Einzeltreffer — DigiBib

Chemical modifications to nucleic acids occur across the kingdoms of life and carry important regulatory information. Reliable high-resolution mapping of these modifications is the foundation of functional and mechanistic studies, and recent methodological advances based on next-generation sequencing and long-read sequencing platforms are critical to achieving this aim. However, mapping technologies may have limitations that sometimes lead to inconsistent results. Some of these limitations are technical in nature and specific to certain types of technology. Here, however, we focus on common (yet not always widely recognized) pitfalls that are shared among frequently used mapping technologies and discuss strategies to help technology developers and users mitigate their effects. Although the emphasis is primarily on DNA modifications, RNA modifications are also discussed.

Titel:	Navigating the pitfalls of mapping DNA and RNA modifications.
Autor/in / Beteiligte Person:	Kong, Y ; Mead, EA ; Fang, G
Zeitschrift:	Nature reviews. Genetics, Jg. 24 (2023-06-01), Heft 6, S. 363-381
Veröffentlichung:	London, UK : Nature Pub. Group, [2000-, 2023
Medientyp:	academicJournal
ISSN:	1471-0064 (electronic)
DOI:	10.1038/s41576-022-00559-5
Schlagwort:	Sequence Analysis, DNA methods High-Throughput Nucleotide Sequencing methods DNA genetics RNA genetics
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: English Publication Type: Journal Article; Review; Research Support, N.I.H., Extramural Language: English [Nat Rev Genet] 2023 Jun; Vol. 24 (6), pp. 363-381. <i>Date of Electronic Publication: </i>2023 Jan 18. MeSH Terms: DNA* / genetics ; RNA* / genetics ; Sequence Analysis, DNA / methods ; High-Throughput Nucleotide Sequencing / methods References: Nat Commun. 2016 Apr 15;7:11301. (PMID: 27079427) ; Genome Res. 2021 Jul;31(7):1280-1289. (PMID: 34140313) ; Methods Mol Biol. 2021;2198:79-90. (PMID: 32822024) ; Nat Rev Microbiol. 2020 Jan;18(1):7-20. (PMID: 31728064) ; DNA Res. 2013 Dec;20(6):537-47. (PMID: 23804556) ; Chem Commun (Camb). 2018 Feb 11;54(12):1497-1500. (PMID: 29363683) ; Nat Methods. 2015 Aug;12(8):767-72. (PMID: 26121403) ; Nature. 2017 Nov 9;551(7679):251-255. (PMID: 29072297) ; Genome Res. 2013 Jan;23(1):129-41. (PMID: 23093720) ; Nature. 2020 Jul;583(7817):638-643. (PMID: 32555463) ; Nat Chem. 2014 May;6(5):435-40. (PMID: 24755596) ; Sci Adv. 2019 Jul 03;5(7):eaax0250. (PMID: 31281898) ; Trends Biotechnol. 2019 Jan;37(1):72-85. (PMID: 30115375) ; Proc Natl Acad Sci U S A. 2011 Jul 5;108(27):11040-5. (PMID: 21690366) ; Nat Commun. 2021 Jun 8;12(1):3438. (PMID: 34103501) ; Nat Rev Genet. 2011 Nov 15;13(1):7-13. (PMID: 22083101) ; Nat Commun. 