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Among multiple mechanisms, low-grade inflammation is critical for the development of insulin resistance as a feature of type 2 diabetes. The nucleotide-binding oligomerization domain-like receptor family (NOD-like) pyrin domain containing 3 (NLRP3) inflammasome has been linked to the development of insulin resistance in various tissues; however, its role in the development of insulin resistance in the skeletal muscle has not been explored in depth. Currently, there is limited evidence that supports the pathological role of NLRP3 inflammasome activation in glucose handling in the skeletal muscle of obese individuals. Here, we have centered our focus on insulin signaling in skeletal muscle, which is the main site of postprandial glucose disposal in humans. We discuss the current evidence showing that the NLRP3 inflammasome disturbs glucose homeostasis. We also review how NLRP3-associated interleukin and its gasdermin D-mediated efflux could affect insulin-dependent intracellular pathways. Finally, we address pharmacological NLRP3 inhibitors that may have a therapeutical use in obesity-related metabolic alterations.

Titel:	NLRP3 Inflammasome: Potential Role in Obesity Related Low-Grade Inflammation and Insulin Resistance in Skeletal Muscle.
Autor/in / Beteiligte Person:	Jorquera, G ; Russell, J ; Monsalves-Álvarez, M ; Cruz, G ; Valladares-Ide, D ; Basualto-Alarcón, C ; Barrientos, G ; Estrada, M ; Llanos, P
Link:	Full Text Finder (Volltext)
Zeitschrift:	International journal of molecular sciences, Jg. 22 (2021-03-23), Heft 6
Veröffentlichung:	Basel, Switzerland : MDPI, [2000-, 2021
Medientyp:	academicJournal
ISSN:	1422-0067 (electronic)
DOI:	10.3390/ijms22063254
Schlagwort:	Animals Biological Transport Chronic Disease Glucose metabolism Humans Inflammation drug therapy Inflammation pathology Interleukin-1beta metabolism Lipid Metabolism Muscle, Skeletal pathology Obesity drug therapy Obesity pathology Reactive Oxygen Species metabolism Signal Transduction Inflammasomes metabolism Inflammation etiology Inflammation metabolism Insulin Resistance Muscle, Skeletal metabolism NLR Family, Pyrin Domain-Containing 3 Protein metabolism Obesity etiology Obesity metabolism
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: English Publication Type: Journal Article; Review Language: English [Int J Mol Sci] 2021 Mar 23; Vol. 22 (6). <i>Date of Electronic Publication: </i>2021 Mar 23. MeSH Terms: Insulin Resistance* ; Inflammasomes / metabolism ; Inflammation / etiology ; Inflammation / metabolism ; Muscle, Skeletal / metabolism ; NLR Family, Pyrin Domain-Containing 3 Protein / metabolism ; Obesity / etiology ; Obesity / *metabolism ; Animals ; Biological Transport ; Chronic Disease ; Glucose / metabolism ; Humans ; Inflammation / drug therapy ; Inflammation / pathology ; Interleukin-1beta / metabolism ; Lipid Metabolism ; Muscle, Skeletal / pathology ; Obesity / drug therapy ; Obesity / pathology ; Reactive Oxygen Species / metabolism ; Signal Transduction References: Am J Physiol. 