Einzeltreffer — DigiBib

Platelets, the small, anucleate blood cells that originate from megakaryocytes in the bone marrow, are typically associated with coagulation. However, it is now apparent that platelets are more multifaceted than originally thought, with their function extending beyond their traditional role in hemostasis to acting as important mediators of brain function. In this review, we outline the broad repertoire of platelet function in the central nervous system, focusing on the similarities between platelets and neurons. We also summarize the role that platelets play in the pathophysiology of various neurological diseases, with a particular focus on neuroinflammation and neurodegeneration. Finally, we highlight the exciting prospect of harnessing the unique features of the platelet proteome and extracellular vesicles, which are rich in neurotrophic, antioxidative, and antiinflammatory factors, for the development of novel neuroprotective and neuroregenerative interventions to treat various neurodegenerative and traumatic pathologies.

Titel:	The multifaceted role of platelets in mediating brain function.
Autor/in / Beteiligte Person:	Burnouf, T ; Walker, TL
Link:	Full Text Finder (Volltext)
Zeitschrift:	Blood, Jg. 140 (2022-08-25), Heft 8, S. 815-827
Veröffentlichung:	2021- : [New York] : Elsevier ; <i>Original Publication</i>: New York, Grune & Stratton [etc.], 2022
Medientyp:	academicJournal
ISSN:	1528-0020 (electronic)
DOI:	10.1182/blood.2022015970
Schlagwort:	Hemostasis physiology Blood Platelets physiology Brain physiology
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: English Publication Type: Journal Article; Review Language: English [Blood] 2022 Aug 25; Vol. 140 (8), pp. 815-827. MeSH Terms: Blood Platelets* / physiology ; Brain* / physiology ; Hemostasis / physiology References: PLoS One. 2010 Oct 13;5(10):e13346. (PMID: 20967129) ; Brain. 2021 Nov 29;144(10):3142-3158. (PMID: 34086871) ; Neurochem Int. 2019 Mar;124:41-45. (PMID: 30578840) ; PLoS One. 2013 Sep 19;8(9):e73118. (PMID: 24069173) ; Cell Signal. 2017 Dec;40:210-221. (PMID: 28943410) ; FEBS Lett. 2006 Oct 2;580(22):5313-20. (PMID: 16979629) ; J Gerontol A Biol Sci Med Sci. 2020 Mar 9;75(4):664-670. (PMID: 31336382) ; Prog Neurobiol. 2020 May;188:101783. (PMID: 32142857) ; Nat Rev Immunol. 2019 Dec;19(12):747-760. (PMID: 31409920) ; Curr Neurovasc Res. 2012 Aug;9(3):185-92. (PMID: 22621230) ; J Alzheimers Dis. 2011;25(1):103-9. (PMID: 21368381) ; Front Immunol. 2020 May 05;11:747. (PMID: 32431701) ; World J Psychiatry. 2012 Dec 22;2(6):102-13. (PMID: 24175176) ; Blood Adv. 2020 Jul 14;4(13):3011-3023. (PMID: 32614966) ; Neuroscientist. 2022 Jun;28(3):222-237. (PMID: 33446074) ; Infect Immun. 2006 Jan;74(1):645-53. (PMID: 16369021) ; Exp Neurol. 2009 Sep;219(1):334-40. (PMID: 19523952) ; J Biol Chem. 1990 Sep 15;265(26):15977-83. (PMID: 2118534) ; Immunology. 