Prevalence and factors associated with hypothyroidism in children with sickle cell anemia aged 6 months - 17 years attending the Sickle Cell Clinic, Mulago Hospital, Uganda; a cross-sectional study.

Kaudha, G ; Piloya, T ; et al.

In: BMC endocrine disorders, Jg. 23 (2023-03-13), Heft 1, S. 60

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Purpose: Hypothyroidism has been reported at a prevalence of 6% in children and adolescents with Sickle cell anemia. In this study, we determined the prevalence and factors associated with hypothyroidism among children with Sickle cell anemia attending the Sickle Cell Clinic, in Mulago hospital, Uganda.

Methods: A cross-sectional study was conducted among children aged 6 months - 17 years with a confirmed diagnosis of Sickle Cell Anemia, with no prior diagnosis of hypothyroidism and in steady state attending the Sickle Cell Clinic in Mulago hospital. Data was collected using a structured questionnaire and a blood sample was used to measure thyroid stimulating hormone and free thyroxine.

Results: Of the 332 children enrolled, sixty (18.1%) participants had sub-clinical hypothyroidism (95% CI: 14.3 - 22.6). Factors associated with hypothyroidism included constipation [adjusted odds ratio: 3.1, 95% CI:1.0 - 9.0, p = 0.043] and male sex [adjusted odds ratio:2.0, 95% CI:1.1- 3.5, p = 0.025].

Conclusion: Approximately 1 in 5 children (18.1%) had sub-clinical hypothyroidism. Males and children who presented with constipation were more likely to have sub-clinical hypothyroidism.

Titel:	Prevalence and factors associated with hypothyroidism in children with sickle cell anemia aged 6 months - 17 years attending the Sickle Cell Clinic, Mulago Hospital, Uganda; a cross-sectional study.
Autor/in / Beteiligte Person:	Kaudha, G ; Piloya, T ; Musiime, V ; Kuteesa, MG ; Namugerwa, S ; Owomugisha, G ; Wachepa, SA ; Lubwama, SK ; Kiguli, S ; Tumwine, JK
Link:	Full Text Finder (Volltext)
Zeitschrift:	BMC endocrine disorders, Jg. 23 (2023-03-13), Heft 1, S. 60
Veröffentlichung:	London : BioMed Central, [2001-, 2023
Medientyp:	academicJournal
ISSN:	1472-6823 (electronic)
DOI:	10.1186/s12902-023-01317-2
Schlagwort:	Adolescent Child Humans Male Cross-Sectional Studies Uganda epidemiology Prevalence Hospitals Anemia, Sickle Cell complications Anemia, Sickle Cell epidemiology Hypothyroidism complications
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: English Publication Type: Journal Article Language: English [BMC Endocr Disord] 2023 Mar 13; Vol. 23 (1), pp. 60. <i>Date of Electronic Publication: </i>2023 Mar 13. MeSH Terms: Anemia, Sickle Cell* / complications ; Anemia, Sickle Cell* / epidemiology ; Hypothyroidism* / complications ; Adolescent ; Child ; Humans ; Male ; Cross-Sectional Studies ; Uganda / epidemiology ; Prevalence ; Hospitals References: Ital J Pediatr. 2012 Sep 17;38:44. (PMID: 22985522) ; Iran J Med Sci. 2014 Jan;39(1):60-3. (PMID: 24453395) ; Br J Haematol. 2006 Nov;135(4):574-82. (PMID: 17054676) ; J Trop Pediatr. 1992 Dec;38(6):307-13. (PMID: 1844090) ; Am J Prev Med. 2011 Dec;41(6 Suppl 4):S398-405. (PMID: 22099364) ; Acta Biomed. 2017 Apr 28;88(1):119-127. (PMID: 28467346) ; Endocr Metab Immune Disord Drug Targets. 2019;19(1):46-52. (PMID: 30207251) ; Acta Paediatr Jpn. 1996 Oct;38(5):460-3. (PMID: 8942004) ; Lancet Glob Health. 2016 Mar;4(3):e195-200. (PMID: 26833239) ; Lancet. 2010 Dec 11;376(9757):2018-31. (PMID: 21131035) ; Clin Lab Haematol. 1989;11(4):309-15. (PMID: 2514063) ; Expert Rev Hematol. 2019 Aug;12(8):589-596. (PMID: 31206301) ; Am J Med. 1992 May;92(5):567-70. (PMID: 1580305) ; J Blood Med. 2016 Dec 13;7:283-289. (PMID: 28008293) ; Lancet. 2013 Jan 12;381(9861):142-51. (PMID: 23103089) ; Turk J Haematol. 2013 Mar;30(1):25-31. (PMID: 24385749) ; Endocr Rev. 2008 Feb;29(1):76-131. (PMID: 17991805) ; Ital J Pediatr. 2018 Feb 17;44(1):25. (PMID: 29454373) ; J Family Community Med. 2003 Jan;10(1):55-8. (PMID: 23011981) Grant Information: R25 TW011213 United States TW FIC NIH HHS Contributed Indexing: Keywords: Constipation; Hypothyroidism; Sickle cell anemia; Uganda Entry Date(s): Date Created: 20230313 Date Completed: 20230314 Latest Revision: 20230511 Update Code: 20240513 PubMed Central ID: PMC10008711

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