Insights into the Behavior of Triple-Negative MDA-MB-231 Breast Carcinoma Cells Following the Treatment with 17β-Ethinylestradiol and Levonorgestrel.
In: Molecules (Basel, Switzerland), Jg. 26 (2021-05-08), Heft 9
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Zugriff:
Oral contraceptives (OCs) are widely used due to their efficiency in preventing unplanned pregnancies and treating several human illnesses. Despite their medical value, the toxicity of OCs remains a public concern. Previous studies indicate the carcinogenic potential of synthetic sex hormones and their link to the development and progression of hormone-dependent malignancies such as breast cancer. However, little is known about their influence on the evolution of triple-negative breast carcinoma (TNBC), a malignancy defined by the absence of estrogen, progesterone, and HER2 receptors. This study reveals that the active ingredients of modern OCs, 17β-Ethinylestradiol, Levonorgestrel, and their combination induce differential effects in MDA-MB-231 TNBC cells. The most relevant behavioral changes occurred after the 24 h treatment with 17β-Ethinylestradiol, summarized as follows: (i) decreased cell viability (64.32% at 10 µM); (ii) cell roundness and loss of confluence; (iii) apoptotic aspect of cell nuclei (fragmentation, membrane blebbing); and (iv) inhibited cell migration, suggesting a potential anticancer effect. Conversely, Levonorgestrel was generally associated with a proliferative activity. The association of the two OCs exerted similar effects as 17β-Ethinylestradiol but was less effective. Further studies are necessary to elucidate the hormones' cytotoxic mechanism of action on TNBC cells.
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Insights into the Behavior of Triple-Negative MDA-MB-231 Breast Carcinoma Cells Following the Treatment with 17β-Ethinylestradiol and Levonorgestrel.
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Autor/in / Beteiligte Person: | Simu, S ; Marcovici, I ; Dobrescu, A ; Malita, D ; Dehelean, CA ; Coricovac, D ; Olaru, F ; Draghici, GA ; Navolan, D |
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Zeitschrift: | Molecules (Basel, Switzerland), Jg. 26 (2021-05-08), Heft 9 |
Veröffentlichung: | Basel, Switzerland : MDPI, c1995-, 2021 |
Medientyp: | academicJournal |
ISSN: | 1420-3049 (electronic) |
DOI: | 10.3390/molecules26092776 |
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