1999 Oct;277(4):C766-76. (PMID: 10516107) ; Life Sci. 2000 Jun 8;67(3):291-300. (PMID: 10983873) ; FEBS Lett. 1987 Aug 17;220(2):288-90. (PMID: 3609324) ; Biochem J. 1978 Jan 15;170(1):17-22. (PMID: 629775) ; Front Immunol. 2013 Mar 08;4:50. (PMID: 23483669) ; Biochem Biophys Res Commun. 2011 Sep 9;412(4):618-25. (PMID: 21856284) ; Nat Immunol. 2008 Aug;9(8):847-56. (PMID: 18604214) ; Clin Nutr. 2011 Aug;30(4):416-21. (PMID: 21481501) ; Eur J Immunol. 2010 Mar;40(3):620-3. (PMID: 20201015) ; Oxid Med Cell Longev. 2014;2014:102158. (PMID: 25215171) ; Cell Death Dis. 2018 Mar 2;9(3):351. (PMID: 29500339) ; N Engl J Med. 1993 Jan 14;328(2):106-13. (PMID: 8439348) ; Science. 1996 Feb 2;271(5249):665-8. (PMID: 8571133) ; Int J Mol Sci. 2014 Dec 26;16(1):378-400. (PMID: 25548896) ; Am J Clin Nutr. 2018 Oct 1;108(4):857-867. (PMID: 30239561) ; Front Med. 2013 Mar;7(1):14-24. (PMID: 23471659) ; Wiley Interdiscip Rev Syst Biol Med. 2020 Jan;12(1):e1462. (PMID: 31407867) ; Mol Metab. 2018 Nov;17:71-81. (PMID: 30174227) ; Am J Physiol Cell Physiol. 2016 Jul 1;311(1):C83-C100. (PMID: 27170638) ; Mar Drugs. 2017 Jun 25;15(7):. (PMID: 28672825) ; Endocrinology. 2007 Jan;148(1):241-51. (PMID: 17038556) ; Am J Physiol Endocrinol Metab. 2008 May;294(5):E882-8. (PMID: 18319352) ; Physiol Rev. 2000 Oct;80(4):1411-81. (PMID: 11015618) ; Front Nutr. 2019 Jun 13;6:87. (PMID: 31263701) ; Intensive Care Med Exp. 2017 Dec;5(1):3. (PMID: 28097512) ; Eur J Pharmacol. 1996 Feb 22;297(3):293-8. (PMID: 8666062) ; Front Endocrinol (Lausanne). 2013 May 10;4:52. (PMID: 23675368) ; Genes Nutr. 2009 Sep;4(3):215-22. (PMID: 19707810) ; Hepatology. 2018 May;67(5):1737-1753. (PMID: 29108122) ; Diabetes. 2011 Nov;60(11):2810-9. (PMID: 21911750) ; Int J Mol Sci. 2020 Jun 11;21(11):. (PMID: 32545355) ; Diabetes. 2008 Oct;57(10):2595-602. (PMID: 18633101) ; Mol Nutr Food Res. 2010 Jul;54(7):1014-20. (PMID: 20166142) ; Johns Hopkins Med J. 1976 May;138(5):167-79. (PMID: 940250) ; Sci STKE. 2005 Nov 29;2005(312):re13. (PMID: 16317114) ; Int J Mol Sci. 2013 Jul 29;14(8):15740-54. (PMID: 23899788) ; Diabetes Care. 2009 Nov;32 Suppl 2:S157-63. (PMID: 19875544) ; Diabetologia. 2020 Nov;63(11):2471-2481. (PMID: 32840676) ; Endocrinology. 2004 Oct;145(10):4592-602. (PMID: 15256490) ; J Endocrinol. 2017 Apr;233(1):R15-R42. (PMID: 28232636) ; Diabetes. 2020 May;69(5):848-858. (PMID: 32312901) ; Annu Rev Immunol. 2011;29:415-45. (PMID: 21219177) ; Am J Physiol Endocrinol Metab. 