Einzeltreffer — DigiBib

Objective: C-reactive protein (CRP) is an important index for evaluating the disease activity of rheumatoid arthritis (RA). CRP may play a direct role in bone destruction in RA. Studies have demonstrated that serum CRP levels had a close correlation with tissue inflammation scores in patients with RA. In addition, genetic factors play a crucial role in the development of RA. In this study, we aimed to investigate the relationship between the CRP gene variants (rs1205 polymorphism) and the risk of RA in Chinese Han population.

Methods: 502 RA patients and 581 controls were included in this study. The associations between CRP gene variants and CRP levels and RA risk were investigated.

Results: We found that TT/ TT + CT genotype was significantly related with an increased risk of RA (TT vs CC: OR, 1.56, 95%CI, 1.01-2.40, P = 0.045; TT + CT vs CC: OR, 1.30, 95%CI, 1.02-1.65, P = 0.032). In addition, T allele was shown to associate with an elevated risk of RA. After subgroup analysis, we found that rs1205 polymorphism was significantly related with an enhanced risk of RA among females, individuals lower than 60 years, and subjects with a BMI > 25 kg/m 2 . Furthermore, data showed that the CRP gene rs1205 polymorphism correlated with CRP and ESR levels. Furthermore, the TT genotype was significantly associated with a reduction of CRP levels compared with CT or CC genotype.

Conclusions: To sum up, this study reveals that rs1205 polymorphism of the CRP gene is related with an increased risk of RA and CRP levels in Chinese Han population. Key Points • The CRP gene rs1205 polymorphism is related with a higher risk of RA. • The CRP gene rs1205 polymorphism correlates with CRP and ESR levels. • The TT genotype of rs1205 polymorphism is linked with a reduction of CRP levels.

