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The health effects of omega-3 fatty acids have been controversial. Here we report the results of a de novo pooled analysis conducted with data from 17 prospective cohort studies examining the associations between blood omega-3 fatty acid levels and risk for all-cause mortality. Over a median of 16 years of follow-up, 15,720 deaths occurred among 42,466 individuals. We found that, after multivariable adjustment for relevant risk factors, risk for death from all causes was significantly lower (by 15-18%, at least p < 0.003) in the highest vs the lowest quintile for circulating long chain (20-22 carbon) omega-3 fatty acids (eicosapentaenoic, docosapentaenoic, and docosahexaenoic acids). Similar relationships were seen for death from cardiovascular disease, cancer and other causes. No associations were seen with the 18-carbon omega-3, alpha-linolenic acid. These findings suggest that higher circulating levels of marine n-3 PUFA are associated with a lower risk of premature death.

Titel:	Blood n-3 fatty acid levels and total and cause-specific mortality from 17 prospective studies.
Autor/in / Beteiligte Person:	Harris, WS ; Tintle, NL ; Imamura, F ; Qian, F ; Korat, AVA ; Marklund, M ; Djoussé, L ; Bassett, JK ; Carmichael, PH ; Chen, YY ; Hirakawa, Y ; Küpers, LK ; Laguzzi, F ; Lankinen, M ; Murphy, RA ; Samieri, C ; Senn, MK ; Shi, P ; Virtanen, JK ; Brouwer, IA ; Chien, KL ; Eiriksdottir, G ; Forouhi, NG ; Geleijnse, JM ; Giles, GG ; Gudnason, V ; Helmer, C ; Hodge, A ; Jackson, R ; Khaw, KT ; Laakso, M ; Lai, H ; Laurin, D ; Leander, K ; Lindsay, J ; Micha, R ; Mursu, J ; Ninomiya, T ; Post, W ; Psaty, BM ; Risérus, U ; Robinson, JG ; Shadyab, AH ; Snetselaar, L ; Sala-Vila, A ; Sun, Y ; Steffen, LM ; Tsai, MY ; Wareham, NJ ; Wood, AC ; Wu, JHY ; Hu, F ; Sun, Q ; Siscovick, DS ; Lemaitre, RN ; Mozaffarian, D
Link:	Full Text Finder (Volltext)
Zeitschrift:	Nature communications, Jg. 12 (2021-04-22), Heft 1, S. 2329
Veröffentlichung:	[London] : Nature Pub. Group, 2021
Medientyp:	academicJournal
ISSN:	2041-1723 (electronic)
DOI:	10.1038/s41467-021-22370-2
Schlagwort:	Aged Aged, 80 and over Female Follow-Up Studies Humans Male Middle Aged Prospective Studies Protective Factors Risk Factors Cause of Death Fatty Acids, Omega-3 blood Mortality, Premature
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: English Corporate Authors: Fatty Acids and Outcomes Research Consortium (FORCE) Publication Type: Journal Article; Meta-Analysis Language: English [Nat Commun] 2021 Apr 22; Vol. 12 (1), pp. 2329. <i>Date of Electronic Publication: </i>2021 Apr 22. MeSH Terms: Cause of Death* ; Mortality, Premature* ; Fatty Acids, Omega-3 / *blood ; Aged ; Aged, 80 and over ; Female ; Follow-Up Studies ; Humans ; Male ; Middle Aged ; Prospective Studies ; Protective Factors ; Risk Factors References: Dyerberg, J., Bang, H. O., Stoffersen, E., Moncada, S. & Vane, J. R. Eicosapentaenoic acid and prevention of thrombosis and atherosclerosis? Lancet 2, 117–119 (1978). ; Bang, H. O. & Dyerberg, J. Lipid metabolism and ischemic heart disease in greenland eskimos. Adv. Nutr. Res. 3, 1–22 (1980). ; Hu, Y., Hu, F. B. & Manson, J. E. 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Grant Information: MC_UU_00006/1 United Kingdom MRC_ Medical Research Council; MC_UU_12015/1 United Kingdom MRC_ Medical Research Council; T32 CA009001 United States CA NCI NIH HHS; MC_UU_12015/5 United Kingdom MRC_ Medical Research Council; MC_UU_00006/3 United Kingdom MRC_ Medical Research Council Substance Nomenclature: 0 (Fatty Acids, Omega-3) Entry Date(s): Date Created: 20210423 Date Completed: 20210511 Latest Revision: 20230201 Update Code: 20240513 PubMed Central ID: PMC8062567

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Blood n-3 fatty acid levels and total and cause-specific mortality from 17 prospective studies.