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The brain targeted delivery of programmed cell death 4 specific siRNA protects mice from CRS-induced depressive behavior.
In: Cell death & disease, Jg. 12 (2021-11-12), Heft 11, S. 1077
Online
academicJournal
Zugriff:
Depression is one of the most common psychiatric disorders. Recently, studies demonstrate that antidepressants generating BDNF not only maintain synaptic signal transmission but also repress neuroinflammatory cytokines such as IL-6 and IL-1β. Therefore, promoting BDNF expression provides a strategy for the treatment of depression. Our recent research has indicated that programmed cell death 4 (Pdcd4) is a new target for antidepressant treatment by facilitating BDNF. Herein, we modified Pdcd4 specific small interfering RNA (siPdcd4) with the rabies virus glycoprotein peptide (RVG/siPdcd4) which enables it cross the blood-brain barrier (BBB). We found that RVG/siPdcd4 complex was selectively delivered to neurons and microglia and silenced the expression of Pdcd4, thereby up-regulating the level of BDNF and down-regulating IL-6 and IL-1β expression. More importantly, RVG/siPdcd4 injection attenuated synaptic plasticity impairment and protected mice from CRS-induced depressive behavior. These findings suggest that RVG/siPdcd4 complex is a potential therapeutic medicine for depression.
(© 2021. The Author(s).)
| Titel: |
The brain targeted delivery of programmed cell death 4 specific siRNA protects mice from CRS-induced depressive behavior.
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| Autor/in / Beteiligte Person: | Jia, Y ; Zhuang, X ; Zhang, Y ; Zhao, M ; Chen, N ; Li, W ; Zhu, F ; Guo, C ; Li, Y ; Wang, Q ; Zhang, L |
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| Zeitschrift: | Cell death & disease, Jg. 12 (2021-11-12), Heft 11, S. 1077 |
| Veröffentlichung: | London : Nature Pub. Group, 2021 |
| Medientyp: | academicJournal |
| ISSN: | 2041-4889 (electronic) |
| DOI: | 10.1038/s41419-021-04361-9 |
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