Titel:	Correlation of CRP genotypes with serum CRP levels and the risk of rheumatoid arthritis in Chinese Han population.
Autor/in / Beteiligte Person:	Liu, S ; Li, J ; Li, Y ; Liu, Y ; Wang, K ; Pan, W
Link:	Full Text Finder (Volltext)
Zeitschrift:	Clinical rheumatology, Jg. 41 (2022-11-01), Heft 11, S. 3325-3330
Veröffentlichung:	<2008->: Heidelberg : Springer ; <i>Original Publication</i>: Brussels : Acta Medica Belgica, [1982-, 2022
Medientyp:	academicJournal
ISSN:	1434-9949 (electronic)
DOI:	10.1007/s10067-022-06306-9
Schlagwort:	Case-Control Studies China Female Gene Frequency Genetic Predisposition to Disease Genotype Humans Polymorphism, Single Nucleotide Arthritis, Rheumatoid genetics C-Reactive Protein analysis C-Reactive Protein genetics
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: English Publication Type: Journal Article Language: English [Clin Rheumatol] 2022 Nov; Vol. 41 (11), pp. 3325-3330. <i>Date of Electronic Publication: </i>2022 Jul 28. MeSH Terms: Arthritis, Rheumatoid* / genetics ; C-Reactive Protein* / analysis ; C-Reactive Protein* / genetics ; Case-Control Studies ; China ; Female ; Gene Frequency ; Genetic Predisposition to Disease ; Genotype ; Humans ; Polymorphism, Single Nucleotide References: Kaur I, Behl T, Bungau S, Kumar A, Mehta V, Setia D, Uddin MS, Zengin G, Aleya L, Arora S (2020) Exploring the therapeutic promise of targeting HMGB1 in rheumatoid arthritis. Life Sci 258:118164. https://doi.org/10.1016/j.lfs.2020.118164. (PMID: 10.1016/j.lfs.2020.11816432739467) ; Sparks JA (2019) Rheumatoid arthritis. Ann Intern Med 170(1):ITC1–ITC16. https://doi.org/10.7326/AITC201901010. (PMID: 10.7326/AITC20190101030596879) ; Jin S, Li M, Fang Y, Li Q, Liu J, Duan X, Liu Y, Wu R, Shi X, Wang Y, Jiang Z, Wang Y, Yu C, Wang Q, Tian X, Zhao Y, Zeng X, Co-authors C (2017) Chinese Registry of rheumatoid arthritis (CREDIT): II Prevalence and risk factors of major comorbidities in Chinese patients with rheumatoid arthritis. Arthritis Res Ther 19(1):251. https://doi.org/10.1186/s13075-017-1457-z. (PMID: 10.1186/s13075-017-1457-z291416885688621) ; Smolen JS, Aletaha D, McInnes IB (2016) Rheumatoid arthritis. Lancet 388(10055):2023–2038. https://doi.org/10.1016/S0140-6736(16)30173-8. (PMID: 10.1016/S0140-6736(16)30173-827156434) ; Smolen JS, Aletaha D, Barton A, Burmester GR, Emery P, Firestein GS, Kavanaugh A, McInnes IB, Solomon DH, Strand V, Yamamoto K (2018) Rheumatoid arthritis. Nat Rev Dis Primers 4:18001. https://doi.org/10.1038/nrdp.2018.1. (PMID: 10.1038/nrdp.2018.129417936) ; McInnes IB, Schett G (2017) Pathogenetic insights from the treatment of rheumatoid arthritis. Lancet 389(10086):2328–2337. https://doi.org/10.1016/S0140-6736(17)31472-1. (PMID: 10.1016/S0140-6736(17)31472-128612747) ; Okada Y, Eyre S, Suzuki A, Kochi Y, Yamamoto K (2019) Genetics of rheumatoid arthritis: 2018 status. Ann Rheum Dis 78(4):446–453. https://doi.org/10.1136/annrheumdis-2018-213678. (PMID: 10.1136/annrheumdis-2018-21367830530827) ; Traylor M, Curtis C, Patel H, Breen G, Hyuck Lee S, Xu X, Newhouse S, Dobson R, Steer S, Cope AP, Markus HS, Lewis CM, Scott IC (2017) Genetic and environmental risk factors for rheumatoid arthritis in a UK African ancestry population: the GENRA case-control study. Rheumatology (Oxford) 56(8):1282–1292. https://doi.org/10.1093/rheumatology/kex048. (PMID: 10.1093/rheumatology/kex048) ; Leng RX, Di DS, Ni J, Wu XX, Zhang LL, Wang XF, Liu RS, Huang Q, Fan YG, Pan HF, Wang B, Ye DQ (2020) Identification of new susceptibility loci associated with rheumatoid arthritis. Ann Rheum Dis 79(12):1565–1571. https://doi.org/10.1136/annrheumdis-2020-217351. (PMID: 10.1136/annrheumdis-2020-21735132868391) ; Kwon YC, Lim J, Bang SY, Ha E, Hwang MY, Yoon K, Choe JY, Yoo DH, Lee SS, Lee J, Chung WT, Kim TH, Sung YK, Shim SC, Choi CB, Jun JB, Kang YM, Shin JM, Lee YK, Cho SK, Kim BJ, Lee HS, Kim K, Bae SC (2020) Genome-wide association study in a Korean population identifies six