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Objectives: To investigate the level of neuropsychological development in human immunodeficiency virus (HIV)-exposed uninfected (HEU) infants/young children and the influence of maternal HIV infection on the neuropsychological development of HEU infants/young children.

Methods: A total of 141 HEU infants/young children, aged 0-18 months and born to HIV-infected mothers, who were managed in four maternal and child health care hospitals in Yunnan Province of China from June 2019 to December 2020 and met the inclusion criteria were enrolled as the HEU group. A total of 141 HIV-unexposed uninfected (HUU) infants/young children who were born to healthy mothers and managed in the same hospitals, matched at a ratio of 1:1 based on sex, age, method of birth, birth weight, and gestational age, were enrolled as controls. Griffiths Development Scales-Chinese Edition was used to assess the development in the five domains of locomotion, personal-social, hearing and language, eye-hand co-ordination, and performance (visual perception and space integration ability). A questionnaire survey was performed to collect relevant information. The multivariate logistic regression analysis was used to assess the influence of maternal HIV infection on the neuropsychological development of HEU infants/young children.

Results: Compared with the HUU group, the HEU group had significantly higher detection rates of retardation in the domains of hearing and language and performance ( P <0.05). The multivariate logistic regression analysis showed that maternal HIV infection increased the risk of retardation in the domains of hearing and language ( OR =2.661, 95% CI : 1.171-6.047, P <0.05) and performance ( OR =2.321, 95% CI : 1.156-4.658, P <0.05).

Conclusions: Maternal HIV infection can negatively affect the development of hearing and language and performance in HEU infants/young children, and further studies are needed to clarify related mechanisms.

Titel:	[Neuropsychological development of human immunodeficiency virus-exposed uninfected infants/young children].
Autor/in / Beteiligte Person:	Xia, W ; Zheng, JR ; Zheng, M ; Li, WJ ; Jiang, CQ ; Wu, YT ; Huang, ZR ; Guo, GP
Zeitschrift:	Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics, Jg. 24 (2022-09-15), Heft 9, S. 967-972
Veröffentlichung:	Changsha : Zhongguo dang dai er ke za zhi she, 1999-, 2022
Medientyp:	academicJournal
ISSN:	1008-8830 (print)
DOI:	10.7499/j.issn.1008-8830.2203037
Schlagwort:	Child Child, Preschool China Female HIV Humans Infant Mothers HIV Infections
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: Chinese Transliterated Title: 人类免疫缺陷病毒暴露未感染婴幼儿的神经心理发育状况. Publication Type: Journal Article Language: Chinese [Zhongguo Dang Dai Er Ke Za Zhi] 2022 Sept 15; Vol. 24 (9), pp. 967-972. MeSH Terms: HIV Infections* ; Child ; Child, Preschool ; China ; Female ; HIV ; Humans ; Infant ; Mothers References: AIDS. 2016 Sep 24;30(15):2351-60. (PMID: 27456985) ; Childs Nerv Syst. 2021 Apr;37(4):1185-1190. (PMID: 33009607) ; Curr HIV Res. 2014;12(6):406-14. (PMID: 25613136) ; BMC Res Notes. 2016 Oct 12;9(1):463. (PMID: 27733206) ; Clin Exp Immunol. 2014 Apr;176(1):11-22. (PMID: 24325737) ; J Acquir Immune Defic Syndr. 2014 Nov 1;67(3):316-22. (PMID: 25314252) ; J Med Assoc Thai. 2005 Dec;88(12):1873-9. (PMID: 16518988) ; Curr HIV/AIDS Rep. 2019 Dec;16(6):501-513. (PMID: 31732866) ; AIDS Patient Care STDS. 2009 Jun;23(6):415-21. (PMID: 19415986) ; Nat Med. 2006 Dec;12(12):1365-71. (PMID: 17115046) ; Pediatrics. 2012 Nov;130(5):e1326-44. (PMID: 23118140) ; Lancet Infect Dis. 2016 Jun;16(6):e92-e107. (PMID: 27049574) ; Br Med Bull. 2018 Sep 1;127(1):55-68. (PMID: 29868901) ; Lancet Child Adolesc Health. 2019 Nov;3(11):803-813. (PMID: 31515160) ; Nat Rev Neurol. 2014 Nov;10(11):643-60. (PMID: 25311587) ; Pediatr Infect Dis J. 2018 Jul;37(7):678-685. (PMID: 29278615) ; AIDS. 1997 Jul 15;11(9):1135-44. (PMID: 9233461) ; Pediatr Int. 2018 Jul;60(7):618-625. (PMID: 29663621) ; Medicine (Baltimore). 2016 Jan;95(4):e2577. (PMID: 26825902) ; Science. 2016 Aug 19;353(6301):772-7. (PMID: 27540164) ; J Int AIDS Soc. 2018 May;21(5):e25106. (PMID: 29722482) ; Front Pediatr. 2018 May 30;6:157. (PMID: 29900165) ; Pediatrics. 2017 Oct;140(4):. (PMID: 28912368) ; Semin Immunopathol. 2016 Nov;38(6):727-738. (PMID: 27392971) ; AIDS. 2018 Aug 24;32(13):1781-1791. (PMID: 29794831) ; Front Immunol. 2016 Sep 28;7:383. (PMID: 27733852) Contributed Indexing: Keywords: Child; Human immunodeficiency virus-exposure; Neuropsychological development ; Local Abstract: [Publisher, Chinese] 目的 : 研究人类免疫缺陷病毒（human immunodeficiency virus，HIV）暴露未感染（HIV-exposed uninfected，HEU）婴幼儿神经心理发育水平，探讨母亲HIV感染对HEU婴幼儿神经心理发育的影响。方法 : 选取2019年6月至2020年12月在云南省4家妇幼保健院专案管理且符合纳入标准的141名0~18月龄HIV感染母亲所生未感染HIV，即HEU婴幼儿作为HEU组，以性别、年龄、出生方式、出生体重、胎龄为配对条件，按1∶1配对141名健康母亲所生婴幼儿，即无HIV暴露、无HIV感染（HIV-unexposed uninfected，HUU）婴幼儿为对照，应用Griffiths发育评估量表中文版（Griffiths Development Scales-Chinese Edition，GDS-C）评估运动、个人-社会、听力语言、手眼协调、表现（视感知空间整合能力）5个领域发育情况，同时采用问卷调查方式收集有关信息。采用多因素logistic回归分析探讨母亲HIV感染对HEU婴幼儿神经心理发育的影响。结果 : HEU组听力语言和表现2个领域迟缓检出率显著高于HUU组（ P <0.05）。多因素logistic回归分析显示，HIV暴露增加了婴幼儿听力语言（ OR =2.661，95% CI ：1.171~6.047）和表现（ OR =2.321，95% CI ：1.156~4.658）2个领域迟缓发生的风险（ P <0.05）。结论 : 母亲感染HIV可对其分娩的未感染HIV婴幼儿听力语言和表现领域的发育产生负面影响，其机制有待进一步研究。. Entry Date(s): Date Created: 20220916 Date Completed: 20220919 Latest Revision: 20220928 Update Code: 20240513 PubMed Central ID: PMC9495237

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[Neuropsychological development of human immunodeficiency virus-exposed uninfected infants/young children].