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Human oral squamous cell carcinoma (OSCC) has been one of the most common oral cancers owing to high percentage of betel nuts chewers, smokers, and alcohol consumption. With current treatment strategies in OSCC, more than half patients relapse and develop distant metastases with poor prognosis. To overcome the incident, OSCC poses a challenge in current therapies and treatments. Naringenin, a natural flavonoid, has been noted for antitumor effects on various types of cancers; however, the effects of naringenin on OSCC remain bias. In this study, naringenin demonstrated the potential multifunction in human OSCC cells not only leading to cell apoptosis, but also alternating the general function of autophagy, serving as pro-survival mechanism by inducing the endoplasmic reticulum (ER) stress signaling through intracellular reactive oxygen species (ROS) production. In the process of programmed cell death, naringenin induced apoptotic signaling through caspase-cascade, mitochondrial dysfunction, and ER stress by aberrance of Ca 2+ release. In contrast, under the presence of naringenin, the pro-survival has been altered into pro-death to activate the caspases-mediated apoptosis achieving cell death. The cross-function of apoptosis and autophagy has demonstrated the effect of naringenin-induced intracellular ROS activity in OSCC cells. Therefore, this study found that the effect of naringenin induces intracellular ROS to trigger programmed cell death and ER stress through the mechanisms of apoptosis and autophagy in human oral squamous carcinoma. PRACTICAL APPLICATIONS: This study revealed that naringenin debilitated the OSCC cell viability via the intracellular ROS production, ER stress, and autophagy, leading to cell apoptosis. Based on these studies and findings, naringenin provided an antitumor effect as a novel natural compound to improve the current therapies in OSCC.

Titel:	Naringenin induces endoplasmic reticulum stress-mediated cell apoptosis and autophagy in human oral squamous cell carcinoma cells.
Autor/in / Beteiligte Person:	Liu, JF ; Chang, TM ; Chen, PH ; Lin, JS ; Tsai, YJ ; Wu, HM ; Lee, CJ
Link:	Full Text Finder (Volltext)
Zeitschrift:	Journal of food biochemistry, Jg. 46 (2022-11-01), Heft 11, S. e14221
Veröffentlichung:	2008- : Hoboken, NJ : Wiley ; <i>Original Publication</i>: Westport, Conn. : Food & Nutrition Press, 2022
Medientyp:	academicJournal
ISSN:	1745-4514 (electronic)
DOI:	10.1111/jfbc.14221
Schlagwort:	Humans Endoplasmic Reticulum Stress Reactive Oxygen Species metabolism Squamous Cell Carcinoma of Head and Neck Apoptosis Autophagy Mouth Neoplasms drug therapy Mouth Neoplasms metabolism Mouth Neoplasms pathology Carcinoma, Squamous Cell drug therapy Carcinoma, Squamous Cell metabolism Carcinoma, Squamous Cell pathology Head and Neck Neoplasms
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: English Publication Type: Journal Article; Research Support, Non-U.S. Gov't Language: English [J Food Biochem] 2022 Nov; Vol. 46 (11), pp. e14221. <i>Date of Electronic Publication: </i>2022 May 21. MeSH Terms: Mouth Neoplasms* / drug therapy ; Mouth Neoplasms* / metabolism ; Mouth Neoplasms* / pathology ; Carcinoma, Squamous Cell* / drug therapy ; Carcinoma, Squamous Cell* / metabolism ; Carcinoma, Squamous Cell* / pathology ; Head and Neck Neoplasms* ; Humans ; Endoplasmic Reticulum Stress ; Reactive Oxygen Species / metabolism ; Squamous Cell Carcinoma of Head and Neck ; Apoptosis ; Autophagy References: Ahamad, M. S., Siddiqui, S., Jafri, A., Ahmad, S., Afzal, M., & Arshad, M. (2014). Induction of apoptosis and antiproliferative activity of naringenin in human epidermoid carcinoma cell through ROS generation and cell cycle arrest. PLoS ONE, 9(10), e110003. https://doi.org/10.1371/journal.pone.0110003. ; Arul, D., & Subramanian, P. 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Naringenin induces endoplasmic reticulum stress-mediated cell apoptosis and autophagy in human oral squamous cell carcinoma cells.