2021 Aug 6;12(1):4778. (PMID: 34362929) ; Nat Methods. 2018 Mar;15(3):201-206. (PMID: 29334379) ; Nat Rev Genet. 2018 Jun;19(6):371-384. (PMID: 29643443) ; RNA. 2014 May;20(5):713-20. (PMID: 24664469) ; Nat Struct Mol Biol. 2019 May;26(5):380-388. (PMID: 31061524) ; Nat Rev Genet. 2005 Aug;6(8):597-610. (PMID: 16136652) ; J Biomed Biotechnol. 2009;2009:574398. (PMID: 20011662) ; J Vis Exp. 2009;(23):. (PMID: 19241501) ; Mol Cell. 2011 May 20;42(4):451-64. (PMID: 21514197) ; Anal Chem. 2018 May 1;90(9):5546-5551. (PMID: 29652489) ; Mol Cell. 2015 Feb 19;57(4):750-761. (PMID: 25639471) ; Genome Biol. 2013 Nov 29;14(11):215. (PMID: 24286375) ; Angew Chem Int Ed Engl. 2017 Sep 4;56(37):11268-11271. (PMID: 28371147) ; Nat Microbiol. 2020 Jan;5(1):166-180. (PMID: 31768029) ; Nat Biotechnol. 2018 Jan;36(1):61-69. (PMID: 29227468) ; Genes Dev. 2011 Apr 1;25(7):679-84. (PMID: 21460036) ; Cell. 2019 Jul 25;178(3):731-747.e16. (PMID: 31257032) ; Science. 2022 Feb 4;375(6580):515-522. (PMID: 35113693) ; Protein Cell. 2020 Nov;11(11):792-808. (PMID: 32440736) ; Elife. 2020 Dec 02;9:. (PMID: 33263279) ; Mol Cell. 2019 May 16;74(4):640-650. (PMID: 31100245) ; Sci Rep. 2020 Apr 20;10(1):6590. (PMID: 32313079) ; Nat Commun. 2022 Feb 28;13(1):1072. (PMID: 35228526) ; Cell Host Microbe. 2016 Nov 9;20(5):654-665. (PMID: 27773535) ; Cell. 2013 Apr 25;153(3):692-706. (PMID: 23602152) ; Clin Epigenetics. 2020 Nov 23;12(1):182. (PMID: 33228792) ; Nat Biotechnol. 2019 Apr;37(4):424-429. (PMID: 30804537) ; Nat Genet. 2005 Aug;37(8):853-62. (PMID: 16007088) ; Methods. 2009 Mar;47(3):142-50. (PMID: 18950712) ; Genome Biol. 2022 Apr 28;23(1):108. (PMID: 35484600) ; Mol Plant. 2017 Nov 6;10(11):1387-1399. (PMID: 28965832) ; Nat Chem Biol. 2010 Dec;6(12):863-5. (PMID: 21079590) ; Trends Biochem Sci. 2002 Jul;27(7):344-51. (PMID: 12114023) ; Nat Chem Biol. 2020 Sep;16(9):964-972. (PMID: 32514182) ; Epigenetics. 2014 Jun;9(6):823-8. (PMID: 24717538) ; Bioinformatics. 2019 Nov 1;35(22):4586-4595. (PMID: 30994904) ; Environ Mol Mutagen. 2022 Feb;63(2):98-112. (PMID: 35275417) ; Nucleic Acids Res. 2021 Dec 16;49(22):12757-12768. (PMID: 34850165) ; BMC Genomics. 2019 Feb 4;20(Suppl 1):78. (PMID: 30712508) ; Nat Rev Mol Cell Biol. 2019 Oct;20(10):590-607. (PMID: 31399642) ; RNA Biol. 2017 Sep 2;14(9):1138-1152. (PMID: 27911188) ; Mol Cell. 2018 Jul 19;71(2):306-318.e7. (PMID: 30017583) ; Cell. 2012 Jun 8;149(6):1368-80. (PMID: 22608086) ; Anal Chem. 2017 Jun 6;89(11):6202-6209. (PMID: 28471639) ; Cell Stem Cell. 2017 May 4;20(5):720-731.e5. (PMID: 28343982) ; Nat Rev Genet. 2022 Mar;23(3):169-181. (PMID: 34837041) ; Nat Biotechnol. 