novel susceptibility loci for rheumatoid arthritis. Ann Rheum Dis 79(11):1438–1445. https://doi.org/10.1136/annrheumdis-2020-217663. (PMID: 10.1136/annrheumdis-2020-21766332723749) ; Saxena R, Plenge RM, Bjonnes AC, Dashti HS, Okada Y, Gad El Haq W, Hammoudeh M, Al Emadi S, Masri BK, Halabi H, Badsha H, Uthman IW, Margolin L, Gupta N, Mahfoud ZR, Kapiri M, Dargham SR, Aranki G, Kazkaz LA, Arayssi T (2017) A multinational Arab genome-wide association study identifies new genetic associations for rheumatoid arthritis. Arthritis Rheumatol 69(5):976–985. https://doi.org/10.1002/art.40051. (PMID: 10.1002/art.4005128118524) ; Rhodes B, Furnrohr BG, Vyse TJ (2011) C-reactive protein in rheumatology: biology and genetics. Nat Rev Rheumatol 7(5):282–289. https://doi.org/10.1038/nrrheum.2011.37. (PMID: 10.1038/nrrheum.2011.3721468143) ; Pepys MB, Hirschfield GM (2003) C-reactive protein: a critical update. J Clin Invest 111(12):1805–1812. https://doi.org/10.1172/JCI18921. (PMID: 10.1172/JCI1892112813013161431) ; Yao Z, Zhang Y, Wu H (2019) Regulation of C-reactive protein conformation in inflammation. Inflamm Res 68(10):815–823. https://doi.org/10.1007/s00011-019-01269-1. (PMID: 10.1007/s00011-019-01269-131312858) ; Shimada K, Komiya A, Yokogawa N, Nishino J, Sugii S, Tohma S (2017) Impact of the size and number of swollen joints on serum C-reactive protein level and erythrocyte sedimentation rate in rheumatoid arthritis: a cross-sectional study in Japan. Clin Rheumatol 36(2):427–431. https://doi.org/10.1007/s10067-016-3482-8. (PMID: 10.1007/s10067-016-3482-827882446) ; Pope JE, Choy EH (2021) C-reactive protein and implications in rheumatoid arthritis and associated comorbidities. Semin Arthritis Rheum 51(1):219–229. https://doi.org/10.1016/j.semarthrit.2020.11.005. (PMID: 10.1016/j.semarthrit.2020.11.00533385862) ; Shafran IH, Alasti F, Smolen JS, Aletaha D (2020) Implication of baseline levels and early changes of C-reactive protein for subsequent clinical outcomes of patients with rheumatoid arthritis treated with tocilizumab. Ann Rheum Dis 79(7):874–882. https://doi.org/10.1136/annrheumdis-2019-215987. (PMID: 10.1136/annrheumdis-2019-21598732371387) ; Delongui F, Lozovoy MAB, Iriyoda TMV, Costa NT, Stadtlober NP, Alfieri DF, Flauzino T, Dichi I, Simao ANC, Reiche EMV (2017) C-reactive protein +1444CT (rs1130864) genetic polymorphism is associated with the susceptibility to systemic lupus erythematosus and C-reactive protein levels. Clin Rheumatol 36(8):1779–1788. https://doi.org/10.1007/s10067-017-3695-5. (PMID: 10.1007/s10067-017-3695-528567557) ; Ammitzboll CG, Steffensen R, Bogsted M, Horslev-Petersen K, Hetland ML, Junker P, Johansen JS, Podenphant J, Ostergaard M, Ellingsen T, Stengaard-Pedersen K (2014) CRP genotype and haplotype associations with serum C-reactive protein level and DAS28 in untreated early rheumatoid arthritis patients. Arthritis Res Ther 16(5):475. https://doi.org/10.1186/s13075-014-0475-3. (PMID: 10.1186/s13075-014-0475-3253594324247621) ; Rhodes B, Merriman ME, Harrison A, Nissen MJ, Smith M, Stamp L, Steer S, Merriman TR, Vyse TJ (2010) A genetic association study of serum acute-phase C-reactive protein levels in rheumatoid arthritis: implications for clinical interpretation. PLoS Med 7(9):e1000341. https://doi.org/10.1371/journal.pmed.1000341. (PMID: 10.1371/journal.pmed.1000341208777162943443) ; Plant D, Ibrahim I, Lunt M, Eyre S, Flynn E, Hyrich KL, Morgan AW, Wilson AG, Isaacs JD, Bragggss BA (2012) Correlation of C-reactive protein haplotypes with serum C-reactive protein level and response to anti-tumor necrosis factor therapy in UK rheumatoid arthritis patients: results from the Biologics in Rheumatoid Arthritis Genetics and Genomics Study Syndicate cohort. Arthritis Res Ther 14(5):R214. https://doi.org/10.1186/ar4052. (PMID: 10.1186/ar4052230394023580526) ; Aletaha D, Neogi T, Silman AJ, Funovits J, Felson DT, Bingham CO 3rd, Birnbaum NS, Burmester GR, Bykerk VP, Cohen