2018 Jun;154(2):322-328. (PMID: 29325217) ; J Neurosci. 1990 Nov;10(11):3469-78. (PMID: 2230938) ; Sci Rep. 2020 Oct 22;10(1):18061. (PMID: 33093473) ; Am J Med Genet B Neuropsychiatr Genet. 2005 Nov 5;139B(1):101-5. (PMID: 16184606) ; J Neurol Sci. 1994 Dec 20;127(2):207-13. (PMID: 7535841) ; J Biol Chem. 2016 May 6;291(19):9872-81. (PMID: 27006395) ; Neurobiol Aging. 2008 May;29(5):661-8. (PMID: 17174011) ; Blood. 2015 Sep 17;126(12):1483-93. (PMID: 26232171) ; Mol Cell Neurosci. 2003 Jul;23(3):373-82. (PMID: 12837622) ; Curr Gerontol Geriatr Res. 2013;2013:986254. (PMID: 24382959) ; Geriatr Gerontol Int. 2013 Jan;13(1):90-7. (PMID: 22672107) ; Cell Signal. 2016 Dec;28(12):1863-1871. (PMID: 27593518) ; Biomark Med. 2014;8(5):653-61. (PMID: 25123034) ; J Psychiatr Res. 2011 Feb;45(2):220-4. (PMID: 20576277) ; Sci Transl Med. 2016 May 25;8(340):340ra72. (PMID: 27225182) ; JAMA Neurol. 2019 Jan 1;76(1):35-40. (PMID: 30383097) ; Platelets. 2021 Apr 3;32(3):340-351. (PMID: 32597341) ; Clin Exp Pharmacol Physiol. 1987 Jun;14(6):547-50. (PMID: 2960476) ; Br J Haematol. 1967 May;13(3):269-88. (PMID: 6025241) ; J Neurol. 2015 Jun;262(6):1493-503. (PMID: 25893255) ; Res Pract Thromb Haemost. 2019 Sep 16;3(4):564-565. (PMID: 31624775) ; Neurobiol Aging. 2014 Jul;35(7):1582-95. (PMID: 24524966) ; Nat Immunol. 2011 Oct 30;12(12):1194-201. (PMID: 22037602) ; Transfus Med Rev. 2007 Apr;21(2):101-17. (PMID: 17397761) ; Mol Psychiatry. 2018 Sep;23(9):1948-1956. (PMID: 29086767) ; J Immunol. 2012 Jul 15;189(2):916-23. (PMID: 22706078) ; Curr Angiogenes. 2013;2(1):54-59. (PMID: 25374792) ; J Proteomics. 2014 Apr 14;101:130-40. (PMID: 24549006) ; Brain. 1993 Dec;116 ( Pt 6):1451-63. (PMID: 8293280) ; J Biomed Sci. 2019 Oct 31;26(1):89. (PMID: 31666073) ; Blood. 2008 Feb 1;111(3):1227-33. (PMID: 17962514) ; Lancet Neurol. 2008 Jan;7(1):41-9. (PMID: 18068522) ; J Biol Chem. 2001 May 18;276(20):17036-43. (PMID: 11278299) ; J Thromb Haemost. 2014 Dec;12(12):2054-64. (PMID: 25255925) ; J Thromb Haemost. 2016 May;14(5):991-4. (PMID: 26817920) ; Blood. 2014 Oct 2;124(14):2173-83. (PMID: 25082876) ; Neurology. 1990 Aug;40(8):1302-3. (PMID: 2166249) ; J Tissue Eng Regen Med. 2017 Nov;11(11):3236-3240. (PMID: 27943621) ; Neurobiol Aging. 2007 Mar;28(3):336-42. (PMID: 16442186) ; Front Pharmacol. 2019 Sep 12;10:1008. (PMID: 31572186) ; Alzheimers Dement (N Y). 2016 Oct 27;2(4):250-257. (PMID: 29067312) ; Ultrastruct Pathol. 2011 Apr;35(2):52-9. (PMID: 21299344) ; Stem Cell Reports. 2019 Apr 9;12(4):667-679. (PMID: 30905740) ; Acta Neuropathol Commun. 2014 Jun 16;2:65. (PMID: 24934666) ; Brain Behav Immun. 2017 Jan;59:173-189. (PMID: 27658543) ; Int J Neurosci. 2011 Mar;121(3):149-58. (PMID: 21138397) ; Front Cell Neurosci. 2021 Jul 14;15:680126. (PMID: 34335186) ; J Immunol. 2019 Nov 1;203(9):2357-2367. (PMID: 31636134) ; Blood. 2000 Nov 15;96(10):3334-42. (PMID: 11071625) ; J Alzheimers Dis. 2012;31(1):65-9. (PMID: 22495344) ; Int J Neurosci. 