Quantification of H <subscript>2</subscript> <superscript>17</superscript> O by <superscript>1</superscript> H-MR imaging at 3 T: a feasibility study.
In: European radiology experimental, Jg. 5 (2021-12-29), Heft 1, S. 56
Online
academicJournal
Zugriff:
Background: Indirect 1 H-magnetic resonance (MR) imaging of 17 O-labelled water allows imaging in vivo dynamic changes in water compartmentalisation. Our aim was to describe the feasibility of indirect 1 H-MR methods to evaluate the effect of H 2 17 O on the MR relaxation rates by using conventional a 3-T equipment and voxel-wise relaxation rates.
Methods: MR images were used to calculate the R1, R2, and R2* relaxation rates in phantoms (19 vials with different H 2 17 O concentrations, ranging from 0.039 to 5.5%). Afterwards, an experimental animal pilot study (8 rats) was designed to evaluate the in vivo relative R2 brain dynamic changes related to the intravenous administration of 17 O-labelled water in rats.
Results: There were no significant changes on the R1 and R2* values from phantoms. The R2 obtained with the turbo spin-echo T2-weighted sequence with 20-ms echo time interval had the higher statistical difference (0.67 s -1 , interquartile range 0.34, p < 0.001) and Spearman correlation (rho 0.79). The R2 increase was adjusted to a linear fit between 0.25 and 5.5%, represented with equation R2 = 0.405 concentration + 0.3215. The highest significant differences were obtained for the higher concentrations (3.1-5.5%). The rat brain MR experiment showed a mean 10% change in the R2 value after the H 2 17 O injection with progressive normalisation.
Conclusions: Indirect 1 H-MR imaging method is able to measure H 2 17 O concentration by using R2 values and conventional 3-T MR equipment. Normalised R2 relative dynamic changes after the intravenous injection of a H 2 17 O saline solution provide a unique opportunity to map water pathophysiology in vivo, opening the analysis of aquaporins status and modifications by disease at clinically available 3-T proton MR scanners.
(© 2021. The Author(s).)
Titel: |
Quantification of H <subscript>2</subscript> <superscript>17</superscript> O by <superscript>1</superscript> H-MR imaging at 3 T: a feasibility study.
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Autor/in / Beteiligte Person: | Martí-Bonmatí, L ; Rodríguez-Ortega, A ; Ten-Esteve, A ; Alberich-Bayarri, Á ; Celda, B ; Ferrer, E |
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Zeitschrift: | European radiology experimental, Jg. 5 (2021-12-29), Heft 1, S. 56 |
Veröffentlichung: | [London, United Kingdom] : SpringerOpen, [2017]-, 2021 |
Medientyp: | academicJournal |
ISSN: | 2509-9280 (electronic) |
DOI: | 10.1186/s41747-021-00246-w |
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