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While Alzheimer's disease (AD) is associated with inner retina thinning (retinal nerve fiber layer and ganglion cell layer), we have observed photoreceptor outer nuclear layer (ONL) thinning in patients with frontotemporal lobar degeneration tauopathy (FTLD-Tau) compared to normal controls. We hypothesized that ONL thinning may distinguish FTLD-Tau from patients with biomarker evidence of AD neuropathologic change (ADNC) and will correlate with FTLD-Tau disease severity. Predicted FTLD-Tau (pFTLD-Tau; n = 21; 33 eyes) and predicted ADNC (pADNC; n = 24; 46 eyes) patients were consecutively enrolled, underwent optical coherence tomography macula imaging, and disease was categorized (pFTLD-Tau vs. pADNC) with cerebrospinal fluid biomarkers, genetic testing, and autopsy data when available. Adjusting for age, sex, and race, pFTLD-Tau patients had a thinner ONL compared to pADNC, while retinal nerve fiber layer and ganglion cell layer were not significantly different. Reduced ONL thickness correlated with worse performance on Folstein Mini-Mental State Examination and clinical dementia rating plus frontotemporal dementia sum of boxes for pFTLD-Tau but not pADNC. Photoreceptor ONL thickness may serve as an important noninvasive diagnostic marker that distinguishes FTLD-Tau from AD neuropathologic change.

Titel:	Retinal photoreceptor layer thickness has disease specificity and distinguishes predicted FTLD-Tau from biomarker-determined Alzheimer's disease.
Autor/in / Beteiligte Person:	Kim, BJ ; Grossman, M ; Aleman, TS ; Song, D ; Cousins, KAQ ; McMillan, CT ; Saludades, A ; Yu, Y ; Lee, EB ; Wolk, D ; Van Deerlin, VM ; Shaw, LM ; Ying, GS ; Irwin, DJ
Zeitschrift:	Neurobiology of aging, Jg. 125 (2023-05-01), S. 74-82
Veröffentlichung:	New York : Elsevier ; <i>Original Publication</i>: Fayetteville, N.Y. : Ankho International., 2023
Medientyp:	academicJournal
ISSN:	1558-1497 (electronic)
DOI:	10.1016/j.neurobiolaging.2023.01.015
Schlagwort:	Humans Biomarkers cerebrospinal fluid Photoreceptor Cells, Vertebrate pathology tau Proteins cerebrospinal fluid Alzheimer Disease diagnostic imaging Alzheimer Disease cerebrospinal fluid Frontotemporal Dementia Frontotemporal Lobar Degeneration diagnostic imaging Tauopathies diagnosis
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: English Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Language: English [Neurobiol Aging] 2023 May; Vol. 125, pp. 74-82. <i>Date of Electronic Publication: </i>2023 Feb 01. MeSH Terms: Alzheimer Disease* / diagnostic imaging ; Alzheimer Disease* / cerebrospinal fluid ; Frontotemporal Dementia* ; Frontotemporal Lobar Degeneration* / diagnostic imaging ; Tauopathies* / diagnosis ; Humans ; Biomarkers / cerebrospinal fluid ; Photoreceptor Cells, Vertebrate / pathology ; tau Proteins / cerebrospinal fluid References: Alzheimers Dement (N Y). 2019 Oct 09;5:570-578. (PMID: 31650013) ; Acta Ophthalmol. 2016 Sep;94(6):e454-9. (PMID: 26895692) ; J Neuropathol Exp Neurol. 2011 Jan;70(1):63-8. (PMID: 21157377) ; Neurology. 2011 Mar 15;76(11):1006-14. (PMID: 21325651) ; Neurol Clin Pract. 2021 Aug;11(4):e516-e523. (PMID: 34484950) ; Alzheimers Dement (Amst). 2019 Sep 25;11:659-669. (PMID: 31667327) ; JAMA Neurol. 2013 Nov;70(11):1411-7. (PMID: 24081456) ; J Biophotonics. 2020 May;13(5):e201960187. (PMID: 32057191) ; Acta Neuropathol Commun. 2021 Nov 18;9(1):184. (PMID: 34794500) ; Mov Disord. 2017 Jun;32(6):853-864. (PMID: 28467028) ; Ophthalmology. 2019 Apr;126(4):497-510. (PMID: 30114417) ; Neurology. 2017 Oct 10;89(15):1604-1611. (PMID: 28887373) ; J Exp Med. 2014 Sep 22;211(10):1937-45. (PMID: 25155018) ; Alzheimers Dement. 