberrant tumor vascularizaton in the brain of the NG2 null mouse. Dev Biol 344(2):1035–1046. (PMID: 20599895319774410.1016/j.ydbio.2010.06.023) ; Cooke VG, LeBleu VS, Keskin D et al (2012) Pericyte depletion results in hypoxia-associated epithelial-to-mesenchymal transition and metastasis mediated by met signaling pathway. Cancer Cell 21(1):66–81. (PMID: 22264789399952210.1016/j.ccr.2011.11.024) ; Yoshida S, Kawai H, Eguchi T et al (2019) Tumor angiogenic inhibition triggered necrosis (TAITN) in oral cancer. Cells 8:7. (PMID: 10.3390/cells8070761) ; Ramanujan S, Koenig GC, Padera TP et al (2000) Local imbalance of proangiogenic and antiangiogenic factors: a potential mechanism of focal necrosis and dormancy in tumors. Can Res 60(5):1442–1448. ; Acharyya S, Oskarsson T, Vanharanta S et al (2012) A CXCL1 paracrine network links cancer chemoresistance and metastasis. Cell 150(1):165–178. (PMID: 22770218352801910.1016/j.cell.2012.04.042) ; Armstrong LC, Bjorkblom B, Hankenson KD et al (2002) Thrombospondin 2 inhibits microvascular endothelial cell proliferation by a caspase-independent mechanism. Mol Biol Cell 13(6):1893–1905. (PMID: 1205805711761210.1091/mbc.e01-09-0066) ; Li M, Knight DA, As L et al (2013) A role for CCL2 in both tumor progression and immunosurveillance. Oncoimmunology. 2(7):25474. (PMID: 10.4161/onci.25474) ; Yang X, Qiao D, Meyer K et al (2012) Angiogenesis induced by signal transducer and activator of transcription 5A (STAT5A) is dependent on autocrine activity of proliferin. J Biol Chem 287(9):6490–6502. (PMID: 2219935010.1074/jbc.M111.254631) ; Carpen T, Sorsa T, Jouhi L et al (2019) High levels of tissue inhibitor of metalloproteinase-1 (TIMP-1) in the serum are associated with poor prognosis in HPV-negative squamous cell oropharyngeal cancer. Cancer Immunol Immunother 68(8):1263–1272. (PMID: 31240326668257110.1007/s00262-019-02362-4) ; Takahara M, Nagato T, Komabayashi Y et al (2013) Soluble ICAM-1 secretion and its functional role as an autocrine growth factor in nasal NK/T cell lymphoma cells. Exp Hematol 41(8):711–718. (PMID: 2358364010.1016/j.exphem.2013.03.009) ; Tang Z, Gillatt D, Rowe E et al (2019) IGFBP-2 acts as a tumour suppressor and plays a role in determining chemosensitivity in bladder cancer cells. Oncotarget 10(66):7043–7057. (PMID: 31903164692502610.18632/oncotarget.27355) ; Folkman J (2006) Antiangiogenesis in cancer therapy–endostatin and its mechanisms of action. Exp Cell Res 312(5):594–607. (PMID: 1637633010.1016/j.yexcr.2005.11.015) ; Vazquez F, Hastings G, Ortega MA et al (1999) METH-1, a human ortholog of ADAMTS-1, and METH-2 are members of a new family of proteins with angio-inhibitory activity. J Biol Chem 274(33):23349–23357. (PMID: 1043851210.1074/jbc.274.33.23349) ; Sandilands E, Serrels B, McEwan DG et al (2011) Autophagic targeting of Src promotes cancer cell survival following reduced FAK signalling. Nat Cell Biol 14(1):51–60. (PMID: 2213857510.1038/ncb2386) ; Beausejour M, Noel D, Thibodeau S et al (2012) Integrin/Fak/Src-mediated regulation of cell survival and anoikis in human intestinal epithelial crypt cells: selective engagement and roles of PI3-K isoform complexes. Apoptosis 17(6):566–578. (PMID: 22402981334518110.1007/s10495-012-0713-6) ; Lim ST, Chen XL, Tomar A et al (2010) Knock-in mutation reveals an essential role for focal adhesion kinase activity in blood vessel morphogenesis and cell motility-polarity but not cell proliferation. J Biol Chem 285(28):21526–21536. (PMID: 20442405289842810.1074/jbc.M110.129999) ; Tavora B, Batista S, Alexopoulou AN et al (2014) Generation of point-mutant FAK knockin mice. Genesis 52(11):907–915. (PMID: 2524269810.1002/dvg.22823) ; Tigges U, Welser-Alves JV, Boroujerdi A et al (2012) A novel and simple method for culturing pericytes from mouse brain. Microvasc Res 84(1):74–80. (PMID: 22484453374813810.1016/j.mvr.2012.03.008) ; Reynolds LE, D’Amico G, Lechertier T et al (2017) Dual role of pericyte alpha6beta1-integrin in tumour blood vessels. J Cell Sci 130(9):1583–1595. (PMID: 282892675450232) ; Baker M, Robinson SD, Lechertier T et al (2012) Use of the mouse aortic ring assay to study angiogenesis. Nat Protoc 7(1):89–104. (PMID: 10.1038/nprot.2011.435)
- Grant Information: 28990 United Kingdom CRUK_ Cancer Research UK; C82181/A12007 United Kingdom CRUK_ Cancer Research UK
- Contributed Indexing: Keywords: Angiogenesis; Cancer; Focal adhesion kinase (FAK); Pericytes
- Substance Nomenclature: 0 (Neoplasm Proteins) ; EC 2.7.10.2 (Focal Adhesion Kinase 1) ; EC 2.7.10.2 (Ptk2 protein, mouse)
- Entry Date(s): Date Created: 20210317 Date Completed: 20220114 Latest Revision: 20240210
- Update Code: 20240210
- PubMed Central ID: PMC8292267
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