MD, Combe B, Costenbader KH, Dougados M, Emery P, Ferraccioli G, Hazes JM, Hobbs K, Huizinga TW, Kavanaugh A, Kay J, Kvien TK, Laing T, Mease P, Menard HA, Moreland LW, Naden RL, Pincus T, Smolen JS, Stanislawska-Biernat E, Symmons D, Tak PP, Upchurch KS, Vencovsky J, Wolfe F, Hawker G (2010) 2010 rheumatoid arthritis classification criteria: an American College of Rheumatology/European League Against Rheumatism collaborative initiative. Ann Rheum Dis 69(9):1580–1588. https://doi.org/10.1136/ard.2010.138461. (PMID: 10.1136/ard.2010.13846120699241) ; Wipff J, Dieude P, Avouac J, Hachulla E, Cracowski JL, Diot E, Mouthon L, Sibilia J, Tiev K, Meyer O, Kahan A, Boileau C, Allanore Y (2014) Association study of CRP gene in systemic sclerosis in European Caucasian population. Rheumatol Int 34(3):389–392. https://doi.org/10.1007/s00296-013-2673-8. (PMID: 10.1007/s00296-013-2673-823397258) ; Cheng Y, Dang A, Lv N, Gao Q, Chen B, Liu G (2016) Serum C-reactive protein level but not its gene polymorphism is associated with Takayasu arteritis. Clin Rheumatol 35(3):673–678. https://doi.org/10.1007/s10067-014-2674-3. (PMID: 10.1007/s10067-014-2674-324894103) ; Nair AM, Goel R, Hindhumati M, Shah K, Chandana P, Jayaseelan V, Jayakanthan K, Joseph G, Danda S, Danda D (2018) C-reactive protein gene polymorphisms (rs1205) in Asian Indian patients with Takayasu arteritis: associations and phenotype correlations. Int J Rheum Dis 21(3):732–739. https://doi.org/10.1111/1756-185X.13180. (PMID: 10.1111/1756-185X.1318029024426) ; Atisha-Fregoso Y, Lima G, Carrillo-Maravilla E, Posadas-Sanchez R, Perez-Hernandez N, Banos-Pelaez M, Iturralde-Chavez A, Hernandez-Diaz N, Jakez-Ocampo J, Rodriguez-Perez JM, Vargas-Alarcon G, Llorente L, Romero-Diaz J (2018) C-reactive protein (CRP) polymorphisms and haplotypes are associated with SLE susceptibility and activity but not with serum CRP levels in Mexican population. Clin Rheumatol 37(7):1817–1824. https://doi.org/10.1007/s10067-018-4059-5. (PMID: 10.1007/s10067-018-4059-529556849) ; Enocsson H, Sjowall C, Kastbom A, Skogh T, Eloranta ML, Ronnblom L, Wettero J (2014) Association of serum C-reactive protein levels with lupus disease activity in the absence of measurable interferon-alpha and a C-reactive protein gene variant. Arthritis Rheumatol 66(6):1568–1573. https://doi.org/10.1002/art.38408. (PMID: 10.1002/art.3840824574329) ; Danila MI, Westfall AO, Raman K, Chen L, Reynolds RJ, Hughes LB, Arnett DK, McGwin G, Szalai AJ, van der Heijde DM, Conn D, Callahan LF, Moreland LW, Bridges SL Jr (2015) The role of genetic variants in CRP in radiographic severity in African Americans with early and established rheumatoid arthritis. Genes Immun 16(7):446–451. https://doi.org/10.1038/gene.2015.24. (PMID: 10.1038/gene.2015.24262260104707038) Contributed Indexing: Keywords: C reactive protein; Case–control study; Rheumatoid arthritis; Single nucleotide polymorphism Substance Nomenclature: 9007-41-4 (C-Reactive Protein) Entry Date(s): Date Created: 20220727 Date Completed: 20221018 Latest Revision: 20221019 Update Code: 20231215

Klicken Sie ein Format an und speichern Sie dann die Daten oder geben Sie eine Empfänger-Adresse ein und lassen Sie sich per Email zusenden.

BibTeX Citavi, JabRef, u.a.
(Literaturverwaltung)

PDF kein Volltext!
(Merkzettel, Notizen)

RIS Endnote, Citavi u.a.
(Literaturverwaltung)

MODS
(XML zur Weiterverarbeitung)

oder

Wählen Sie das für Sie passende Zitationsformat und kopieren Sie es dann in die Zwischenablage, lassen es sich per Mail zusenden oder speichern es als PDF-Datei.

Gewünschter Zitations-Stil:

oder

Bitte prüfen Sie, ob die Zitation formal korrekt ist, bevor Sie sie in einer Arbeit verwenden. Benutzen Sie gegebenenfalls den "Exportieren"-Dialog, wenn Sie ein Literaturverwaltungsprogramm verwenden und die Zitat-Angaben selbst formatieren wollen.

Correlation of CRP genotypes with serum CRP levels and the risk of rheumatoid arthritis in Chinese Han population.