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CD8 positive, tissue resident memory T cells (T RM ) are a specialized subset of CD8 memory T cells that surveil tissues and provide critical first-line protection against tumors and pathogen re-infection. Recently, much effort has been dedicated to understanding the function, phenotype and development of T RM . A myriad of signals is involved in the development and maintenance of resident memory T cells in tissue. Much of the initial research focused on the roles tissue-derived signals play in the development of T RM , including TGFß and IL-33 which are critical for the upregulation of CD69 and CD103. However, more recent data suggest further roles for antigenic and pro-inflammatory cytokines. This review will focus on the interplay of pro-inflammatory, tissue and antigenic signals in the establishment of resident memory T cells.

Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Titel:	Interplay of Inflammatory, Antigen and Tissue-Derived Signals in the Development of Resident CD8 Memory T Cells.
Autor/in / Beteiligte Person:	Pritzl, CJ ; Daniels, MA ; Teixeiro, E
Link:	Full Text Finder (Volltext)
Zeitschrift:	Frontiers in immunology, Jg. 12 (2021-06-21), S. 636240
Veröffentlichung:	[Lausanne : Frontiers Research Foundation], 2021
Medientyp:	academicJournal
ISSN:	1664-3224 (electronic)
DOI:	10.3389/fimmu.2021.636240
Schlagwort:	Animals Antigens immunology CD8-Positive T-Lymphocytes immunology Humans Inflammation immunology Inflammation Mediators immunology Interleukin-33 immunology Interleukin-33 metabolism Interleukins immunology Phenotype Signal Transduction Transforming Growth Factor beta immunology Transforming Growth Factor beta metabolism Antigens metabolism CD8-Positive T-Lymphocytes metabolism Immunologic Memory Inflammation metabolism Inflammation Mediators metabolism Interleukins metabolism
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: English Publication Type: Journal Article; Research Support, N.I.H., Extramural; Review Language: English [Front Immunol] 2021 Jun 21; Vol. 12, pp. 636240. <i>Date of Electronic Publication: </i>2021 Jun 21 (<i>Print Publication: </i>2021). MeSH Terms: Immunologic Memory* ; Antigens / metabolism ; CD8-Positive T-Lymphocytes / metabolism ; Inflammation / metabolism ; Inflammation Mediators / metabolism ; Interleukins / *metabolism ; Animals ; Antigens / immunology ; CD8-Positive T-Lymphocytes / immunology ; Humans ; Inflammation / immunology ; Inflammation Mediators / immunology ; Interleukin-33 / immunology ; Interleukin-33 / metabolism ; Interleukins / immunology ; Phenotype ; Signal Transduction ; Transforming Growth Factor beta / immunology ; Transforming Growth Factor beta / metabolism References: J Immunol. 2014 Sep 1;193(5):2067-71. (PMID: 25070853) ; J Immunol. 2009 Mar 15;182(6):3380-9. 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Interplay of Inflammatory, Antigen and Tissue-Derived Signals in the Development of Resident CD8 Memory T Cells.