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Background: The role of circadian rhythm abnormalities in patients with inflammatory bowel disease (IBD) remains relatively unknown. The aim of this study was to identify the inflammatory cytokine profile in the IBD patients and its relationship with the quality of sleep.

Methods: Prospective, single-center observational cohort study was performed. In all enrolled adult IBD patients, the disease activity was assessed using Crohn's Disease Activity Index (CDAI) for Crohn's disease (CD) and Partial Mayo Score for ulcerative colitis (UC), respectively. To assess the quality of sleep, all patients were asked to respond to a questionnaire to define Pittsburgh Quality Sleep Index (PSQI). From all enrolled patients, 15 ml venous blood was taken to determine serum inflammatory cytokine levels and perform standard laboratory tests.

Results: Fifty-two IBD patients were enrolled in the study: 32 with CD and 20 with UC. The poor sleep was noted in 69.4% of patients with clinically active and in 6.3% of patients with inactive disease. In the group of IBD patients with poor sleep, the significantly higher level of serum IL-6, IL-17, and IL-23 were observed. In IBD patients with exacerbation, the significantly higher level of serum IL-6, IL-17, and IL-23 were recorded.

Conclusions: The relationship between quality of sleep and proinflammatory cytokine profile may show us a predisposition for the development of inflammatory intestinal lesions in IBD patients with sleep disturbances. This knowledge may allow the pharmacological and behavioral therapies of circadian rhythm abnormalities to become new significant targets in IBD patients.

Titel:	The association of the quality of sleep with proinflammatory cytokine profile in inflammatory bowel disease patients.
Autor/in / Beteiligte Person:	Sobolewska-Włodarczyk, A ; Włodarczyk, M ; Talar, M ; Wiśniewska-Jarosińska, M ; Gąsiorowska, A ; Fichna, J
Link:	Full Text Finder (Volltext)
Zeitschrift:	Pharmacological reports : PR, Jg. 73 (2021-12-01), Heft 6, S. 1660-1669
Veröffentlichung:	2020- : Cham, Switzerland : Springer International Publishing ; <i>Original Publication</i>: Kraków, Poland : Institute of Pharmacology, Polish Academy of Sciences, c2005-, 2021
Medientyp:	academicJournal
ISSN:	2299-5684 (electronic)
DOI:	10.1007/s43440-021-00333-0
Schlagwort:	Adult Cohort Studies Female Humans Inflammation Mediators blood Male Middle Aged Prospective Studies Severity of Illness Index Sleep Quality Surveys and Questionnaires Young Adult Colitis, Ulcerative physiopathology Crohn Disease physiopathology Cytokines blood Sleep Wake Disorders epidemiology
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: English Publication Type: Journal Article; Observational Study Language: English [Pharmacol Rep] 2021 Dec; Vol. 73 (6), pp. 1660-1669. <i>Date of Electronic Publication: </i>2021 Oct 25. MeSH Terms: Colitis, Ulcerative / physiopathology ; Crohn Disease / physiopathology ; Cytokines / blood ; Sleep Wake Disorders / epidemiology ; Adult ; Cohort Studies ; Female ; Humans ; Inflammation Mediators / blood ; Male ; Middle Aged ; Prospective Studies ; Severity of Illness Index ; Sleep Quality ; Surveys and Questionnaires ; Young Adult References: Transl Res. 2019 Apr;206:107-118. (PMID: 30615844) ; J Physiol Pharmacol. 2018 Jun;69(3):. (PMID: 30279306) ; Psychiatry Res. 1989 May;28(2):193-213. (PMID: 2748771) ; J Clin Sleep Med. 2021 Oct 06;:. (PMID: 34609276) ; Gut. 2002 Jul;51(1):37-43. (PMID: 12077089) ; Psychosom Med. 1995 Mar-Apr;57(2):97-104. (PMID: 7792381) ; Gut. 2013 Apr;62(4):630-49. (PMID: 23335431) ; Gastroenterology. 2011 Mar;140(3):957-65. (PMID: 21147109) ; J Infect Dis. 1997 Aug;176(2):439-44. (PMID: 9237710) ; Inflamm Bowel Dis. 2013 Oct;19(11):2440-3. (PMID: 23945186) ; Nat Rev Immunol. 2019 Nov;19(11):702-715. (PMID: 31289370) ; Pharmacol Rep. 2016 Aug;68(4):847-51. (PMID: 27166084) ; Am J Physiol Regul Integr Comp Physiol. 2008 Dec;295(6):R2034-40. (PMID: 18843092) ; Clin Gastroenterol Hepatol. 2013 Aug;11(8):965-71. (PMID: 23376797) ; Sleep Med Rev. 1999 Sep;3(3):219-28. (PMID: 15310476) ; Physiol Rev. 2019 Jul 1;99(3):1325-1380. (PMID: 30920354) ; Sleep Med Rev. 2005 Oct;9(5):355-64. (PMID: 16102986) ; Curr Opin Immunol. 2012 Dec;24(6):651-7. (PMID: 23131610) ; Gastroenterol Hepatol (N Y). 2013 Nov;9(11):718-27. (PMID: 24764789) ; N Engl J Med. 2011 Dec 8;365(23):2205-19. (PMID: 22150039) ; Curr Gastroenterol Rep. 2013 Jan;15(1):302. (PMID: 23250702) ; Dig Dis Sci. 2003 Apr;48(4):743-9. (PMID: 12741465) ; J Clin Sleep Med. 2006 Oct 15;2(4):409-16. (PMID: 17557469) ; Semin Clin Neuropsychiatry. 2001 Oct;6(4):295-307. (PMID: 11607924) ; Inflamm Res. 2007 Feb;56(2):51-7. (PMID: 17431741) ; Dermatol Clin. 2013 Jul;31(3):445-60. (PMID: 23827247) ; Prog Cardiovasc Nurs. 2004 Spring;19(2):56-9. (PMID: 15133379) ; Inflamm Bowel Dis. 2011 Sep;17(9):1882-9. (PMID: 21830266) ; J Gastroenterol. 2012 Jul;47(7):760-9. (PMID: 22592763) ; JAMA. 2008 Dec 24;300(24):2859-66. (PMID: 19109114) ; Health Qual Life Outcomes. 2012 Jun 18;10:72. (PMID: 22709334) ; Neurol Clin. 2012 Nov;30(4):1313-43. (PMID: 23099140) ; Sleep. 2007 Sep;30(9):1145-52. (PMID: 17910386) Grant Information: 2015/17/N/NZ5/00677 Narodowe Centrum Nauki; 503/1-156-04/503-11-001 Uniwersytet Medyczny w Lodzi Contributed Indexing: Keywords: Circadian rhythm abnormalities; Crohn’s disease; Inflammatory bowel diseases; Quality of sleep; Ulcerative colitis Substance Nomenclature: 0 (Cytokines) ; 0 (Inflammation Mediators) Entry Date(s): Date Created: 20211025 Date Completed: 20220208 Latest Revision: 20220218 Update Code: 20240513 PubMed Central ID: PMC8599325

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The association of the quality of sleep with proinflammatory cytokine profile in inflammatory bowel disease patients.