A single factor elicits multilineage reprogramming of astrocytes in the adult mouse striatum.
In: Proceedings of the National Academy of Sciences of the United States of America, Jg. 119 (2022-03-15), Heft 11, S. e2107339119
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academicJournal
Zugriff:
SignificanceOutside the neurogenic niches, the adult brain lacks multipotent progenitor cells. In this study, we performed a series of in vivo screens and reveal that a single factor can induce resident brain astrocytes to become induced neural progenitor cells (iNPCs), which then generate neurons, astrocytes, and oligodendrocytes. Such a conclusion is supported by single-cell RNA sequencing and multiple lineage-tracing experiments. Our discovery of iNPCs is fundamentally important for regenerative medicine since neural injuries or degeneration often lead to loss/dysfunction of all three neural lineages. Our findings also provide insights into cell plasticity in the adult mammalian brain, which has largely lost the regenerative capacity.
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A single factor elicits multilineage reprogramming of astrocytes in the adult mouse striatum.
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Autor/in / Beteiligte Person: | Zhang, Y ; Li, B ; Cananzi, S ; Han, C ; Wang, LL ; Zou, Y ; Fu, YX ; Hon, GC ; Zhang, CL |
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Zeitschrift: | Proceedings of the National Academy of Sciences of the United States of America, Jg. 119 (2022-03-15), Heft 11, S. e2107339119 |
Veröffentlichung: | Washington, DC : National Academy of Sciences, 2022 |
Medientyp: | academicJournal |
ISSN: | 1091-6490 (electronic) |
DOI: | 10.1073/pnas.2107339119 |
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