2021 Mar;39(3):336-346. (PMID: 33106685) ; Signal Transduct Target Ther. 2021 Jul 9;6(1):254. (PMID: 34238917) ; BMC Biol. 2013 Jan 22;11:4. (PMID: 23339471) ; Signal Transduct Target Ther. 2021 Feb 21;6(1):74. (PMID: 33611339) ; Nucleic Acids Res. 2019 Dec 16;47(22):11771-11789. (PMID: 31722409) ; Genome Biol. 2022 Jan 17;23(1):25. (PMID: 35039061) ; Genes (Basel). 2022 May 19;13(5):. (PMID: 35627295) ; Genome Res. 2017 Sep;27(9):1589-1596. (PMID: 28684555) ; Genome Integr. 2011 Dec 20;2:10. (PMID: 22185597) ; Methods Enzymol. 2015;560:297-329. (PMID: 26253976) ; Nat Rev Genet. 2014 Jul;15(7):469-79. (PMID: 24821474) ; J Biol Chem. 2021 Aug;297(2):100973. (PMID: 34280435) ; Nat Chem Biol. 2020 Jun;16(6):630-634. (PMID: 32203414) ; Genome Biol. 2020 Feb 7;21(1):30. (PMID: 32033565) ; Epigenetics Chromatin. 2021 Jun 19;14(1):28. (PMID: 34147133) ; PLoS Genet. 2013 Jun;9(6):e1003602. (PMID: 23825970) ; RNA. 2018 Nov;24(11):1437-1442. (PMID: 30131401) ; Nat Commun. 2015 Jun 15;6:7438. (PMID: 26074426) ; Nat Methods. 2017 Apr;14(4):411-413. (PMID: 28218897) ; Nat Commun. 2019 Jun 4;10(1):2449. (PMID: 31164644) ; Nucleic Acids Res. 2017 Nov 16;45(20):11594-11606. (PMID: 29036602) ; Nat Rev Genet. 2019 Mar;20(3):157-172. (PMID: 30546107) ; Cell. 2015 May 7;161(4):879-892. (PMID: 25936837) ; Nat Commun. 2020 Nov 26;11(1):6016. (PMID: 33243990) ; Nucleic Acids Res. 2022 Jan 7;50(D1):D196-D203. (PMID: 34986603) ; Nat Rev Genet. 2014 Oct;15(10):647-61. (PMID: 25159599) ; Nucleic Acids Res. 2009 Feb;37(2):e12. (PMID: 19059995) ; Dev Cell. 2018 May 7;45(3):406-416.e3. (PMID: 29656930) ; Nat Methods. 2021 Oct;18(10):1213-1222. (PMID: 34594034) ; Nat Chem Biol. 2016 May;12(5):311-6. (PMID: 26863410) ; Nat Rev Mol Cell Biol. 2019 Oct;20(10):608-624. (PMID: 31520073) ; Cell. 2019 Jun 13;177(7):1781-1796.e25. (PMID: 31104845) ; Nat Chem Biol. 2015 Aug;11(8):592-7. (PMID: 26075521) ; Nat Commun. 2023 Jul 8;14(1):4054. (PMID: 37422489) ; Nat Biotechnol. 2018 Oct 08;:. (PMID: 30295673) ; Epigenetics Chromatin. 2017 Apr 20;10:16. (PMID: 28428825) ; Signal Transduct Target Ther. 2022 Apr 28;7(1):142. (PMID: 35484099) ; Nat Commun. 2021 Dec 10;12(1):7198. (PMID: 34893601) ; J Am Chem Soc. 2014 Nov 26;136(47):16582-7. (PMID: 25347819) ; Anal Chem. 2018 Jun 5;90(11):6859-6866. (PMID: 29792685) ; Nat Commun. 2019 Feb 4;10(1):579. (PMID: 30718479) ; Nat Rev Mol Cell Biol. 2019 Oct;20(10):573-589. (PMID: 31270442) ; Nat Chem Biol. 2018 Feb 14;14(3):226-235. (PMID: 29443970) ; Nucleic Acids Res. 2012 Aug;40(15):7563-72. (PMID: 22610857) ; Genome Res. 2019 Aug;29(8):1329-1342. (PMID: 31201211) ; Nat Biotechnol. 2021 Nov;39(11):1394-1402. (PMID: 34282325) ; Nat Biotechnol. 2023 Oct;41(10):1457-1464. (PMID: 36747096) ; Nat Methods. 2022 Jun;19(6):711-723. (PMID: 35396487) ; Curr Opin Struct Biol. 2010 Jun;20(3):295-304. (PMID: 20447823) ; Nat Rev Genet. 