2013 May;123(5):287-99. (PMID: 23301959) ; J Neurol Neurosurg Psychiatry. 2019 Mar;90(3):272-283. (PMID: 30567722) ; Biomaterials. 2017 Oct;142:77-89. (PMID: 28728000) ; Sci Rep. 2016 Jun 27;6:28447. (PMID: 27345467) ; Front Biosci (Landmark Ed). 2018 Jan 1;23(4):726-751. (PMID: 28930569) ; J Clin Med. 2019 Feb 01;8(2):. (PMID: 30717130) ; Front Immunol. 2018 Mar 02;9:406. (PMID: 29599771) ; J Neural Transm (Vienna). 1999;106(7-8):685-92. (PMID: 10907727) ; Blood Rev. 2009 Jul;23(4):177-89. (PMID: 19450911) ; Inflammation. 2019 Feb;42(1):290-305. (PMID: 30218321) ; Int J Mol Sci. 2021 Sep 14;22(18):. (PMID: 34576080) ; Neurobiol Dis. 2021 Nov;159:105512. (PMID: 34537329) ; J Alzheimers Dis. 2019;71(3):993-1004. (PMID: 31450503) ; Neurobiol Aging. 2009 Oct;30(10):1552-62. (PMID: 18255193) ; Ann Neurol. 1995 Jun;37(6):714-22. (PMID: 7778844) ; Biochem Biophys Res Commun. 1994 Dec 15;205(2):1431-7. (PMID: 7802679) ; Brain Behav Immun. 2018 Nov;74:7-27. (PMID: 30217533) ; Nature. 1998 Feb 5;391(6667):591-4. (PMID: 9468137) ; Front Immunol. 2020 Oct 02;11:571083. (PMID: 33123145) ; Eur J Paediatr Neurol. 2013 Mar;17(2):117-25. (PMID: 22951324) ; Adv Drug Deliv Rev. 2019 Aug;148:146-180. (PMID: 30797956) ; BMC Neurol. 2017 Feb 23;17(1):40. (PMID: 28231822) ; Ann Neurol. 2000 May;47(5):641-3. (PMID: 10805335) ; Blood. 1987 Aug;70(2):475-83. (PMID: 3607284) ; Platelets. 2017 May;28(3):263-271. (PMID: 28102751) ; J Neurol Neurosurg Psychiatry. 1970 Aug;33(4):506-10. (PMID: 5505678) ; Front Immunol. 2020 Oct 06;11:548631. (PMID: 33123127) ; Exp Neurol. 2015 Jul;269:75-89. (PMID: 25819103) ; J Proteomics. 2012 Dec 5;76 Spec No.:287-96. (PMID: 22415276) ; Eur J Pharmacol. 2008 Jul 7;588(2-3):259-66. (PMID: 18511035) ; J Neural Transm (Vienna). 2010 Sep;117(9):1093-8. (PMID: 20665056) ; JAMA Neurol. 2016 Nov 01;73(11):1325-1333. (PMID: 27598869) ; Blood. 1999 Dec 1;94(11):3791-9. (PMID: 10572093) ; Platelets. 2017 May;28(3):214-221. (PMID: 28102737) ; Front Neurol. 2019 Aug 02;10:835. (PMID: 31428042) ; Arterioscler Thromb Vasc Biol. 2021 Jan;41(1):87-96. (PMID: 33028092) ; J Proteomics. 2015 May 21;121:56-66. (PMID: 25835965) ; Front Immunol. 2021 Feb 19;12:620963. (PMID: 33679764) ; Neuron. 1993 Mar;10(3):553-7. (PMID: 8461142) ; Sci Rep. 2019 Jan 23;9(1):389. (PMID: 30674980) ; Sci Signal. 2016 May 24;9(429):ra52. (PMID: 27221710) ; Biochemistry. 1984 Mar 13;23(6):1224-9. (PMID: 6424707) ; Stem Cells Transl Med. 2019 May;8(5):490-499. (PMID: 30706999) ; Clin Biochem. 2019 Oct;72:71-80. (PMID: 30954436) ; Blood Rev. 2021 Mar;46:100733. (PMID: 32682574) ; Neurology. 2020 Jul 21;95(3):e320-e331. (PMID: 32213642) ; J Mol Neurosci. 2012 Jul;47(3):659-65. (PMID: 22290563) ; Transfus Med Rev. 2020 Oct;34(4):209-220. (PMID: 33051111) ; Science. 2016 Aug 19;353(6301):777-83. (PMID: 27540165) ; J Control Release. 2015 Apr 10;203:170-80. (PMID: 25702964) ; Sci Rep. 2021 Jun 11;11(1):12358. (PMID: 34117303) ; Semin Thromb Hemost. 