Maternal opioid addiction: A potential cause of elevated 17-OH progesterone in neonatal screening.

Francois-Bic, S ; Legagneur, C ; et al.

In: Archives de pediatrie : organe officiel de la Societe francaise de pediatrie, Jg. 30 (2023-02-01), Heft 2, S. 77-82

academicJournal

Background: Congenital adrenal hyperplasia (CAH) is a disease that is part of neonatal screening. There are many causes of false-positive results on neonatal screening, and maternal opioid consumption during pregnancy is suspected to increase 17-hydroxyprogesterone (17-OHP) levels at birth. The aim of this study was to determine the effect of maternal drug consumption on 17-OHP values on neonatal screening.

Material and Methods: We studied 17-OHP levels of term newborns with reported maternal drug consumption born at the Maternity Hospital of Nancy between 2002 and 2018. These infants were matched with newborns of mothers without drug addiction. The 17-OHP levels, withdrawal syndromes, birth parameters, and maternal characteristics were compared between the two groups.

Results: The study included 241 patients (121 in the drug-exposed group, 120 in the control group). The mean 17-OHP levels in newborns of mothers with substance addiction were 9.83 nmol/L compared to 4.90 nmol/L (p=0.0001) in the control group. Newborns exposed to drugs were smaller (p=0.0001), lighter (p=0.0001), had smaller head circumference (p=0.0001), and had lower Apgar scores (p=0.004 at 1 min and p=0.0001 at 5 min). The 17-OHP level did not differ in cases of withdrawal syndrome in drug-exposed newborn (p=0.911).

Conclusion: A significant increase in 17-OHP levels was observed in newborns exposed to drugs, with no influence of withdrawal syndrome on 17-OHP levels. Maternal substance addiction may be associated with moderately increased 17-OHP levels during neonatal screening.

Competing Interests: Declaration of Interest The authors have indicated they have no potential conflicts of interest to disclose.

Titel:	Maternal opioid addiction: A potential cause of elevated 17-OH progesterone in neonatal screening.
Autor/in / Beteiligte Person:	Francois-Bic, S ; Legagneur, C ; Hubert, C ; Guéant-Rodriguez, RM ; Leheup, B ; Albuisson, E ; Renard, E
Zeitschrift:	Archives de pediatrie : organe officiel de la Societe francaise de pediatrie, Jg. 30 (2023-02-01), Heft 2, S. 77-82
Veröffentlichung:	Paris : Elsevier ; <i>Original Publication</i>: Paris : Editions Scientifiques Elsevier, 1994-, 2023
Medientyp:	academicJournal
ISSN:	1769-664X (electronic)
DOI:	10.1016/j.arcped.2022.11.012
Schlagwort:	Humans Infant, Newborn Female Pregnancy Progesterone Neonatal Screening methods 17-alpha-Hydroxyprogesterone Mothers Adrenal Hyperplasia, Congenital diagnosis Substance Withdrawal Syndrome Opioid-Related Disorders diagnosis
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: English Publication Type: Journal Article Language: English [Arch Pediatr] 2023 Feb; Vol. 30 (2), pp. 77-82. <i>Date of Electronic Publication: </i>2022 Dec 14. MeSH Terms: Adrenal Hyperplasia, Congenital* / diagnosis ; Substance Withdrawal Syndrome* ; Opioid-Related Disorders* / diagnosis ; Humans ; Infant, Newborn ; Female ; Pregnancy ; Progesterone ; Neonatal Screening / methods ; 17-alpha-Hydroxyprogesterone ; Mothers Contributed Indexing: Keywords: 17 OH progesterone; Maternal; Neonatal screening; Opioid addiction Substance Nomenclature: 4G7DS2Q64Y (Progesterone) ; 68-96-2 (17-alpha-Hydroxyprogesterone) Entry Date(s): Date Created: 20221216 Date Completed: 20230207 Latest Revision: 20230207 Update Code: 20231215

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