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Background/aim: Xeroderma pigmentosum complementation group C (XPC) is reported to play important roles in DNA integrity and genomic instability, however, the contribution of XPC to oral carcinogenesis is largely uncertain. Therefore, we aimed at examining the contribution of XPC genotypes to oral cancer.

Materials and Methods: The genotypes of XPC rs2228001 and rs2228000 were examined among 958 oral cancer patients and 958 control subjects by polymerase chain reaction-restriction fragment length polymorphism methodology and corresponding DNA repair capacity was checked.

Results: First, the percentages of XPC rs2228001 AC and CC were higher among oral cancer patients than controls. Second, no significant association was observed regarding XPC rs2228000. Third, there was a synergistic influence of smoking and betel quid chewing behaviors and XPC rs2228001 genotype on oral cancer risk. Last, functional experiments showed DNA repair capacity was lower for AC/CC carriers than AA carriers.

Conclusion: XPC rs2228001 C allele, which was associated with decreased DNA repair capacity, may interact with smoking and betel quid chewing behaviors on oral cancer risk.

Titel:	Interaction of DNA Repair Gene XPC With Smoking and Betel Quid Chewing Behaviors of Oral Cancer.
Autor/in / Beteiligte Person:	Wu, CN ; Chang, WS ; Shih, LC ; Wang, YC ; Lee, HT ; Yu, CC ; Wang, ZH ; Mong, MC ; Hsia, TC ; Tsai, CW ; Bau, DT
Link:	Full Text Finder (Volltext)
Zeitschrift:	Cancer genomics & proteomics, Jg. 18 (2021-05-01), Heft 3 Suppl, S. 441-449
Veröffentlichung:	Kapandriti, Attiki, Greece : International Institute of Anticancer Research, [2004]-, 2021
Medientyp:	academicJournal
ISSN:	1790-6245 (electronic)
DOI:	10.21873/cgp.20270
Schlagwort:	Female Humans Male Middle Aged Mouth Neoplasms pathology Areca chemistry DNA Repair genetics DNA-Binding Proteins metabolism Mouth Neoplasms etiology Mouth Neoplasms genetics Smoking adverse effects
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: English Publication Type: Journal Article Language: English [Cancer Genomics Proteomics] 2021 May-Jun; Vol. 18 (3 Suppl), pp. 441-449. MeSH Terms: Areca / chemistry ; DNA Repair / genetics ; DNA-Binding Proteins / metabolism ; Mouth Neoplasms / etiology ; Mouth Neoplasms / genetics ; Smoking / adverse effects ; Female ; Humans ; Male ; Middle Aged ; Mouth Neoplasms / pathology References: Nat Rev Cancer. 2001 Oct;1(1):22-33. (PMID: 11900249) ; Int J Cancer. 2005 Jun 20;115(3):478-83. (PMID: 15700316) ; Int J Cancer. 2005 Jul 10;115(5):807-13. (PMID: 15729698) ; BMC Cancer. 2011 Mar 22;11:101. (PMID: 21426550) ; Int J Mol Epidemiol Genet. 2012;3(1):1-17. (PMID: 22493747) ; Cancer Epidemiol Biomarkers Prev. 2005 Nov;14(11 Pt 1):2524-30. (PMID: 16284373) ; J Clin Med. 2019 Jan 01;8(1):. (PMID: 30609649) ; In Vivo. 2021 Mar-Apr;35(2):799-803. (PMID: 33622872) ; Pathol Oncol Res. 2017 Jan;23(1):117-123. (PMID: 27571987) ; Mutat Res. 2010 Dec 10;694(1-2):39-44. (PMID: 20887739) ; J Surg Res. 2011 May 1;167(1):e5-12. (PMID: 21324488) ; Cancer Epidemiol Biomarkers Prev. 2002 Dec;11(12):1513-30. (PMID: 12496039) ; Genes (Basel). 2016 Sep 24;7(10):. (PMID: 27669310) ; Oncotarget. 2016 Feb 9;7(6):6972-83. (PMID: 26760766) ; Int J Cancer. 2013 Oct 15;133(8):1765-75. (PMID: 23400628) ; Science. 2001 Feb 16;291(5507):1284-9. (PMID: 11181991) ; Anticancer Res. 2020 Oct;40(10):5503-5508. (PMID: 32988873) ; In Vivo. 2013 Nov-Dec;27(6):707-14. (PMID: 24292572) ; Clin Cancer Res. 2007 Jun 15;13(12):3753-8. (PMID: 17575242) ; In Vivo. 2019 Jul-Aug;33(4):1151-1156. (PMID: 31280204) ; Mol Cell Biol. 2000 Nov;20(21):7980-90. (PMID: 11027268) ; Mol Biol Rep. 2011 Nov;38(8):5379-86. (PMID: 21390502) ; CA Cancer J Clin. 2021 Jan;71(1):7-33. (PMID: 33433946) ; In Vivo. 2020 Jul-Aug;34(4):1759-1764. (PMID: 32606144) ; J Food Biochem. 2019 Jul;43(7):e12902. (PMID: 31353708) ; Anticancer Res. 2018 Dec;38(12):6821-6826. (PMID: 30504396) ; Mol Carcinog. 2003 Sep;38(1):1-13. (PMID: 12949838) ; Am J Hum Genet. 2006 Mar;78(3):464-79. (PMID: 16465622) ; Medicine (Baltimore). 2018 Sep;97(36):e12135. (PMID: 30200105) ; Carcinogenesis. 2011 Aug;32(8):1223-30. (PMID: 21622940) ; Anticancer Res. 2018 Apr;38(4):2087-2092. (PMID: 29599326) ; Pharmacogenomics. 2010 Oct;11(10):1377-87. (PMID: 21047201) ; Breast Cancer. 2020 Nov;27(6):1168-1176. (PMID: 32562189) ; Nutr Metab (Lond). 2020 Jan 31;17:12. (PMID: 32021640) ; Int J Hyg Environ Health. 2006 Jan;209(1):21-9. (PMID: 16373199) ; J Oral Pathol Med. 1995 Nov;24(10):450-3. (PMID: 8600280) ; Mol Cell. 1998 Aug;2(2):223-32. (PMID: 9734359) ; J Clin Lab Anal. 2020 Sep;34(9):e23403. (PMID: 32488882) Contributed Indexing: Keywords: Betel quid chewing; Taiwan; XPC; genotype; oral cancer; polymorphism; smoking Substance Nomenclature: 0 (DNA-Binding Proteins) ; 156533-34-5 (XPC protein, human) Entry Date(s): Date Created: 20210517 Date Completed: 20211108 Latest Revision: 20211108 Update Code: 20240513 PubMed Central ID: PMC8240044

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Interaction of DNA Repair Gene XPC With Smoking and Betel Quid Chewing Behaviors of Oral Cancer.