2016 Jun;17(6):365-72. (PMID: 27140282) ; J Nanobiotechnology. 2013 Apr 03;11:8. (PMID: 23552456) ; Genome Biol. 2018 Mar 15;19(1):33. (PMID: 29544553) ; Chem Rev. 2013 Apr 10;113(4):2395-436. (PMID: 23441727) ; BMC Genomics. 2022 Feb 8;23(1):105. (PMID: 35135476) ; Science. 2016 Jan 15;351(6270):282-5. (PMID: 26816380) ; Epigenetics Chromatin. 2020 Oct 7;13(1):42. (PMID: 33028374) ; Nat Commun. 2019 Nov 12;10(1):5126. (PMID: 31719534) ; Curr Opin Struct Biol. 2019 Apr;55:138-146. (PMID: 31102979) ; Nat Plants. 2018 Aug;4(8):554-563. (PMID: 30061746) ; Nat Rev Genet. 2019 Nov;20(11):631-656. (PMID: 31341269) ; Proc Natl Acad Sci U S A. 2014 Dec 2;111(48):E5149-58. (PMID: 25406324) ; Methods Mol Biol. 2017;1562:107-121. (PMID: 28349457) ; Nat Protoc. 2006;1(6):2774-83. (PMID: 17406534) ; Cell. 2013 Apr 25;153(3):678-91. (PMID: 23602153) ; Genome Res. 2021 Feb;31(2):291-300. (PMID: 33468551) ; Methods Mol Biol. 2019;1870:263-271. (PMID: 30539562) ; Front Cell Dev Biol. 2021 Mar 16;9:628415. (PMID: 33816473) ; Nat Biotechnol. 2021 Nov;39(11):1348-1365. (PMID: 34750572) ; Nature. 2017 Jan 19;541(7637):371-375. (PMID: 28002401) ; Science. 2012 May 18;336(6083):934-7. (PMID: 22539555) ; PLoS One. 2018 Feb 8;13(2):e0192722. (PMID: 29420656) ; Nucleic Acids Res. 2019 Nov 4;47(19):10072-10085. (PMID: 31665742) ; Methods Mol Biol. 2019;1870:1-21. (PMID: 30539543) ; Chem Sci. 2017 Jan 1;8(1):200-205. (PMID: 28451166) ; Genome Biol. 2021 Jan 7;22(1):22. (PMID: 33413586) ; Nat Biotechnol. 2012 Dec;30(12):1232-9. (PMID: 23138224) ; Proc Natl Acad Sci U S A. 2021 Feb 2;118(5):. (PMID: 33495335) ; Nucleic Acids Res. 2015 Dec 2;43(21):e148. (PMID: 26184871) ; Genome Biol. 2012 Oct 31;13(10):175. (PMID: 23113984) ; Genome Biol. 2018 Nov 19;19(1):200. (PMID: 30454035) ; Nat Rev Genet. 2014 Nov;15(11):709-21. (PMID: 25223782) ; Cell Res. 2021 Jan;31(1):94-97. (PMID: 32355286) ; Elife. 2020 Jan 14;9:. (PMID: 31931956) ; Mol Cell Biol. 2013 Jul;33(14):2683-90. (PMID: 23671186) ; Nat Protoc. 2021 Apr;16(4):2286-2307. (PMID: 33772246) ; Nat Rev Cancer. 2020 Jun;20(6):303-322. (PMID: 32300195) ; Cell Rep. 2013 Feb 21;3(2):567-76. (PMID: 23352666) ; J Vis Exp. 2017 May 17;(123):. (PMID: 28570531) ; Genome Res. 2018 Dec;28(12):1767-1778. (PMID: 30401733) ; PLoS One. 2015 Nov 25;10(11):e0143756. (PMID: 26606401) ; Nat Methods. 2012 Jan 30;9(2):145-51. (PMID: 22290186) ; Nat Chem Biol. 2018 Feb 14;14(3):215-225. (PMID: 29443978) ; Nat Rev Genet. 2021 Feb;22(2):119-131. (PMID: 33188361) ; Front Genet. 2017 Jul 19;8:100. (PMID: 28769976) ; RNA. 2020 Jan;26(1):19-28. (PMID: 31624092) ; Nat Genet. 2017 Jun;49(6):964-968. (PMID: 28481340) ; Genome Biol. 2021 Oct 18;22(1):295. (PMID: 34663425) ; Environ Mol Mutagen. 