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A key aim in epidemiological neuroscience is identification of markers to assess brain health and monitor therapeutic interventions. Quantitative susceptibility mapping (QSM) is an emerging magnetic resonance imaging technique that measures tissue magnetic susceptibility and has been shown to detect pathological changes in tissue iron, myelin and calcification. We present an open resource of QSM-based imaging measures of multiple brain structures in 35,273 individuals from the UK Biobank prospective epidemiological study. We identify statistically significant associations of 251 phenotypes with magnetic susceptibility that include body iron, disease, diet and alcohol consumption. Genome-wide associations relate magnetic susceptibility to 76 replicating clusters of genetic variants with biological functions involving iron, calcium, myelin and extracellular matrix. These patterns of associations include relationships that are unique to QSM, in particular being complementary to T2* signal decay time measures. These new imaging phenotypes are being integrated into the core UK Biobank measures provided to researchers worldwide, creating the potential to discover new, non-invasive markers of brain health.

Titel:	Phenotypic and genetic associations of quantitative magnetic susceptibility in UK Biobank brain imaging.
Autor/in / Beteiligte Person:	Wang, C ; Martins-Bach, AB ; Alfaro-Almagro, F ; Douaud, G ; Klein, JC ; Llera, A ; Fiscone, C ; Bowtell, R ; Elliott, LT ; Smith, SM ; Tendler, BC ; Miller, KL
Zeitschrift:	Nature neuroscience, Jg. 25 (2022-06-01), Heft 6, S. 818-831
Veröffentlichung:	<2002->: New York, NY : Nature Publishing Group ; <i>Original Publication</i>: New York, NY : Nature America Inc., c1998-, 2022
Medientyp:	academicJournal
ISSN:	1546-1726 (electronic)
DOI:	10.1038/s41593-022-01074-w
Schlagwort:	Brain Mapping methods Iron analysis Magnetic Resonance Imaging methods Phenotype Prospective Studies United Kingdom Biological Specimen Banks Brain diagnostic imaging Brain pathology
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: English Publication Type: Journal Article; Research Support, Non-U.S. Gov't Language: English [Nat Neurosci] 2022 Jun; Vol. 25 (6), pp. 818-831. <i>Date of Electronic Publication: </i>2022 May 23. MeSH Terms: Biological Specimen Banks* ; Brain* / diagnostic imaging ; Brain* / pathology ; Brain Mapping / methods ; Iron / analysis ; Magnetic Resonance Imaging / methods ; Phenotype ; Prospective Studies ; United Kingdom References: Miller, K. L. et al. Multimodal population brain imaging in the UK Biobank prospective epidemiological study. Nat. Neurosci. 19, 1523–1536 (2016). (PMID: 10.1038/nn.4393276434305086094) ; Dekkers, I. A., Jansen, P. R. & Lamb, H. J. Obesity, brain volume, and white matter microstructure at MRI: a cross-sectional UK biobank study. Radiology 291, 763–771 (2019). (PMID: 10.1148/radiol.201918101231012815) ; Cox, S. R. et al. Associations between vascular risk factors and brain MRI indices in UK Biobank. Eur. 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Phenotypic and genetic associations of quantitative magnetic susceptibility in UK Biobank brain imaging.