Heightened Local T <subscript>h</subscript> 17 Cell Inflammation Is Associated with Severe Community-Acquired Pneumonia in Children under the Age of 1 Year.
In: Mediators of inflammation, Jg. 2021 (2021-09-22), S. 9955168
Online
academicJournal
Zugriff:
Severe community-acquired pneumonia (sCAP) early in life is a leading cause of morbidity, mortality, and irreversible sequelae. Herein, we report the clinical, etiological, and immunological characteristics of 62 children age < 1 year. We measured 27 cytokines in plasma and bronchoalveolar lavage (BAL) from 62 children age < 1 year who were diagnosed with CAP, and then, we analyzed correlations among disease severity, clinical parameters, and etiology. Of the entire cohort, three cytokines associated with interleukin-17- (IL-17-) producing helper T cells (T h 17 cells), IL-1 β , IL-6, and IL-17, were significantly elevated in sCAP patients with high fold changes (FCs); in BAL, these cytokines were intercorrelated and associated with blood neutrophil counts, Hb levels, and mixed bacterial-viral infections. BAL IL-1 β (area under the curve (AUC) 0.820), BAL IL-17 (AUC 0.779), and plasma IL-6 (AUC 0.778) had remarkable predictive power for sCAP. Our findings revealed that increased local T h 17 cell immunity played a critical role in the development of sCAP in children age < 1 year. T h 17 cell-related cytokines could serve as local and systemic inflammatory indicators of sCAP in this age group.
Competing Interests: All authors report no conflicts of interest.
(Copyright © 2021 Ming Liu et al.)
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Heightened Local T <subscript>h</subscript> 17 Cell Inflammation Is Associated with Severe Community-Acquired Pneumonia in Children under the Age of 1 Year.
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Autor/in / Beteiligte Person: | Liu, M ; Lu, B ; Fan, H ; Guo, X ; Du, S ; Yang, D ; Xu, Y ; Li, Y ; Che, D ; Liu, Y ; Gu, X ; Ding, T ; Wang, P ; Luo, HB ; Lu, G |
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Zeitschrift: | Mediators of inflammation, Jg. 2021 (2021-09-22), S. 9955168 |
Veröffentlichung: | 2005- : Sylvania, OH : Hindawi Pub. Corp. ; <i>Original Publication</i>: Oxford, UK : Rapid Communications of Oxford Ltd., c1992-, 2021 |
Medientyp: | academicJournal |
ISSN: | 1466-1861 (electronic) |
DOI: | 10.1155/2021/9955168 |
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