Einzeltreffer — DigiBib

The calcium Sensing Receptor (CaSR) is a cell surface receptor belonging to the family of G-protein coupled receptors. CaSR is mainly expressed by parathyroid glands, kidneys, bone, skin, adipose tissue, the gut, the nervous system, and the cardiovascular system. The receptor, as its name implies is involved in sensing calcium fluctuations in the extracellular matrix of cells, thereby having a major impact on the mineral homeostasis in humans. Besides calcium ions, the receptor is also activated by other di- and tri-valent cations, polypeptides, polyamines, antibiotics, calcilytics and calcimimetics, which upon binding induce intracellular signaling pathways. Recent studies have demonstrated that CaSR influences a wide variety of cells and processes that are involved in inflammation, the cardiovascular system, such as vascular calcification, atherosclerosis, myocardial infarction, hypertension, and obesity. Therefore, in this review, the current understanding of the role that CaSR plays in inflammation and its consequences on the cardiovascular system will be highlighted.

Titel:	Calcium-Sensing Receptor (CaSR), Its Impact on Inflammation and the Consequences on Cardiovascular Health.
Autor/in / Beteiligte Person:	Sundararaman, SS ; van der Vorst EPC
Link:	Full Text Finder (Volltext)
Zeitschrift:	International journal of molecular sciences, Jg. 22 (2021-03-01), Heft 5
Veröffentlichung:	Basel, Switzerland : MDPI, [2000-, 2021
Medientyp:	academicJournal
ISSN:	1422-0067 (electronic)
DOI:	10.3390/ijms22052478
Schlagwort:	Animals Cardiovascular Diseases metabolism Humans Inflammation metabolism Signal Transduction Calcium metabolism Cardiovascular Diseases physiopathology Inflammation physiopathology Receptors, Calcium-Sensing metabolism
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: English Publication Type: Journal Article; Review Language: English [Int J Mol Sci] 2021 Mar 01; Vol. 22 (5). <i>Date of Electronic Publication: </i>2021 Mar 01. MeSH Terms: Calcium / metabolism ; Cardiovascular Diseases / physiopathology ; Inflammation / physiopathology ; Receptors, Calcium-Sensing / metabolism ; Animals ; Cardiovascular Diseases / metabolism ; Humans ; Inflammation / metabolism ; Signal Transduction References: Mediators Inflamm. 2019 Feb 13;2019:6847087. (PMID: 30906225) ; Vascul Pharmacol. 2017 Sep;96-98:53-62. (PMID: 28867591) ; Front Physiol. 2018 May 08;9:413. (PMID: 29867518) ; Front Physiol. 2016 Oct 18;7:458. (PMID: 27803672) ; Int J Mol Sci. 2018 Mar 27;19(4):. (PMID: 29584660) ; Vascul Pharmacol. 2016 May;80:75-84. (PMID: 26772767) ; Am J Physiol Gastrointest Liver Physiol. 2020 Jan 1;318(1):G144-G161. (PMID: 31709833) ; Biochem Biophys Res Commun. 2006 Dec 1;350(4):942-8. 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(PMID: 27386547) ; J Biol Chem. 2007 Aug 24;282(34):25030-40. (PMID: 17591780) Grant Information: n.a. interdisciplinary center for clinical research within the faculty of medicine at the RWTH Aachen university; n.a. Deutsches Zentrum für Herz-Kreislaufforschung; 91619053 Nederlandse Organisatie voor Wetenschappelijk Onderzoek Contributed Indexing: Keywords: CaSR; G-protein coupled receptors; adipose tissue; atherosclerosis; calcium-sensing receptor; cardiovascular disorders; hypertension; inflammation; myocardial ischemia; vascular calcification Substance Nomenclature: 0 (Receptors, Calcium-Sensing) ; SY7Q814VUP (Calcium) Entry Date(s): Date Created: 20210403 Date Completed: 20210427 Latest Revision: 20210427 Update Code: 20240513 PubMed Central ID: PMC7957814

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Calcium-Sensing Receptor (CaSR), Its Impact on Inflammation and the Consequences on Cardiovascular Health.