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Background/objectives: Validated pruritus-specific quality of life and self-reported severity instruments exist primarily for adults. Clinical trials to develop therapeutics for children with chronic pruritus are hampered by the paucity of appropriate outcome measures. To address this gap, we aimed to develop validated instruments to measure itch-specific quality of life and self-reported severity in children.

Methods: We conducted in-depth, open-ended interviews of itchy children and generated concepts to develop TweenItchyQoL. We administered TweenItchyQoL, ItchyQuant, a cartoon-annotated self-reported pruritus severity numeric rating scale (NRS), and a non-cartoon NRS to 175 itchy children aged 8-17 years. We analyzed the data for feasibility, preference, reliability, construct validity, and responsiveness.

Results: Average completion time was 4.8 minutes for TweenItchyQoL and 33 seconds for ItchyQuant. The majority of patients either preferred ItchyQuant or found no difference between ItchyQuant and the NRS. Cronbach's alpha for TweenItchyQoL total and subscales ranged from 0.84 to 0.95. Test-retest reliability coefficients were ≥0.7 for TweenItchyQoL and 0.4 for ItchyQuant. A 3-dimensional bifactor model was most appropriate (RMSEA = 0.048) on the confirmatory factor analyses. As a function of those reporting worsening, improvement, or no change at their final visit, TweenItchyQoL and ItchyQuant scores in those cohorts changed as expected.

Conclusions: This new set of validated and feasible instruments shows promise to quantify itch severity and QoL impact in older children.

Titel:	Tools to study the severity of itch in 8- to 17-year-old children: Validation of TweenItchyQoL and ItchyQuant.
Autor/in / Beteiligte Person:	Kong, HE ; Francois, S ; Smith, S ; Lee, G ; Bradley, B ; Chen, KH ; Lawley, LP ; Spraker, M ; Roberts, JS ; Chen, SC
Link:	Full Text Finder (Volltext)
Zeitschrift:	Pediatric dermatology, Jg. 38 (2021-09-01), Heft 5, S. 1118-1126
Veröffentlichung:	<2010->: Hoboken, NJ : Wiley ; <i>Original Publication</i>: [Boston, MA] : Blackwell Scientific Publications, [1983-, 2021
Medientyp:	academicJournal
ISSN:	1525-1470 (electronic)
DOI:	10.1111/pde.14662
Schlagwort:	Adolescent Adult Child Humans Reproducibility of Results Self Report Severity of Illness Index Surveys and Questionnaires Pruritus Quality of Life
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: English Publication Type: Journal Article Language: English [Pediatr Dermatol] 2021 Sep; Vol. 38 (5), pp. 1118-1126. <i>Date of Electronic Publication: </i>2021 Aug 02. MeSH Terms: Pruritus* ; Quality of Life* ; Adolescent ; Adult ; Child ; Humans ; Reproducibility of Results ; Self Report ; Severity of Illness Index ; Surveys and Questionnaires References: Metz M, Wahn U, Gieler U, Stock P, Schmitt J, Blume-Peytavi U. Chronic pruritus associated with dermatologic disease in infancy and childhood: Update from an interdisciplinary group of dermatologists and pediatricians. Pediatr Allergy Immunol. 2013;24(6):527-539. https://doi.org/10.1111/pai.12115. ; Williams H, Robertson C, Stewart A, et al. Worldwide variations in the prevalence of symptoms of atopic eczema in the international study of asthma and allergies in childhood. 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Grant Information: U01AR067169 United States AR NIAMS NIH HHS; U01AR067169 United States AR NIAMS NIH HHS Contributed Indexing: Keywords: pruritus; quality of life Entry Date(s): Date Created: 20210802 Date Completed: 20211110 Latest Revision: 20211110 Update Code: 20240513

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Tools to study the severity of itch in 8- to 17-year-old children: Validation of TweenItchyQoL and ItchyQuant.