2001 Oct;281(4):E789-93. (PMID: 11551856) ; Diabetes. 2006 May;55(5):1300-6. (PMID: 16644686) ; Am J Physiol Regul Integr Comp Physiol. 2014 Dec 15;307(12):R1413-27. (PMID: 25209413) ; Int J Mol Med. 2015 Sep;36(3):839-44. (PMID: 26166692) ; Nature. 1995 Nov 2;378(6552):88-91. (PMID: 7477296) ; J Clin Invest. 1985 Jul;76(1):357-64. (PMID: 3894421) ; J Clin Endocrinol Metab. 2001 Dec;86(12):5755-61. (PMID: 11739435) ; Physiology (Bethesda). 2005 Aug;20:260-70. (PMID: 16024514) ; Front Biosci (Landmark Ed). 2020 Jan 1;25:283-298. (PMID: 31585890) ; Front Immunol. 2018 Oct 08;9:2305. (PMID: 30349539) ; J Pharmacol Exp Ther. 1983 Oct;227(1):199-204. (PMID: 6312018) ; Nat Commun. 2020 Aug 25;11(1):4243. (PMID: 32843625) ; Am J Physiol Cell Physiol. 2014 May 15;306(10):C879-86. (PMID: 24598362) ; Antioxidants (Basel). 2017 Jun 29;6(3):. (PMID: 28661427) ; PLoS One. 2016 Jul 25;11(7):e0158209. (PMID: 27453994) ; Nat Immunol. 2011 May;12(5):408-15. (PMID: 21478880) ; J Clin Endocrinol Metab. 2010 Apr;95(4):1861-8. (PMID: 20164293) ; Endocr Rev. 2020 Jun 1;41(3):. (PMID: 32179913) ; Diabetologia. 2021 Mar 12;:. (PMID: 33710396) ; J Clin Invest. 2006 Nov;116(11):3015-25. (PMID: 17053832) ; Nat Med. 2015 Mar;21(3):248-55. (PMID: 25686105) ; Nature. 2006 Mar 9;440(7081):228-32. (PMID: 16407890) ; Mol Cell Biochem. 2017 Feb;426(1-2):27-45. (PMID: 27868170) ; Redox Biol. 2018 Jun;16:32-46. (PMID: 29475133) ; Inflamm Res. 2017 Feb;66(2):157-166. (PMID: 27785530) ; FASEB J. 2010 Aug;24(8):2596-611. (PMID: 20371626) ; Biochem Soc Trans. 2017 Aug 15;45(4):979-985. (PMID: 28710289) ; Am J Physiol Endocrinol Metab. 2010 Mar;298(3):E706-13. (PMID: 20028967) ; Nat Rev Endocrinol. 2012 Apr 03;8(8):457-65. (PMID: 22473333) ; Compr Physiol. 2013 Jul;3(3):1337-62. (PMID: 23897689) ; PLoS Med. 2007 May;4(5):e158. (PMID: 17472435) ; PLoS One. 2018 Jul 26;13(7):e0201050. (PMID: 30048500) ; Am J Physiol. 1999 Dec;277(6):E1130-41. (PMID: 10600804) ; J Biol Chem. 2002 Jan 11;277(2):1531-7. (PMID: 11606564) ; Obesity (Silver Spring). 2016 Nov;24(11):2301-2310. (PMID: 27804267) ; Immunity. 2018 Jan 16;48(1):35-44.e6. (PMID: 29195811) ; Int J Mol Sci. 2019 Jul 27;20(15):. (PMID: 31357643) ; Cell. 2004 May 28;117(5):561-74. (PMID: 15163405) ; PLoS One. 2019 Jan 18;14(1):e0211005. (PMID: 30657794) ; Part Fibre Toxicol. 2016 Apr 23;13:19. (PMID: 27108091) ; Diabetes. 2005 Jun;54(6):1692-7. (PMID: 15919790) ; Autophagy. 2017 Apr 3;13(4):642-653. (PMID: 28121218) ; PLoS One. 2014 Oct 22;9(10):e110653. (PMID: 25337938) ; J Biol Chem. 2000 Mar 24;275(12):9047-54. (PMID: 10722755) ; Nat Immunol. 2010 Feb;11(2):136-40. (PMID: 20023662) ; Trends Biochem Sci. 2017 Apr;42(4):245-254. (PMID: 27932073) ; Cell Mol Immunol. 2016 Mar;13(2):148-59. (PMID: 26549800) ; Diabetologia. 