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Dengue viral (DENV) infections can lead to acute pancreatitis and associated tissue damage. This study examined the pancreas from two fatal cases of DENV for histopathological changes as well as for the detection of cytokines, and other inflammatory mediators. Tissue sections were prepared for examination by ultrastructural and histopathological techniques. Sections from the pancreas of non-infected individuals were prepared in parallel as a control. The presence of viral replication in macrophages was detected by co-staining for the proteins NS3 and CD68 by immunofluorescence. Immunohistochemistry was used to detect cells that expressed cytokines and inflammatory mediators to characterize the inflammatory response. Edema, acinar necrosis and fibrosis areas associated with a mononuclear infiltrate were found in infected tissues. The major site of virus replication appeared to be macrophages based on their exclusive presentation of the viral protein NS3. Pancreatic tissues from the infected individuals also displayed increased levels of high mobility group box-1, caspase-3, gelatinase B and tumor necrosis factor alpha compared to controls. The presence of virus replicating macrophages in the pancreas was associated with multiple changes in tissue structure that included elevated levels of cytokines and inflammatory markers that may differentiate acute pancreatitis due to DENV infections from other causes.

Competing Interests: The authors have declared that no competing interests exist.

Titel:	Cytokines and inflammatory mediators: Markers involved in interstitial damage to the pancreas in two dengue fever cases associated with acute pancreatitis.
Autor/in / Beteiligte Person:	Alves, FAV ; Oliveira, LLS ; Salomão, NG ; Provance DW Jr ; Basilio-de-Oliveira, CA ; Basílio-de-Oliveira, R ; Moragas, LJ ; de Carvalho JJ ; Mohana-Borges, R ; Rabelo, K ; Paes, MV
Link:	Full Text Finder (Volltext)
Zeitschrift:	PloS one, Jg. 17 (2022-01-18), Heft 1, S. e0262785
Veröffentlichung:	San Francisco, CA : Public Library of Science, 2022
Medientyp:	academicJournal
ISSN:	1932-6203 (electronic)
DOI:	10.1371/journal.pone.0262785
Schlagwort:	Adult Apoptosis Dengue virology Female Humans Male Middle Aged Pancreatitis metabolism Pancreatitis virology Young Adult Biomarkers metabolism Cytokines metabolism Dengue complications Dengue Virus isolation & purification Inflammation Mediators metabolism Pancreatitis pathology
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: English Publication Type: Case Reports; Journal Article; Research Support, Non-U.S. Gov't Language: English [PLoS One] 2022 Jan 18; Vol. 17 (1), pp. e0262785. <i>Date of Electronic Publication: </i>2022 Jan 18 (<i>Print Publication: </i>2022). MeSH Terms: Biomarkers / metabolism ; Cytokines / metabolism ; Dengue / complications ; Dengue Virus / isolation & purification ; Inflammation Mediators / metabolism ; Pancreatitis / pathology ; Adult ; Apoptosis ; Dengue / virology ; Female ; Humans ; Male ; Middle Aged ; Pancreatitis / metabolism ; Pancreatitis / virology ; Young Adult References: Virchows Arch A Pathol Anat Histopathol. 1989;415(2):115-23. (PMID: 2500766) ; J Clin Invest. 1997 Oct 1;100(7):1853-62. (PMID: 9312187) ; Pancreas. 2007 Nov;35(4):376-8. (PMID: 18090247) ; Indian J Pediatr. 2018 Apr;85(4):318-319. (PMID: 29076099) ; J Gastroenterol. 2009;44(4):249-60. (PMID: 19271115) ; Front Immunol. 2020 Sep 01;11:2146. (PMID: 32983175) ; Arch Med Res. 2018 Oct;49(7):504-511. (PMID: 30947809) ; J Hepatobiliary Pancreat Surg. 2006;13(1):25-32. (PMID: 16463208) ; Cureus. 2019 Jun 13;11(6):e4895. (PMID: 31423374) ; Biofactors. 