Red blood cell distribution width-to-albumin ratio is associated with all-cause mortality in cancer patients.
In: Journal of clinical laboratory analysis, Jg. 36 (2022-05-01), Heft 5, S. e24423
Online
academicJournal
Zugriff:
Background: Cancer causes a serious health burden on patients worldwide. Chronic low-level inflammation plays a key role in tumorigenesis and prognosis. However, the role of the red blood cell distribution width (RDW)-to-albumin (RA) ratio in cancer mortality remains unclear.
Methods: In this retrospective cohort study, we collected clinical information from cancer patients from the Medical Information Mart for Intensive Care III (MIMIC-III) version 1.4 database and then calculated RA by dividing RDW by albumin concentration. The primary outcome was 30 days mortality, while secondary outcomes were 90 days and 1 year mortality. Next, we adopted Cox regression models to calculate hazard ratios (HR) together with 95% confidence intervals (CI) for all-cause mortalities associated with the RA ratio.
Results: For 30 days mortality, the HR (95% CI) for the high RA ratio (≥5.51) was 2.17 [95CI% (1.87-2.51); p = <0.0001], compared with the low RA ratio (<5.51). In Model 2, we adjusted sex and age and obtained HR (95% CI) of 2.17 [95CI% (1.87-2.52); p = <0.0001] for the high RA ratio (≥5.51) group, compared to that in the low RA ratio (<5.51). In Model 3, adjusting for age, sex, anion gap, hematocrit, white blood cell count, congestive heart failure, SOFA, liver disease, and renal failure resulted in HR (95% CI) of 1.74 [95CI% (1.48-2.04); p = <0.0001] for the high RA ratio (≥5.51) relative to the low RA ratio (<5.51). We also analyzed common diseases in cancer patients but found no significant association.
Conclusion: To the best of our knowledge, this is the first study demonstrating that increased RA ratio is independently associated with increased all-cause mortality in cancer patients.
(© 2022 The Authors. Journal of Clinical Laboratory Analysis published by Wiley Periodicals LLC.)
| Titel: |
Red blood cell distribution width-to-albumin ratio is associated with all-cause mortality in cancer patients.
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| Autor/in / Beteiligte Person: | Lu, C ; Long, J ; Liu, H ; Xie, X ; Xu, D ; Fang, X ; Zhu, Y |
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| Zeitschrift: | Journal of clinical laboratory analysis, Jg. 36 (2022-05-01), Heft 5, S. e24423 |
| Veröffentlichung: | Hoboken, N.J. : Wiley ; <i>Original Publication</i>: New York : Alan R. Liss, Inc., c1987-, 2022 |
| Medientyp: | academicJournal |
| ISSN: | 1098-2825 (electronic) |
| DOI: | 10.1002/jcla.24423 |
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