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Moving the Research Forward: The Best of British Biology Using the Tractable Model System Dictyostelium discoideum .

Williams, RSB ; Chubb, JR ; et al.
In: Cells, Jg. 10 (2021-11-05), Heft 11
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The social amoeba Dictyostelium discoideum provides an excellent model for research across a broad range of disciplines within biology. The organism diverged from the plant, yeast, fungi and animal kingdoms around 1 billion years ago but retains common aspects found in these kingdoms. Dictyostelium has a low level of genetic complexity and provides a range of molecular, cellular, biochemical and developmental biology experimental techniques, enabling multidisciplinary studies to be carried out in a wide range of areas, leading to research breakthroughs. Numerous laboratories within the United Kingdom employ Dictyostelium as their core research model. This review introduces Dictyostelium and then highlights research from several leading British research laboratories, covering their distinct areas of research, the benefits of using the model, and the breakthroughs that have arisen due to the use of Dictyostelium as a tractable model system.

Titel:
Moving the Research Forward: The Best of British Biology Using the Tractable Model System Dictyostelium discoideum .
Autor/in / Beteiligte Person: Williams, RSB ; Chubb, JR ; Insall, R ; King, JS ; Pears, CJ ; Thompson, E ; Weijer, CJ
Link:
Zeitschrift: Cells, Jg. 10 (2021-11-05), Heft 11
Veröffentlichung: Basel, Switzerland : MDPI, 2021
Medientyp: academicJournal
ISSN: 2073-4409 (electronic)
DOI: 10.3390/cells10113036
Schlagwort:
  • Animals
  • Dictyostelium cytology
  • Drug Discovery
  • Protein Processing, Post-Translational
  • United Kingdom
  • Biology
  • Dictyostelium physiology
  • Models, Biological
  • Research
Sonstiges:
  • Nachgewiesen in: MEDLINE
  • Sprachen: English
  • Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Review
  • Language: English
  • [Cells] 2021 Nov 05; Vol. 10 (11). <i>Date of Electronic Publication: </i>2021 Nov 05.
  • MeSH Terms: Biology* ; Models, Biological* ; Research* ; Dictyostelium / *physiology ; Animals ; Dictyostelium / cytology ; Drug Discovery ; Protein Processing, Post-Translational ; United Kingdom
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  • Grant Information: MR/P028284/1 United Kingdom MRC_ Medical Research Council; NC/K500355/1 United Kingdom NC3RS_ National Centre for the Replacement, Refinement and Reduction of Animals in Research; BB/K017004/1 United Kingdom BB_ Biotechnology and Biological Sciences Research Council; 202867/Z/16/Z United Kingdom WT_ Wellcome Trust; NC/M000834/1 United Kingdom NC3RS_ National Centre for the Replacement, Refinement and Reduction of Animals in Research
  • Contributed Indexing: Keywords: Dictyostelium discoideum; autophagy; chemotaxis; development; macropinocytosis; phagocytosis; slime mould; social amoeba
  • Entry Date(s): Date Created: 20211127 Date Completed: 20211221 Latest Revision: 20240214
  • Update Code: 20240214
  • PubMed Central ID: PMC8616412

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