2022 Apr;48(3):382-404. (PMID: 34624913) ; Platelets. 2021 Feb 17;32(2):226-237. (PMID: 32106742) ; Curr Alzheimer Res. 2014;11(9):862-8. (PMID: 25430938) ; Cell Stem Cell. 2008 Sep 11;3(3):265-78. (PMID: 18786414) ; Prog Mol Biol Transl Sci. 2017;146:259-302. (PMID: 28253988) ; J Neuroinflammation. 2008 Jun 27;5:27. (PMID: 18588683) ; J Extracell Vesicles. 2014 Aug 06;3:. (PMID: 25147646) ; Exp Neurol. 1997 Apr;144(2):416-9. (PMID: 9168841) ; Trends Biotechnol. 2020 Jan;38(1):13-23. (PMID: 31326128) ; Neurology. 2001 Jan 23;56(2):270-2. (PMID: 11160972) ; PLoS One. 2016 Mar 17;11(3):e0151702. (PMID: 26986758) ; Theranostics. 2021 Jul 13;11(17):8129-8142. (PMID: 34373732) ; J Neural Transm (Vienna). 2012 Jul;119(7):815-9. (PMID: 22573143) ; Curr Pharm Des. 2007;13(26):2640-6. (PMID: 17897006) ; J Immunol. 2015 Jun 15;194(12):5579-87. (PMID: 26048965) ; Front Neurosci. 2020 Mar 03;14:129. (PMID: 32194368) ; J Biol Chem. 1995 Jun 9;270(23):14140-7. (PMID: 7775475) ; Lancet. 1965 Nov 27;2(7422):1109-10. (PMID: 4158810) ; Blood. 2006 Jan 15;107(2):637-41. (PMID: 16179373) ; Biomaterials. 2022 Jan;280:121311. (PMID: 34952382) ; Brain Res. 1996 Feb 12;709(1):122-301. (PMID: 8869564) ; Circ Res. 2015 Oct 9;117(9):779-92. (PMID: 26294656) ; J Clin Med. 2021 Feb 20;10(4):. (PMID: 33672766) ; PLoS One. 2014 Feb 25;9(2):e89745. (PMID: 24587005) ; Neurobiol Aging. 1997 Mar-Apr;18(2):147-53. (PMID: 9258891) ; Aging (Albany NY). 2021 Mar 5;13(5):7644-7659. (PMID: 33668038) ; Nat Med. 2005 Nov;11(11):1167-9. (PMID: 16258538) ; Cell Signal. 2014 Sep;26(9):2040-50. (PMID: 24928203) ; Br J Pharmacol. 2005 Jul;145(6):792-9. (PMID: 15880141) ; Thromb Res. 1985 Jul 1;39(1):63-79. (PMID: 3839944) ; ACS Biomater Sci Eng. 2021 Dec 13;7(12):5823-5835. (PMID: 34846835) ; Proc Natl Acad Sci U S A. 2016 May 3;113(18):E2536-45. (PMID: 27091993) ; Alzheimers Res Ther. 2020 Jun 8;12(1):70. (PMID: 32513253) ; Prog Neurobiol. 2019 Dec;183:101695. (PMID: 31550515) ; PLoS One. 2013;8(3):e58979. (PMID: 23555611) ; Thromb Haemost. 2015 Aug 31;114(3):449-58. (PMID: 26293514) ; J Neuroinflammation. 2010 Feb 03;7:10. (PMID: 20128908) ; Alzheimers Dement. 2020 Oct;16(10):1412-1425. (PMID: 32715623) ; PLoS One. 2010 Mar 03;5(3):e9505. (PMID: 20209079) ; J Leukoc Biol. 1999 Oct;66(4):567-74. (PMID: 10534110) ; Proc Natl Acad Sci U S A. 2018 Feb 13;115(7):E1550-E1559. (PMID: 29386381) ; Thromb Haemost. 2013 Aug;110(2):323-30. (PMID: 23765126) ; Platelets. 2009 Aug;20(5):328-33. (PMID: 19637096) ; Trends Biotechnol. 2021 Jun;39(6):598-612. (PMID: 33160678) ; Front Aging Neurosci. 2019 Jul 02;11:151. (PMID: 31312134) Entry Date(s): Date Created: 20220524 Date Completed: 20220829 Latest Revision: 20230209 Update Code: 20240513 PubMed Central ID: PMC9412009

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The multifaceted role of platelets in mediating brain function.