2011 Jul-Aug;37(4):323-7. (PMID: 21915938) ; Front Immunol. 2017 Dec 07;8:1704. (PMID: 29270171) ; PLoS One. 2016 Dec 22;11(12):e0168973. (PMID: 28006034) ; ANZ J Surg. 2006 Sep;76(9):801-4. (PMID: 16922902) ; Nat Rev Gastroenterol Hepatol. 2019 Aug;16(8):479-496. (PMID: 31138897) ; J Histochem Cytochem. 2014 Dec;62(12):902-6. (PMID: 25216937) ; Dig Dis Sci. 1992 Sep;37(9):1426-33. (PMID: 1380425) ; Proc Natl Acad Sci U S A. 2010 Oct 5;107(40):17345-50. (PMID: 20855599) ; Pancreatology. 2012 May-Jun;12(3):234-9. (PMID: 22687379) ; Prog Mol Biol Transl Sci. 2017;147:1-73. (PMID: 28413025) ; Clin J Gastroenterol. 2016 Feb;9(1):7-12. (PMID: 26864047) ; Lab Invest. 2004 Dec;84(12):1610-8. (PMID: 15502860) ; Am J Physiol. 1998 Dec;275(6):G1402-14. (PMID: 9843778) ; Lancet. 2015 Jan 31;385(9966):453-65. (PMID: 25230594) ; Tohoku J Exp Med. 2006 Jun;209(2):99-107. (PMID: 16707851) ; World J Gastrointest Pharmacol Ther. 2010 Oct 6;1(5):107-11. (PMID: 21577304) ; Infect Disord Drug Targets. 2010 Feb;10(1):2-4. (PMID: 20180751) ; J Glob Infect Dis. 2014 Apr;6(2):76-8. (PMID: 24926168) ; Annu Rev Microbiol. 1990;44:649-88. (PMID: 2174669) ; Am J Gastroenterol. 2013 Sep;108(9):1400-15; 1416. (PMID: 23896955) ; Am J Pathol. 2002 May;160(5):1787-98. (PMID: 12000730) ; FEBS Lett. 2020 Aug;594(16):2543-2555. (PMID: 31943152) ; Trends Immunol. 2004 May;25(5):222-9. (PMID: 15099561) ; Curr Opin Gastroenterol. 2015 Sep;31(5):395-9. (PMID: 26107390) ; J Infect Dis. 2004 Apr 15;189(8):1411-8. (PMID: 15073678) ; J Hepatobiliary Pancreat Surg. 2002;9(4):401-10. (PMID: 12483260) ; Science. 2006 Feb 10;311(5762):847-51. (PMID: 16469926) ; J Leukoc Biol. 2004 Jun;75(6):1086-92. (PMID: 14982951) ; Emerg Microbes Infect. 2018 Oct 10;7(1):167. (PMID: 30301880) ; Acta Pathol Microbiol Immunol Scand A. 1982 Sep;90(5):367-73. (PMID: 7148455) ; Int J Gastrointest Cancer. 2002;31(1-3):41-6. (PMID: 12622414) ; Gastroenterology. 1996 Feb;110(2):576-82. (PMID: 8566606) ; J Clin Diagn Res. 2014 Jan;8(1):71-3. (PMID: 24596727) ; Radiol Clin North Am. 2015 Nov;53(6):1189-208. (PMID: 26526433) ; Indian J Gastroenterol. 2008 Jul-Aug;27(4):162-4. (PMID: 18974468) ; Front Cell Infect Microbiol. 2017 Jul 12;7:317. (PMID: 28748176) ; World J Gastroenterol. 2013 Sep 21;19(35):5798-805. (PMID: 24124324) ; Development. 1994 Dec;120(12):3451-62. (PMID: 7821214) ; Virology. 2008 Dec 5;382(1):20-7. (PMID: 18929380) ; Rev Soc Bras Med Trop. 2016 Sep-Oct;49(5):656-659. (PMID: 27812667) ; Stroke. 2010 Sep;41(9):2077-82. (PMID: 20671243) ; Differentiation. 2000 May;65(5):255-9. (PMID: 10929204) ; PLoS One. 2014 Apr 15;9(4):e83386. (PMID: 24736395) ; J Immunol. 2003 Nov 15;171(10):5579-86. (PMID: 14607966) ; Gastroenterol Clin North Am. 2007 Jun;36(2):277-96, viii. (PMID: 17533079) ; JOP. 2007 Sep 07;8(5):564-72. (PMID: 17873460) ; Int J Mol Med. 2016 Jan;37(1):99-107. (PMID: 26719855) ; Gut. 2000 Oct;47(4):546-52. (PMID: 10986216) ; Sci Rep. 2017 Nov 22;7(1):16011. (PMID: 29167501) ; Nature. 2002 Jul 11;418(6894):191-5. (PMID: 12110890) ; J Leukoc Biol. 2000 Nov;68(5):737-47. (PMID: 11073115) ; Gastroenterology Res. 2017 Jun;10(3):153-158. (PMID: 28725301) ; J Gen Virol. 2009 Aug;90(Pt 8):1827-1835. (PMID: 19369409) Substance Nomenclature: 0 (Biomarkers) ; 0 (Cytokines) ; 0 (Inflammation Mediators) Entry Date(s): Date Created: 20220118 Date Completed: 20220221 Latest Revision: 20231102 Update Code: 20240513 PubMed Central ID: PMC8765625

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Cytokines and inflammatory mediators: Markers involved in interstitial damage to the pancreas in two dengue fever cases associated with acute pancreatitis.