2019 Oct;60(8):668-682. (PMID: 31335990) ; Nat Methods. 2018 Jul;15(7):499-504. (PMID: 29941872) ; Science. 2018 Sep 28;361(6409):1346-1349. (PMID: 30262497) ; Nat Rev Genet. 2011 Feb;12(2):87-98. (PMID: 21191423) ; FEBS Lett. 2018 Jun;592(12):2032-2047. (PMID: 29683490) ; Nat Biotechnol. 2012 Nov;30(11):1107-16. (PMID: 23138310) ; Nature. 2012 Apr 29;485(7397):201-6. (PMID: 22575960) ; Cell Res. 2011 Dec;21(12):1670-6. (PMID: 22124233) ; Methods. 2016 Sep 1;107:63-72. (PMID: 26968262) ; BMC Genomics. 2017 Jun 5;18(1):442. (PMID: 28583074) ; Methods. 2010 Nov;52(3):218-22. (PMID: 20434563) ; Science. 2018 Sep 28;361(6409):1336-1340. (PMID: 30262495) ; Nat Rev Genet. 2011 Aug 18;12(9):641-55. (PMID: 21850044) ; Nature. 2014 Nov 6;515(7525):143-6. (PMID: 25192136) ; Nucleic Acids Res. 2014 Jul;42(13):8745-54. (PMID: 24966351) ; Sci Adv. 2020 Mar 18;6(12):eaay3335. (PMID: 32206710) ; Nucleic Acids Res. 2011 Jul;39(12):5015-24. (PMID: 21378125) ; Nat Methods. 2011 Nov 20;9(1):75-7. (PMID: 22101853) ; Nat Commun. 2021 Oct 13;12(1):5976. (PMID: 34645826) ; Science. 2020 Jun 26;368(6498):1449-1454. (PMID: 32587015) ; Sci Rep. 2018 Apr 11;8(1):5801. (PMID: 29643477) ; Cell. 2012 Jun 22;149(7):1635-46. (PMID: 22608085) ; Nat Rev Genet. 2017 May;18(5):275-291. (PMID: 28216634) ; Mol Cell. 2020 May 7;78(3):382-395.e8. (PMID: 32183942) ; Genome Biol. 2020 Mar 3;21(1):54. (PMID: 32127008) ; Comput Struct Biotechnol J. 2020 Jan 07;18:207-219. (PMID: 31993111) ; Nucleic Acids Res. 2021 Jan 25;49(2):e7. (PMID: 32710622) ; Nature. 2016 Apr 21;532(7599):329-33. (PMID: 27027282) ; Cell Rep. 2014 Jun 12;7(5):1353-1361. (PMID: 24882006) ; BMC Biol. 2014 May 30;12:42. (PMID: 24885439) ; Nat Biotechnol. 2016 May 6;34(5):518-24. (PMID: 27153285) ; Nat Rev Genet. 2022 Jul;23(7):411-428. (PMID: 35256817) ; Cell Mol Life Sci. 2021 Nov;78(21-22):6745-6762. (PMID: 34463773) ; J Hum Genet. 2020 Jan;65(1):25-33. (PMID: 31602005) ; Nat Commun. 2019 Dec 11;10(1):5669. (PMID: 31827101) ; Genome Res. 2018 Jul;28(7):1067-1078. (PMID: 29764913) ; Nat Commun. 2019 Sep 9;10(1):4079. (PMID: 31501426) ; Genes (Basel). 2017 May 23;8(6):. (PMID: 28545252) ; Nat Struct Mol Biol. 2016 Jan;23(1):24-30. (PMID: 26689968) ; Proc Natl Acad Sci U S A. 2013 Nov 19;110(47):18904-9. (PMID: 24167255) ; Nat Commun. 2016 Oct 07;7:13052. (PMID: 27713410) ; Nat Methods. 2021 May;18(5):491-498. (PMID: 33820988) ; Cell Genom. 2022 Feb 9;2(2):. (PMID: 35252946) ; Cell. 2015 May 7;161(4):868-78. (PMID: 25936839) ; Front Genet. 2017 Nov 01;8:166. (PMID: 29163634) ; Cell. 2015 May 7;161(4):893-906. (PMID: 25936838) ; Nat Methods. 2010 Jun;7(6):461-5. (PMID: 20453866) ; J Biol Chem. 1978 Feb 10;253(3):927-34. (PMID: 621212) ; Nat Rev Genet. 