T <subscript>H</subscript> 17 cell heterogeneity and its role in tissue inflammation.
In: Nature immunology, Jg. 24 (2023), Heft 1, S. 19-29
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Zugriff:
Since their discovery almost two decades ago, interleukin-17-producing CD4 + T cells (T H 17 cells) have been implicated in the pathogenesis of multiple autoimmune and inflammatory disorders. In addition, T H 17 cells have been found to play an important role in tissue homeostasis, especially in the intestinal mucosa. Recently, the use of single-cell technologies, along with fate mapping and various mutant mouse models, has led to substantial progress in the understanding of T H 17 cell heterogeneity in tissues and of T H 17 cell plasticity leading to alternative T cell states and differing functions. In this Review, we discuss the heterogeneity of T H 17 cells and the role of this heterogeneity in diverse functions of T H 17 cells from homeostasis to tissue inflammation. In addition, we discuss T H 17 cell plasticity and its incorporation into the current understanding of T cell subsets and alternative views on the role of T H 17 cells in autoimmune and inflammatory diseases.
(© 2023. Springer Nature America, Inc.)
| Titel: |
T <subscript>H</subscript> 17 cell heterogeneity and its role in tissue inflammation.
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| Autor/in / Beteiligte Person: | Schnell, A ; Littman, DR ; Kuchroo, VK |
| Zeitschrift: | Nature immunology, Jg. 24 (2023), Heft 1, S. 19-29 |
| Veröffentlichung: | New York, NY : Nature America Inc. c2000-, 2023 |
| Medientyp: | academicJournal |
| ISSN: | 1529-2916 (electronic) |
| DOI: | 10.1038/s41590-022-01387-9 |
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