2018 Apr;14(4):535-562. (PMID: 29653606) ; PLoS One. 2012;7(4):e34823. (PMID: 22536333) ; Brain. 2007 Jun;130(Pt 6):1552-65. (PMID: 17405767) ; JAMA Neurol. 2018 Jun 1;75(6):738-745. (PMID: 29554190) ; Alzheimers Dement. 2014 Jul;10(4):477-484.e1. (PMID: 23978324) ; JAMA Netw Open. 2022 Mar 01;5(3):e220902. (PMID: 35238934) ; J Neurol Neurosurg Psychiatry. 2021 Sep;92(9):983-994. (PMID: 34108266) ; Alzheimers Dement. 2011 May;7(3):270-9. (PMID: 21514249) ; Alzheimers Dement (Amst). 2021 May 11;13(1):e12181. (PMID: 34013017) ; Alzheimers Res Ther. 2019 Nov 23;11(1):91. (PMID: 31759396) ; Acta Neuropathol. 2015 Apr;129(4):469-91. (PMID: 25549971) ; Neurol Sci. 2022 Aug;43(8):4803-4809. (PMID: 35411501) ; Trans Am Ophthalmol Soc. 2015;113:T12. (PMID: 26877563) ; Br J Ophthalmol. 2022 Mar;106(3):388-395. (PMID: 33243829) ; Invest Ophthalmol Vis Sci. 2018 Jun 1;59(7):2768-2777. (PMID: 29860463) ; IEEE Trans Pattern Anal Mach Intell. 2006 Jan;28(1):119-34. (PMID: 16402624) ; JAMA Neurol. 2020 Jul 1;77(7):829-839. (PMID: 32338734) ; Brain. 2005 Sep;128(Pt 9):1996-2005. (PMID: 16033782) ; Neurology. 2013 Jan 29;80(5):496-503. (PMID: 23359374) ; Exp Eye Res. 2017 Dec;165:105-108. (PMID: 28974357) ; IEEE Trans Med Imaging. 2009 Sep;28(9):1436-47. (PMID: 19278927) ; Ann Neurol. 2021 Jan;89(1):165-176. (PMID: 33098308) ; Brain. 2018 Jul 1;141(7):2181-2193. (PMID: 29878075) ; Ophthalmic Epidemiol. 2022 Apr;29(2):117-127. (PMID: 33977829) ; Alzheimers Dement. 2011 May;7(3):293-9. (PMID: 21575870) ; Ophthalmology. 2011 Dec;118(12):2403-8. (PMID: 21907415) ; Ophthalmic Epidemiol. 2017 Apr;24(2):130-140. (PMID: 28102741) ; Ann Neurol. 2006 Jan;59(1):156-65. (PMID: 16374817) ; Ann Neurol. 2010 Jun;67(6):749-60. (PMID: 20517936) ; Alzheimer Dis Assoc Disord. 2011 Apr-Jun;25(2):159-63. (PMID: 21346518) ; Alzheimers Dement. 2011 Jul;7(4):e84-93. (PMID: 21784346) ; Mov Disord. 2015 Dec;30(14):1944-53. (PMID: 26359930) ; Lancet Neurol. 2012 Feb;11(2):170-8. (PMID: 22265212) ; Acta Neuropathol. 2010 Jan;119(1):1-4. (PMID: 19924424) ; Acta Neuropathol Commun. 2021 Jan 29;9(1):17. (PMID: 33509294) ; Am J Ophthalmol. 2010 Mar;149(3):496-502.e1. (PMID: 20042179) ; Mol Cell Proteomics. 2009 Jun;8(6):1206-18. (PMID: 19279044) ; Acta Neuropathol. 2012 Jan;123(1):1-11. (PMID: 22101365) ; PLoS One. 2020 May 29;15(5):e0232785. (PMID: 32469871) ; Front Neurosci. 2019 Apr 04;13:298. (PMID: 31019447) ; Brain. 2020 Jul 1;143(7):2295-2311. (PMID: 32666090) ; JAMA Ophthalmol. 2021 May 01;139(5):548-556. (PMID: 33764406) ; Brain. 2015 Sep;138(Pt 9):2732-49. (PMID: 26141491) ; Alzheimers Dement. 2011 May;7(3):263-9. (PMID: 21514250) ; Invest Ophthalmol Vis Sci. 1995 Jan;36(1):24-31. (PMID: 7822152) ; Prog Retin Eye Res. 2021 Jul;83:100938. (PMID: 33460813) ; Front Aging Neurosci. 2013 Feb 21;5:6. (PMID: 23440936) ; N Engl J Med. 1986 Aug 21;315(8):485-7. (PMID: 3736630) ; PLoS One. 2012;7(4):e34891. (PMID: 22514688) ; Ophthalmol Retina. 2019 Jun;3(6):489-499. (PMID: 31174670) ; Front Neurosci. 2021 Sep 22;15:731614. (PMID: 34630020) Grant Information: P01 AG017586 United States AG NIA NIH HHS; U01 AG052943 United States AG NIA NIH HHS; P50 NS053488 United States NS NINDS NIH HHS; P01 AG066597 United States AG NIA NIH HHS; P30 EY001583 United States EY NEI NIH HHS; R01 NS109260 United States NS NINDS NIH HHS; P30 AG072979 United States AG NIA NIH HHS Substance Nomenclature: 0 (Biomarkers) ; 0 (tau Proteins) Entry Date(s): Date Created: 20230301 Date Completed: 20230324 Latest Revision: 20240502 Update Code: 20240502 PubMed Central ID: PMC10038934

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Retinal photoreceptor layer thickness has disease specificity and distinguishes predicted FTLD-Tau from biomarker-determined Alzheimer's disease.