2014 Feb;15(2):121-32. (PMID: 24434847) ; Nat Methods. 2017 Apr;14(4):407-410. (PMID: 28218898) ; Nat Commun. 2023 Jan 19;14(1):334. (PMID: 36658122) ; Nature. 2016 Feb 25;530(7591):441-6. (PMID: 26863196) ; Nat Rev Genet. 2008 Jun;9(6):465-76. (PMID: 18463664) ; Front Genet. 2015 Jan 26;6:2. (PMID: 25674102) ; Environ Mol Mutagen. 2017 Jun;58(5):235-263. (PMID: 28485537) ; Nucleic Acids Res. 2020 May 21;48(9):4940-4945. (PMID: 32255181) ; Genome Res. 2019 Oct;29(10):1622-1634. (PMID: 31537639) ; Trends Genet. 2022 May;38(5):454-467. (PMID: 34991904) ; Front Immunol. 2019 Feb 12;10:210. (PMID: 30809228) ; Nat Methods. 2020 Mar;17(3):319-327. (PMID: 32042188) ; Nat Rev Genet. 2017 Sep;18(9):517-534. (PMID: 28555658) ; Mol Cell. 2018 Sep 20;71(6):973-985.e5. (PMID: 30197295) ; Genome Biol. 2021 Dec 6;22(1):332. (PMID: 34872606) ; Nat Protoc. 2016 Jul;11(7):1191-205. (PMID: 27281647) ; Trends Biochem Sci. 2015 Apr;40(4):221-32. (PMID: 25797096) ; Int J Mol Sci. 2021 Apr 27;22(9):. (PMID: 33925624) ; Cell. 2017 Jun 15;169(7):1187-1200. (PMID: 28622506) ; Nature. 2011 May 19;473(7347):398-402. (PMID: 21460836) ; Cell. 2018 Nov 15;175(5):1228-1243.e20. (PMID: 30392959) ; Proc Natl Acad Sci U S A. 2000 May 9;97(10):5237-42. (PMID: 10805783) ; Curr Protoc Mol Biol. 2010 Jul;Chapter 7:Unit 7.9.1-17. (PMID: 20583099) ; BMC Genomics. 2019 Jun 3;20(1):445. (PMID: 31159718) ; Annu Rev Biochem. 2014;83:585-614. (PMID: 24905787) ; PLoS One. 2010 Jan 26;5(1):e8888. (PMID: 20126651) ; Free Radic Biol Med. 2021 Dec;177:337-346. (PMID: 34715295) ; Mol Cell. 2016 May 5;62(3):335-345. (PMID: 27117702) ; Nat Rev Mol Cell Biol. 2021 Jun;22(6):375-392. (PMID: 33658722) ; Nat Biotechnol. 2021 Oct;39(10):1278-1291. (PMID: 33986546) ; PLoS Genet. 2016 Feb 12;12(2):e1005854. (PMID: 26870957) ; Proc Natl Acad Sci U S A. 2018 Jan 30;115(5):E1069-E1074. (PMID: 29339507) ; Front Genet. 2021 Jan 27;11:610386. (PMID: 33584810) ; Nucleic Acids Res. 2015 Jan;43(Database issue):D298-9. (PMID: 25378308) ; Science. 2009 Jan 2;323(5910):133-8. (PMID: 19023044) ; Cell. 2018 Dec 13;175(7):1872-1886.e24. (PMID: 30449621) ; Bio Protoc. 2017 Jan 05;7(1):e2095. (PMID: 34458425) ; FEBS J. 2008 Apr;275(8):1608-16. (PMID: 18331348) ; Nucleic Acids Res. 2014 May;42(9):5929-36. (PMID: 24634440) Grant Information: R01 HG011095 United States HG NHGRI NIH HHS; R35 GM139655 United States GM NIGMS NIH HHS; UL1 TR004419 United States TR NCATS NIH HHS Substance Nomenclature: 9007-49-2 (DNA) ; 63231-63-0 (RNA) Entry Date(s): Date Created: 20230118 Date Completed: 20230522 Latest Revision: 20240323 Update Code: 20240323 PubMed Central ID: PMC10722219

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Navigating the pitfalls of mapping DNA and RNA modifications.