2006 Sep;49(9):2162-73. (PMID: 16865359) ; Nat Rev Endocrinol. 2018 Dec;15(1):33-51. (PMID: 30443043) ; Mol Med. 2016 Mar;21(1):1025-1037. (PMID: 26623925) ; Diabetes Res Clin Pract. 2017 Jun;128:40-50. (PMID: 28437734) ; J Cell Biol. 2009 Oct 5;187(1):61-70. (PMID: 19805629) ; Int Immunopharmacol. 2019 Sep;74:105575. (PMID: 31299609) ; Diabetologia. 1996 Oct;39(10):1180-9. (PMID: 8897005) ; Mamm Genome. 2000 Sep;11(9):718-24. (PMID: 10967128) ; J Alzheimers Dis. 2019;68(1):255-265. (PMID: 30741672) ; Nat Rev Immunol. 2015 Feb;15(2):104-16. (PMID: 25614320) ; Nat Med. 2011 Feb;17(2):179-88. (PMID: 21217695) ; J Inflamm Res. 2015 Jan 16;8:15-27. (PMID: 25653548) ; Mol Cell Biol. 2010 Jan;30(1):106-15. (PMID: 19841069) ; Phys Ther. 1993 Dec;73(12):878-91. (PMID: 8248296) ; J Nutr Biochem. 2015 Dec;26(12):1599-606. (PMID: 26324406) ; Int J Biochem Cell Biol. 2018 May;98:43-53. (PMID: 29477360) ; Nature. 2010 Apr 29;464(7293):1357-61. (PMID: 20428172) ; Nat Toxins. 1994;2(2):64-72. (PMID: 8075895) ; Clin Biochem Rev. 2005 May;26(2):19-39. (PMID: 16278749) ; Annu Rev Immunol. 2011;29:707-35. (PMID: 21219188) ; Biochem Pharmacol. 2013 Jan 15;85(2):257-64. (PMID: 23103566) ; Diabetes. 2003 Sep;52(9):2411-8. (PMID: 12941783) ; Atherosclerosis. 2019 Oct;289:132-142. (PMID: 31513948) ; Am J Physiol. 1997 Dec;273(6):C1793-800. (PMID: 9435482) ; Neuropharmacology. 2020 Dec 1;180:108305. (PMID: 32931815) ; BMC Biol. 2018 Mar 20;16(1):33. (PMID: 29558930) ; Am J Physiol Endocrinol Metab. 2006 Jul;291(1):E108-14. (PMID: 16464907) ; J Clin Invest. 1985 Jul;76(1):149-55. (PMID: 3894418) ; J Immunol. 2011 Feb 15;186(4):2529-34. (PMID: 21257968) ; Nat Rev Immunol. 2010 Mar;10(3):210-5. (PMID: 20168318) ; Nat Med. 2015 Jul;21(7):677-87. (PMID: 26121197) ; Obes Rev. 2012 Dec;13 Suppl 2:51-7. (PMID: 23107259) ; Molecules. 2018 Feb 27;23(3):. (PMID: 29495433) ; Lipids Health Dis. 2012 Feb 23;11:30. (PMID: 22360800) ; Diabetes. 2008 Sep;57(9):2311-20. (PMID: 18567823) ; Autophagy. 2020 Aug 24;:1-15. (PMID: 32835606) ; Diabetes. 2008 Feb;57(2):315-24. (PMID: 17977960) ; J Clin Invest. 1998 Jun 1;101(11):2377-86. (PMID: 9616209) ; Curr Opin Lipidol. 2003 Jun;14(3):281-7. (PMID: 12840659) ; Cell Metab. 2010 Dec 1;12(6):593-605. (PMID: 21109192) ; JCI Insight. 2018 Feb 8;3(3):. (PMID: 29415895) ; J Neuroinflammation. 2020 Sep 21;17(1):280. (PMID: 32958021) ; Annu Rev Biochem. 1976;45:501-30. (PMID: 786156) ; Biochem Biophys Res Commun. 2012 Jan 6;417(1):352-7. (PMID: 22155234) ; Proc Natl Acad Sci U S A. 2011 Sep 13;108(37):15324-9. (PMID: 21876127) ; Med Sci Sports Exerc. 2020 Dec 11;:. (PMID: 33315811) ; Shock. 2003 Jun;19(6):538-46. (PMID: 12785009) ; Immunol Rev. 2015 May;265(1):53-62. (PMID: 25879283) ; Inflammation. 