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Objective: To assess the incidence of amyloidosis and trends therein in patients with spondyloarthritis (SpA) over a long period (17 years).

Methods: An observational retrospective population-based matched cohort study was conducted. All the admissions of patients with SpA, including ankylosing spondylitis (AS), psoriatic arthritis (PsA), arthritis associated with inflammatory bowel disease (SpA-IBD) and reactive arthritis (ReA), reported between 1999 and 2015, were analysed and a control group matched by age, sex and year of admission was selected. Incidence rates for amyloidosis were calculated. Generalised linear models were used for trend analysis and unconditional logistic regression for calculating crude and adjusted ORs (AOR) to assess the association between amyloidosis and SpA.

Results: The study database contained data on 107 140 admissions in each group. Between 1999 and 2015, 792 patients in the SpA cohort (0.7% of all admissions) had a diagnosis of amyloidosis versus 68 in the non-SpA cohort (0.1%) (p<0.001). From 1999 to 2015, incidence rates of amyloidosis tended to decrease in the SpA cohort (-4.63%/year overall), while they increased in the Non-SpA cohort (+10.25%/year overall). We found strong associations of amyloidosis with all SpAs (AOR 10.4; 95% CI 8.2 to 13.3) and with each type studied (AORs 10.05 (7.84 to 12. 88) for AS, 9.5 (7.3 to 12.4) for PsA, 22.9 (16.6 to 31.7) for SpA-IBD and 10.1 (6.1 to 16.7) for ReA).

Conclusions: Incidence of amyloidosis among patients with SpA has strongly decreased in Spain. Amyloidosis is most strongly associated with SpA-IBD while the strength of association with PsA and ReA is similar to that with AS.

Competing Interests: Competing interests: RM has received research grants from Pfizer, Roche and Amgen for other projects.

Titel:	Trends in amyloidosis in spondyloarthritis: results from the Spanish National Inpatient Registry over a 17-year period (1999-2015)-TREND-EspA study.
Autor/in / Beteiligte Person:	Mazzucchelli, R ; Almodovar-González, R ; Dieguez-Costa, E ; Crespí-Villarías, N ; Pérez-Fernández, E ; García-Zamora, E ; Garcia Vadillo, A
Link:	Full Text Finder (Volltext)
Zeitschrift:	RMD open, Jg. 7 (2021-09-01), Heft 3
Veröffentlichung:	London : BMJ Publishing Group, [2015]-, 2021
Medientyp:	academicJournal
ISSN:	2056-5933 (electronic)
DOI:	10.1136/rmdopen-2021-001782
Schlagwort:	Cohort Studies Humans Inpatients Prohibitins Registries Retrospective Studies Amyloidosis epidemiology Spondylarthritis diagnosis Spondylarthritis epidemiology
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: English Publication Type: Journal Article; Observational Study; Research Support, Non-U.S. Gov't Language: English [RMD Open] 2021 Sep; Vol. 7 (3). MeSH Terms: Amyloidosis* / epidemiology ; Spondylarthritis* / diagnosis ; Spondylarthritis* / epidemiology ; Cohort Studies ; Humans ; Inpatients ; Prohibitins ; Registries ; Retrospective Studies References: Eur J Clin Invest. 2013 Aug;43(8):767-73. (PMID: 23683125) ; Clin Epidemiol. 2014 Oct 29;6:369-77. (PMID: 25378951) ; Br J Haematol. 2013 May;161(4):525-32. (PMID: 23480608) ; N Engl J Med. 2007 Jun 7;356(23):2361-71. (PMID: 17554117) ; Eur J Intern Med. 2017 Apr;39:e18-e20. (PMID: 28214252) ; An Bras Dermatol. 2021 May-Jun;96(3):324-327. (PMID: 33781647) ; Med Care. 2018 Sep;56(9):812-813. (PMID: 30059362) ; Amyloid. 2020 Mar;27(1):1-12. (PMID: 31766892) ; Clin Rheumatol. 1999;18(2):122-3. (PMID: 10357116) ; Rev Clin Esp. 1977 Nov 30;147(4):349-54. (PMID: 601292) ; Scand J Rheumatol. 2010 Nov;39(6):461-5. (PMID: 20560815) ; Rheumatology (Oxford). 2020 Oct 1;59(Suppl4):iv38-iv46. (PMID: 33053194) ; Reumatol Clin (Engl Ed). 2019 Mar - Apr;15(2):90-96. (PMID: 28774657) ; BMJ. 2003 Jan 25;326(7382):219. (PMID: 12543843) ; Amyloid. 2017 Sep;24(3):162-166. (PMID: 28686088) ; Amyloid. 2016 Sep;23(3):184-187. (PMID: 27470486) ; Lancet. 2011 Jun 18;377(9783):2127-37. (PMID: 21684383) ; Osteoporos Int. 2018 Oct;29(10):2231-2241. (PMID: 30094608) ; Health Policy. 2014 Jan;114(1):15-30. (PMID: 24035101) ; PLoS One. 2019 May 17;14(5):e0217005. (PMID: 31100086) ; Rheum Dis Clin North Am. 2018 Nov;44(4):585-603. (PMID: 30274625) ; Rev Clin Esp (Barc). 2013 May;213(4):186-93. (PMID: 23246354) ; Amyloid. 2018 Mar;25(1):37-45. (PMID: 29364741) ; Baillieres Clin Rheumatol. 1994 Aug;8(3):627-34. (PMID: 7954866) ; N Engl J Med. 2020 Apr 16;382(16):1567-1568. (PMID: 32294353) ; Nat Rev Dis Primers. 2015 Jul 09;1:15013. (PMID: 27188328) ; Amyloid. 2011 Jun;18 Suppl 1:6-7. (PMID: 21838413) ; Rheumatol Int. 2013 Jul;33(7):1725-9. (PMID: 23283540) ; J Rheumatol. 2007 Feb;34(2):371-3. (PMID: 17295439) ; Saudi J Kidney Dis Transpl. 2018 Mar-Apr;29(2):386-391. (PMID: 29657208) Contributed Indexing: Keywords: amyloidosis; epidemiology; spondyloarthritis Entry Date(s): Date Created: 20211001 Date Completed: 20211101 Latest Revision: 20211204 Update Code: 20240513 PubMed Central ID: PMC8487213

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Trends in amyloidosis in spondyloarthritis: results from the Spanish National Inpatient Registry over a 17-year period (1999-2015)-TREND-EspA study.