2017 Feb;40(1):21-41. (PMID: 27730320) ; Int J Mol Sci. 2018 Sep 18;19(9):. (PMID: 30231482) ; Nature. 2015 Oct 29;526(7575):660-5. (PMID: 26375003) ; Free Radic Biol Med. 2011 Sep 1;51(5):993-9. (PMID: 21163347) ; Nature. 2002 Nov 21;420(6913):333-6. (PMID: 12447443) ; PLoS One. 2013 Jun 12;8(6):e66322. (PMID: 23776659) ; Eur J Pharmacol. 1992 Sep 1;227(1):43-9. (PMID: 1330638) ; J Cell Biol. 1996 Oct;135(2):415-30. (PMID: 8896598) ; Am J Physiol Endocrinol Metab. 2017 Aug 1;313(2):E222-E232. (PMID: 28536183) ; Biomed J. 2017 Dec;40(6):313-316. (PMID: 29433834) ; J Clin Invest. 2017 Jan 3;127(1):43-54. (PMID: 28045398) ; Am J Physiol Endocrinol Metab. 2000 Nov;279(5):E1039-44. (PMID: 11052958) ; Aging Cell. 2014 Dec;13(6):1001-11. (PMID: 25139155) ; Proc Natl Acad Sci U S A. 2019 Jul 2;116(27):13533-13542. (PMID: 31196960) ; Diabetes. 1982 Nov;31(11):957-63. (PMID: 6757014) ; Int J Obes (Lond). 2015 Nov;39(11):1607-18. (PMID: 26041698) ; J Appl Physiol (1985). 2004 Oct;97(4):1170-87. (PMID: 15358749) ; Oxid Med Cell Longev. 2017;2017:3165396. (PMID: 28656072) ; Immunol Rev. 2015 May;265(1):35-52. (PMID: 25879282) ; J Clin Invest. 2009 Mar;119(3):573-81. (PMID: 19188683) ; Immunity. 2018 Jan 16;48(1):1-3. (PMID: 29343431) ; Endocrinol Metab (Seoul). 2017 Jun;32(2):257-264. (PMID: 28555462) ; Biochem Biophys Res Commun. 2010 Nov 19;402(3):455-60. (PMID: 20946888) ; Nat Immunol. 2020 Jul;21(7):736-745. (PMID: 32367036) ; Obesity (Silver Spring). 2014 Mar;22(3):747-57. (PMID: 24030890) ; Biochimie. 2013 Feb;95(2):347-53. (PMID: 23079337) ; Diabetologia. 2014 Aug;57(8):1674-83. (PMID: 24891017) ; J Food Drug Anal. 2018 Jul;26(3):1066-1074. (PMID: 29976399) ; Cell Metab. 2016 Jan 12;23(1):155-64. (PMID: 26603191) ; Diabetologia. 2013 Jul;56(7):1623-8. (PMID: 23595247) ; Cell Metab. 2020 Aug 4;32(2):203-214.e4. (PMID: 32413333) ; Diabetes Care. 2004 Jan;27(1):272. (PMID: 14694002) Grant Information: 1190406 Fondo Nacional de Desarrollo Científico y Tecnológico; 1201816 Fondo Nacional de Desarrollo Científico y Tecnológico; 11190949 Fondo Nacional de Desarrollo Científico y Tecnológico; 170032 REDES-ANID; DIUV-CI 01/2006 Centro de Neurobiología y Fisiopatología Integrativa (CENFI), Universidad de Valparaíso Contributed Indexing: Keywords: NALP3; chronic inflammation; glucose transport; muscle Substance Nomenclature: 0 (Inflammasomes) ; 0 (Interleukin-1beta) ; 0 (NLR Family, Pyrin Domain-Containing 3 Protein) ; 0 (Reactive Oxygen Species) ; IY9XDZ35W2 (Glucose) Entry Date(s): Date Created: 20210403 Date Completed: 20210510 Latest Revision: 20210510 Update Code: 20231215 PubMed Central ID: PMC8005007

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NLRP3 Inflammasome: Potential Role in Obesity Related Low-Grade Inflammation and Insulin Resistance in Skeletal Muscle.